Regular smoking of male ancestors in adolescence and fat mass in young adult grandchildren and great-grandchildren [version 1; peer review: 1 approved, 2 approved with reservations... by Matthew Suderman, Sarah Watkins, Kate Northstone, Marcus Pembrey, Jean Golding, Yasmin Iles-Caven, Steven Gregory

“…Conclusions: We have shown associations between grandfathers’ smoking in adolescence and increased fat (but not lean) mass in their children. …”
Get full text

Regular smoking of male ancestors in adolescence and fat mass in young adult grandchildren and great-grandchildren [version 2; peer review: 1 approved, 3 approved with reservations... by Matthew Suderman, Sarah Watkins, Kate Northstone, Marcus Pembrey, Jean Golding, Yasmin Iles-Caven, Steven Gregory

“…Conclusions: We have shown associations between grandfathers’ smoking in adolescence and increased fat (but not lean) mass in their children. …”
Get full text

A history of asthma may be associated with grandparents’ exposures to stress and cigarette smoking by Jean Golding, Holly Tunstall, Steve Gregory, Raquel Granell, James W. Dodd, Yasmin Iles-Caven, Sarah Watkins, Matthew Suderman

“…A few studies have assessed whether asthma has ancestral associations with exposure to cigarette smoking, but results have been mixed so far.Material and methods: In this study we used four generations: (F0 great-grandparents, F1 grandparents, F2 parents, F3 study children) of the Avon Longitudinal Study of Parents and Children (ALSPAC) to determine whether there is evidence of associations between asthma in generations F2 or F3 and exposures to severe trauma in childhood and/or active cigarette smoking during the adolescence of grandmothers and grandfathers in generations F0 and F1 respectively, or of a history of a F0 or F1 grandmother smoking during pregnancy.Results: We have shown that: a) stress exemplified by the death of a F1 grandparent’s parent during the grandparents’ childhood was associated with increased risk of asthma in generation F3, especially if the grandparent involved was the paternal grandmother; b) if the grandparents of generations F0 or F1 smoked during adolescence (i.e. …”
Get full text