Adult restoration of Shank3 expression rescues selective autistic-like phenotypes by Mei, Yuan, Monteiro, Patricia, Zhou, Yang, Kim, Jinah, Gao, Xian, Fu, Zhanyan, Feng, Guoping

“…Disruptions of the Shank3 gene in mouse models have resulted in synaptic defects and autistic-like behaviours including anxiety, social interaction deficits, and repetitive behaviour. …”
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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction by Peca, Joao, Feliciano, Catia, Ting, Jonathan T., Wang, Wenting, Wells, Michael F., Venkatraman, Talaignair N., Lascola, Christopher D., Fu, Zhanyan, Feng, Guoping

“…Our findings demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice.…”
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Autistic Adults Show Intact Learning on a Visuospatial Serial Reaction Time Task by Treves, Isaac N., Cannon, Jonathan, Shin, Eren, Li, Cindy E., Bungert, Lindsay, O’Brien, Amanda, Cardinaux, Annie, Sinha, Pawan, Gabrieli, John D. E.

“…Abstract Some theories have proposed that autistic individuals have difficulty learning predictive relationships. …”
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Youth and Caregivers’ Perspective on Teens Engaged as Mentors (TEAM): An Inclusive Peer Mentoring Program for Autistic Adolescents by O’Hagan, Belinda, Sonikar, Pooja, Grace, River, Castillo, Dasha, Chen, Emily, Agrawal, Malhaar, Dufresne, Simone, Rossetti, Zach, Bartolotti, Lauren, Krauss, Shari

“…Stakeholder focus groups were conducted annually from 2016 to 2020 with 16 autistic mentees (ages 9–13), 30 autistic and neurotypical mentors (ages 14–21), and 30 caregivers. …”
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Exclusion of females in autism research: Empirical evidence for a “leaky” recruitment‐to‐research pipeline by D'Mello, Anila M, Frosch, Isabelle R, Li, Cindy E, Cardinaux, Annie L, Gabrieli, John DE

“…Using the ADOS as a confirmatory diagnostic measure resulted in the exclusion of autistic females at a rate over 2.5 times higher than that of autistic males. …”
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Autonomic and Electrophysiological Evidence for Reduced Auditory Habituation in Autism by Gandhi, Tapan K., Tsourides, Kleovoulos, Singhal, Nidhi, Cardinaux, Annie, Jamal, Wasifa, Pantazis, Dimitrios, Kjelgaard, Margaret, Sinha, Pawan

“…Results thus far have indicated that autistic individuals do not differ systematically from controls in sensory acuity/sensitivity. …”
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Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures by Jamal, Wasifa, Cardinaux, Annie, Haskins, Amanda J., Kjelgaard, Margaret, Sinha, Pawan

“…We collected electroencephalography data from 22 neuro-typical(NT) and 13 autistic(ASD) children during the presentation of visual and auditory sequences of repeated stimuli. …”
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Rhythmic and interval‐based temporal orienting in autism by Cannon, Jonathan, Eldracher, Emelie, Cardinaux, Annie, Irfan, Fatima, Bungert, Lindsay, Li, Cindy, O'Brien, Amanda, Treves, Isaac, Diamond, Sidney, Sinha, Pawan

“…We explored the overlap of audition, attention, and prediction with an online auditory "temporal orienting" task in which participants utilized predictive timing cues (both rhythmic and interval-based) to improve their detection of faint sounds. We compared an autistic (n = 78) with a nonautistic (n = 83) group, controlling for nonverbal IQ, and used signal detection measures and reaction times to evaluate the effect of valid temporally predictive cues. …”
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STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study by Erickson, Craig A., Veenstra-Vanderweele, Jeremy M., Melmed, Raun D., McCracken, James T., Ginsberg, Lawrence D., Sikich, Linmarie, Scahill, Lawrence, Cherubini, Maryann, Zarevics, Peter, Walton-Bowen, Karen, Carpenter, Randall L., Wang, Paul P., King, Bryan H., Bear, Mark

“…We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32 children and adolescents with either Autistic Disorder or Pervasive Developmental Disorder—Not Otherwise Specified, and a score ≥17 on the Aberrant Behavior Checklist (ABC)—Irritability subscale. …”
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Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex by Zhao, Jian-Ping, Yoshii, Akira

“…Tuberous sclerosis complex (TSC) is a neurogenetic disorder associated with epilepsy, intellectual disabilities, and autistic behaviors. These neurological symptoms result from synaptic dysregulations, which shift a balance between excitation and inhibition. …”
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Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior by Wohr, Markus, Roullet, Florence I., Hung, Albert Y., Sheng, Morgan Hwa-Tze, Crawley, Jacqueline N.

“…Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. …”
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Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity by Wiemer, Erik A.C., Ip, Pak Kan, Nagakura, Ikue, Petravicz, Jeremy C., Li, Keji, Sur, Mriganka

“…Although this region contains exons of 29 genes, disrupting only a small segment of the region, which spans five genes, is sufficient to cause autistic traits. One candidate gene in this critical segment is MVP, which encodes for the major vault protein (MVP) that has been implicated in regulation of cellular transport mechanisms. …”
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