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Investigating habits: strategies, technologies and models
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Genome Editing Technologies: Defining a Path to Clinic
Published 2017Get full text
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Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies
Published 2016“…The efficiency of assisted reproductive technologies (ARTs) in nonhuman primates is low due to no screening criterions for selecting sperm, oocyte, and embryo as well as its surrogate mothers. …”
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Development of CRISPR-Cas systems for genome editing and beyond
Published 2022“…These new discoveries in turn spurred further technological developments. I review these exciting discoveries and technologies as well as provide an overview of the broad array of applications of these technologies in basic research and in the improvement of human health. …”
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A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance
Published 2023“…Point-of-care (POC) nucleic acid detection technologies are poised to aid gold-standard technologies in controlling the COVID-19 pandemic, yet shortcomings in the capability to perform critically needed complex detection-such as multiplexed detection for viral variant surveillance-may limit their widespread adoption. …”
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Structure and engineering of the minimal type VI CRISPR-Cas13bt3
Published 2023“…Type VI CRISPR-Cas13 effector enzymes catalyze RNA-guided RNA cleavage and have been harnessed for various technologies, such as RNA detection, targeting, and editing. …”
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Structural Supervision Improves Learning of Non-Local Grammatical Dependencies
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Genome-scale neurogenetics: methodology and meaning
Published 2017“…After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. …”
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Mapping core similarity among visual objects across image modalities
Published 2016“…Humans have devised a wide range of technologies for creating visual representations of real-world objects. …”
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Molecular Tools and Approaches for Optogenetics
Published 2016“…Recent developments in optogenetics technology have begun to address this challenge by enabling precise perturbation of distinct cell types based on molecular signatures, functional projections, and intracellular biochemical signaling pathways. …”
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Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research
Published 2021“…The recently developed new genome-editing technologies, such as the CRISPR/Cas system, have opened the door for generating genetically modified nonhuman primate (NHP) models for basic neuroscience and brain disorders research. …”
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An Overview of Bayesian Methods for Neural Spike Train Analysis
Published 2015“…With the advancement of multielectrode recording and imaging technologies, it has become increasingly demanding to develop statistical tools for analyzing large neuronal ensemble spike activity. …”
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Effect of correlations on network controllability
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Multiplex Genome Engineering Using CRISPR/Cas Systems
Published 2016“…Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. …”
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An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
Published 2021“…Our design makes use of recently developed technologies to reduce the complexity of the drive while maintaining a low weight. …”
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