Organometallic palladium reagents for cysteine bioconjugation by Vinogradova, Ekaterina V., Zhang, Chi, Spokoyny, Alexander M., Pentelute, Bradley L., Buchwald, Stephen Leffler

“…Here we report that palladium(II) complexes can be used for efficient and highly selective cysteine conjugation (bioconjugation) reactions that are rapid and robust under a range of bio-compatible reaction conditions. …”
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The Palladium-Catalyzed Trifluoromethylation of Vinyl Sulfonates by Cho, Eun Jin, Buchwald, Stephen Leffler

“…A method for the palladium-catalyzed trifluoromethylation of cyclohexenyl sulfonates has been developed. …”
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Palladium-Mediated Arylation of Lysine in Unprotected Peptides by Lee, Hong Geun, Lautrette, Guillaume, Pentelute, Bradley L., Buchwald, Stephen Leffler

“…In the presence of a preformed biarylphosphine-supported palladium(II)–aryl complex and a weak base, lysine amino groups underwent C−N bond formation at room temperature. …”
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Palladium–peptide oxidative addition complexes for bioconjugation by Rojas, Anthony J, Wolfe, Justin M, Dhanjee, Heemal H, Buslov, Ivan, Truex, Nicholas L, Liu, Richard Y, Massefski, Walter, Pentelute, Bradley L, Buchwald, Stephen L

“…<jats:p>Peptides bearing palladium oxidative addition complexes can be synthesized from the parent aryl halide containing substrates and react with thiol functional groups of small molecules, peptides, and proteins at low micromolar concentrations.…”
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Palladium(0)-Catalyzed Arylative Dearomatization of Phenols by Rousseaux, Sophie, Garcia-Fortanet, Jorge, Del Aguila Sanchez, Miguel Angel, Buchwald, Stephen Leffler

“…The palladium-catalyzed arylative dearomatization of phenols to yield spirocyclohexadienone products in good to excellent yields has been developed. …”
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Palladium-Catalyzed N-Arylation of 2-Aminothiazoles by McGowan, Meredeth A., Henderson, Jaclyn L., Buchwald, Stephen Leffler

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Palladium-Catalyzed Asymmetric Dearomatization of Naphthalene Derivatives by Kessler, Florian, Garcia-Fortanet, Jorge, Buchwald, Stephen Leffler

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Palladium-Catalyzed Synthesis of N-Aryl Carbamates by Fors, Brett P., Vinogradova, Ekaterina, Park, Nathaniel Hamilton, Buchwald, Stephen Leffler

“…An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with sodium cyanate. …”
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Palladium-Catalyzed Amination of Unprotected Halo-7- azaindoles by Henderson, Jaclyn L., McDermott, Sarah M., Buchwald, Stephen Leffler

“…Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.…”
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Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogs by Tsvelikhovsky, Dmitry, Buchwald, Stephen Leffler

“…In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. …”
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Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation by Reilly, John, Rojas, Anthony Jose, Zhang, Chi, Vinogradova, Ekaterina V., Buchwald, Nathan, Pentelute, Bradley L., Buchwald, Stephen Leffler

“…Here we detail a method for a divergent macrocyclisation of unprotected peptides by crosslinking two cysteine residues with bis-palladium organometallic reagents. These synthetic intermediates are prepared in a single step from commercially available aryl bis-halides. …”
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Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Effect of TESCF by Ye, Yuxuan, Takada, Takashi, Buchwald, Stephen Leffler

“…A method for the palladium-catalyzed fluorination of cyclic vinyl triflates has been developed. …”
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Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions by Ruiz-Castillo, Paula, Buchwald, Stephen Leffler

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Palladium Oxidative Addition Complexes for Peptide and Protein Cross-linking by Kubota, Koji, Dai, Peng, Pentelute, Bradley L., Buchwald, Stephen Leffler

“…A new method for cysteine-lysine cross-linking in peptides and proteins using palladium oxidative addition complexes is presented. …”
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Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols by Zhang, Hong, Ruiz-Castillo, Paula, Buchwald, Stephen Leffler

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Palladium–Protein Oxidative Addition Complexes by Amine-Selective Acylation by Dhanjee, Heemal H., Buslov, Ivan, Windsor, Ian W., Raines, Ronald T., Pentelute, Bradley L., Buchwald, Stephen L.

“…© Palladium oxidative addition complexes (OACs) are traditionally accessed by treating an aryl halide-containing substrate with a palladium(0) source. …”
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Palladium-Catalyzed Conversion of Aryl and Vinyl Triflates to Bromides and Chlorides by Shen, Xiaoqiang, Hyde, Alan M., Buchwald, Stephen Leffler

“…The palladium-catalyzed conversion of aryl and vinyl triflates to aryl and vinyl halides (bromides and chlorides) has been developed using dialkylbiaryl phosphine ligands. …”
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Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides by Su, Mingjuan, Hoshiya, Naoyuki, Buchwald, Stephen Leffler

“…An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. …”
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In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides by Milner, Phillip John, Yang, Yang, Buchwald, Stephen Leffler

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A Ligand Exchange Process for the Diversification of Palladium Oxidative Addition Complexes by King, Ryan P, Krska, Shane W, Buchwald, Stephen L

“…Palladium oxidative addition complexes (OACs) have recently emerged as useful tools to enable challenging bond connections. …”
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