DNA Damage and Its Links to Neurodegeneration by Madabhushi, Ram, Pan, Ling, Tsai, Li-Huei

Get full text
Get full text
Get full text

Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration by Kim, Dohoon, Tsai, Li-Huei

Get full text
Get full text

Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration by Victor, Matheus B, Tsai, Li-Huei

Get full text

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration by Graeff, Johannes, Kahn, Martin, Samiei, Alireza, Gao, Jun, Ota, Kristie, Rei, Damien, Tsai, Li-Huei

“…We found that in this model, CR significantly delayed the onset of neurodegeneration and synaptic loss and dysfunction, and thereby preserved cognitive capacities. …”
Get full text
Get full text
Get full text

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy by Wu, Tiffany, Dejanovic, Borislav, Gandham, Vineela D., Gogineni, Alvin, Edmonds, Rose, Schauer, Stephen, Srinivasan, Karpagam, Huntley, Melanie A., Wang, Yuanyuan, Wang, Tzu-Ming, Hedehus, Maj, Barck, Kai H., Stark, Maya, Ngu, Hai, Foreman, Oded, Meilandt, William J., Elstrott, Justin, Chang, Michael C., Hansen, David V., Carano, Richard A.D., Sheng, Morgan, Hanson, Jesse E.

“…These results demonstrate that complement activation contributes to neurodegeneration caused by tau pathology and suggest that blocking C3 function might be protective in AD and other tauopathies.…”
Get full text

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration by Zhou, Jiechao, Wade, Sarah D, Graykowski, David, Xiao, Mei-Fang, Zhao, Binhui, Giannini, Lucia AA, Hanson, Jesse E, van Swieten, John C, Sheng, Morgan, Worley, Paul F, Dejanovic, Borislav

“…Together, these results show that Nptx2 regulates complement activity and microglial synapse elimination in the brain and that diminished Nptx2 concentrations might exacerbate complement-mediated neurodegeneration in patients with FTD.</jats:p>…”
Get full text

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration by Welch, Gwyneth M, Boix, Carles A, Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B, Dileep, Vishnu, Bozzelli, P Lorenzo, Su, Qiao, Cheng, Jemmie D, Lee, Audrey, Leary, Noelle S, Pfenning, Andreas R, Kellis, Manolis, Tsai, Li-Huei

“…<jats:p>DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation associated with neurodegeneration. …”
Get full text

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons by Dobbin, Matthew M., Madabhushi, Ram, Pan, Ling, Chen, Yue, Kim, Dohoon, Gao, Jun, Ahanonu, Biafra, Pao, Ping-Chieh, Qiu, Yi, Zhao, Yingming, Tsai, Li-Huei

“…HDAC1 mutations that mimic a constitutively acetylated state rendered neurons more susceptible to DNA damage, whereas pharmacological SIRT1 activators that promoted HDAC1 deacetylation also reduced DNA damage in two mouse models of neurodegeneration. We propose that SIRT1 is an apical transducer of the DSB response and that SIRT1 activation offers an important therapeutic avenue in neurodegeneration.…”
Get full text
Get full text
Get full text
Get full text

TREM2‐dependent microglial function is essential for remyelination and subsequent neuroprotection by Wang, Yuanyuan, Kyauk, Roxanne V, Shen, Yun‐An A, Xie, Luke, Reichelt, Mike, Lin, Han, Jiang, Zhiyu, Ngu, Hai, Shen, Kimberle, Greene, Jacob J, Sheng, Morgan, Yuen, Tracy J

“…Disability in multiple sclerosis (MS) is driven in part by the failure of remyelination and progressive neurodegeneration. Microglia, and specifically triggering receptor expressed on myeloid cells 2 (TREM2), a factor highly expressed in microglia, have been shown to play an important role in remyelination. …”
Get full text

Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models by Shim, Hong Seok, Horner, James W, Wu, Chang-Jiun, Li, Jiexi, Lan, Zheng D, Jiang, Shan, Xu, Xueping, Hsu, Wen-Hao, Zal, Tomasz, Flores, Ivonne I, Deng, Pingna, Lin, Yuan-Ta, Tsai, Li-Huei, Wang, Y Alan, DePinho, Ronald A

“…Amyloid-induced neurodegeneration plays a central role in Alzheimer's disease (AD) pathogenesis. …”
Get full text

Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes by Wertz, Mary H., Pineda, S. Sebastian, Lee, Hyeseung, Kulicke, Ruth, Kellis, Manolis, Heiman, Myriam

Get full text

Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease by Pinals, Rebecca L, Tsai, Li-Huei

