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Teacher Guided Architecture Search
Published 2021“…Most prior work has used the performance of candidate models following limited training to automatically guide the search in a feasible way. Could further gains in computational efficiency be achieved by guiding the search via measurements of a high performing network with unknown detailed architecture (e.g. the primate visual system)? …”
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Softstar: Heuristic-guided probabilistic inference
Published 2017“…We propose the Softstar algorithm, a softened heuristic-guided search technique for the maximum entropy inverse optimal control model of sequential behavior. …”
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Dynamic control of visually guided locomotion through corticosubthalamic projections
Published 2023“…Our behavioral modeling, calcium imaging, and optogenetics manipulation results suggest that the M2-STN pathway can be recruited during visually guided locomotion to rapidly and precisely control the pedunculopontine nucleus (PPN) of the mesencephalic locomotor region through the basal ganglia. …”
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions
Published 2016“…We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memory-guided visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). …”
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Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies
Published 2023“…Genetically encoded potassium indicators lack optimal binding affinity for monitoring intracellular dynamics in mammalian cells. Through structure-guided design and genome mining of potassium binding proteins, we developed green fluorescent potassium indicators with a broad range of binding affinities. …”
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Structure and engineering of the minimal type VI CRISPR-Cas13bt3
Published 2023“…Here, we report the structures of the Cas13bt3-guide RNA complex and the Cas13bt3-guide RNA-target RNA complex. …”
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Intuitive Theories as Grammars for Causal Inference
Published 2021“…The resulting framework highlights an analogy between causal theories and linguistic grammars: just as grammars generate sentences and guide inferences about their interpretation, causal theories specify a generative process for events, and guide causal inference.…”
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A Model of Tacit Knowledge and Action
Published 2010“…However, tacit knowledge is an accepted guide of behavior, especially in unfamiliar contexts. …”
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Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
Published 2023“…<jats:title>Abstract</jats:title><jats:p>Transposon-encoded IscB family proteins are RNA-guided nucleases in the OMEGA (obligate mobile element-guided activity) system, and likely ancestors of the RNA-guided nuclease Cas9 in the type II CRISPR-Cas adaptive immune system. …”
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A tutorial introduction to Bayesian models of cognitive development
Published 2015“…Our goal is to provide an intuitive and accessible guide to the what, the how, and the why of the Bayesian approach: what sorts of problems and data the framework is most relevant for, and how and why it may be useful for developmentalists. …”
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The role of prefrontal cortex in the control of feature attention in area V4
Published 2021“…When searching for an object in a cluttered scene, we can use our memory of the target object features to guide our search, and the responses of neurons in multiple cortical visual areas are enhanced when their receptive field contains a stimulus sharing target object features. …”
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Foundations of intuitive power analyses in children and adults
Published 2023“…These findings indicate that both young children and adults metacognitively represent their own ability to make discriminations even in the absence of data, and can use this to guide efficient and effective exploration.…”
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Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)
Published 2016“…This protocol provides a step-by-step guide to implement the TRAP methodology, which takes 2 d to complete once all materials are in hand.…”
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Frequency-specific hippocampal-prefrontal interactions during associative learning
Published 2016“…Rapid object associative learning may occur in PFC, whereas HPC may guide neocortical plasticity by signaling success or failure via oscillatory synchrony in different frequency bands.…”
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Efficient genome editing in plants using a CRISPR/Cas system
Published 2016“…The non-coding RNAs form a functional complex with CRISPR-associated (Cas) proteins and guide the complex to cleave complementary invading DNA. …”
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