“…Such models have delivered crucial insights into cellular mechanisms and cell type–specific roles underlying the perturbed biological functions that trigger pathogenic cascades and propagate neurodegeneration. Collectively, hiPSC-based models are envisioned to be an impactful platform for uncovering fundamental AD understanding, with high translational value toward AD drug discovery and testing.…”
Get full text

Monoacylglycerol lipase contributes to pathogenesis of Alzheimer's disease by Chen, Rongqing, Zhang, Jian, Wu, Yan, Wang, Dongqing, Feng, Guoping, Tang, Ya-Ping, Chen, Chu

“…MAGL inhibition also prevented neuroinflammation, decreased neurodegeneration, maintained integrity of hippocampal synaptic structure and function, and improved long-term synaptic plasticity, spatial learning and memory in AD animals. …”
Get full text
Get full text

Single-cell dissection of the human brain vasculature by Garcia, Francisco J, Sun, Na, Lee, Hyeseung, Godlewski, Brianna, Mathys, Hansruedi, Galani, Kyriaki, Zhou, Blake, Jiang, Xueqiao, Ng, Ayesha P, Mantero, Julio, Tsai, Li-Huei, Bennett, David A, Sahin, Mustafa, Kellis, Manolis, Heiman, Myriam

“…Despite the importance of the cerebrovasculature in maintaining normal brain physiology and in understanding neurodegeneration and drug delivery to the central nervous system1, human cerebrovascular cells remain poorly characterized owing to their sparsity and dispersion. …”
Get full text

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease by Matsushima, Ayano, Pineda, Sergio Sebastian, Crittenden, Jill R, Lee, Hyeseung, Galani, Kyriakitsa, Mantero, Julio, Tombaugh, Geoffrey, Kellis, Manolis, Heiman, Myriam, Graybiel, Ann M

“…It is well established that the indirect-pathway SPNs are susceptible to neurodegeneration and transcriptomic disturbances, but less is known about how the striosome-matrix axis is compromised in HD in relation to the canonical axis. …”
Get full text

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes by Colombo, Gloria, Cubero, Ryan John A, Kanari, Lida, Venturino, Alessandro, Schulz, Rouven, Scolamiero, Martina, Agerberg, Jens, Mathys, Hansruedi, Tsai, Li-Huei, Chachólski, Wojciech, Hess, Kathryn, Siegert, Sandra

“…This sex-specific phenotype declines with maturation but increases over the disease trajectories in two neurodegeneration mouse models, with females showing a faster morphological shift in affected brain regions. …”
Get full text

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease by Chen, Rongqing, Zhang, Jian, Wu, Yan, Wang, Dongqing, Feng, Guoping, Tang, Ya-Ping, Teng, Zhaoqian, Chen, Chu

“…MAGL inhibition also prevented neuroinflammation, decreased neurodegeneration, maintained integrity of hippocampal synaptic structure and function, and improved long-term synaptic plasticity, spatial learning, and memory in AD animals. …”
Get full text
Get full text

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis by Pimplikar, Sanjay W., Nixon, Ralph A., Robakis, Nikolaos K., Shen, Jie, Tsai, Li-Huei

“…Here we summarize the studies showing how amyloid-independent mechanisms cause defective endo-lysosomal trafficking, altered intracellular signaling cascades, or impaired neurotransmitter release and contribute to synaptic dysfunction and/or neurodegeneration, leading to dementia in AD. A view of AD pathogenesis that encompasses both the amyloid-dependent and -independent mechanisms will help fill the gaps in our knowledge and reconcile the findings that cannot be explained solely by the amyloid hypothesis.…”
Get full text
Get full text

Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia by Sako, W., Morigaki, R., Kaji, R., Tooyama, I., Okita, S., Kitazato, K., Nagahiro, S., Goto, S., Graybiel, Ann M.

“…The neuron-specific isoform of the TAF1 gene (N-TAF1) is thought to be involved in the pathogenesis of DYT3 dystonia, which leads to progressive neurodegeneration in the striatum. To determine the expression pattern of N-TAF1 transcripts, we developed a specific monoclonal antibody against the N-TAF1 protein. …”
Get full text
Get full text

Negative Regulation of Vps34 by Cdk Mediated Phosphorylation by Furuya, Tsuyoshi, Kim, Minsu, Lipinski, Marta, Li, Juying, Kim, Dohoon, Lu, Tao, Shen, Yong, Rameh, Lucia, Yankner, Bruce, Tsai, Li-Huei, Yuan, Junying

“…We propose that phosphorylation of Thr159 in Vps34 is a key regulatory mechanism that controls the class III PtdIns3 kinase activity in cell-cycle progression, development, and human diseases including neurodegeneration and cancers.…”
Get full text
Get full text