Diffusion tensor imaging defines subregions of human lateral premotor cortex with distinct frontoparietal connections by Tomassini, V, Jbabdi, S, Klein, J, Behrens, T, Rushworth, M, Matthews, P, Palace, J, Johansen-Berg, H

Regional white matter integrity differentiates between vascular dementia and Alzheimer disease. by Zarei, M, Damoiseaux, J, Morgese, C, Beckmann, C, Smith, S, Matthews, P, Scheltens, P, Rombouts, SA, Barkhof, F

“…METHODS: T1-weighted and diffusion-tensor imaging scans were obtained in 13 VaD patients, 16 AD patients, and 22 healthy elderly controls. …”

DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease. by Douaud, G, Jbabdi, S, Behrens, T, Menke, R, Gass, A, Monsch, A, Rao, A, Whitcher, B, Kindlmann, G, Matthews, P, Smith, S

“…Here we report whole-brain findings from a comprehensive study of diffusion tensor indices and probabilistic tractography obtained in a very large population of healthy controls, MCI and probable AD subjects. …”

Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimer's disease. by Zarei, M, Patenaude, B, Damoiseaux, J, Morgese, C, Smith, S, Matthews, P, Barkhof, F, Rombouts, SA, Sanz-Arigita, E, Jenkinson, M

“…Here we combined shape analysis and diffusion tensor imaging (DTI) tractography to study degeneration in AD in the thalamus and its connections. …”

Functional and structural changes in the memory network associated with left temporal lobe epilepsy. by Voets, N, Adcock, J, Stacey, R, Hart, Y, Carpenter, K, Matthews, P, Beckmann, C

“…Nine pre-operative patients with intractable left TLE and 10 healthy controls underwent functional MRI during complex scene encoding. Diffusion tensor imaging was additionally performed in the same patients. …”

Characterization and propagation of uncertainty in diffusion-weighted MR imaging. by Behrens, T, Woolrich, M, Jenkinson, M, Johansen-Berg, H, Nunes, R, Clare, S, Matthews, P, Brady, J, Smith, S

“…This technique is applied to the estimation of parameters in the diffusion tensor model, and also to a simple partial volume model of diffusion. …”

Two-dimensional population map of cortical connections in the human internal capsule. by Zarei, M, Johansen-Berg, H, Jenkinson, M, Ciccarelli, O, Thompson, A, Matthews, P

“…MATERIALS AND METHODS: Diffusion tensor imaging (DTI) was carried out on 11 healthy volunteers. …”

New approaches for exploring anatomical and functional connectivity in the human brain. by Ramnani, N, Behrens, T, Penny, W, Matthews, P

“…Here, we highlight recent advances in neuroimaging methodology that have made it possible to investigate the anatomical architecture of networks in the living human brain with diffusion tensor imaging (DTI). We also highlight recent thinking on the ways in which functional imaging can be used to characterize information transmission across networks in the human brain (functional and effective connectivity).…”

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. by Behrens, T, Johansen-Berg, H, Woolrich, M, Smith, S, Wheeler-Kingshott, C, Boulby, P, Barker, G, Sillery, E, Sheehan, K, Ciccarelli, O, Thompson, A, Brady, J, Matthews, P

“…Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has previously been used to define large white-matter tracts in the living human brain, but this technique has had limited success in tracing pathways into gray matter. …”

Connectivity-based segmentation of the substantia Nigra in human and its implications in Parkinson's disease. by Menke, R, Jbabdi, S, Miller, K, Matthews, P, Zarei, M

“…We acquired quantitative T1 as well as diffusion tensor imaging (DTI) data from ten healthy subjects and ten PD patients. …”

Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease by Matthews, P, Filippini, N, Douaud, G

“…Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. …”

Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease. by Matthews, P, Filippini, N, Douaud, G

“…Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. …”

Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease by Matthews, P, Filippini, N, Douaud, G

“…Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. …”

Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease. by Menke, R, Jbabdi, S, Miller, K, Matthews, P, Zarei, M

“…We acquired quantitative T1 as well as diffusion tensor imaging (DTI) data from ten healthy subjects and ten PD patients. …”

Longitudinal changes in grey and white matter during adolescence. by Giorgio, A, Watkins, K, Chadwick, M, James, S, Winmill, L, Douaud, G, De Stefano, N, Matthews, P, Smith, S, Johansen-Berg, H, James, A

“…We also performed tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data to test for age-related WM changes across the whole brain. …”

MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. by Menke, R, Scholz, J, Miller, K, Deoni, S, Jbabdi, S, Matthews, P, Zarei, M

“…We also investigated whether additional measures that can be obtained with diffusion tensor imaging (DTI) can further improve the MRI-guided discrimination between PD patients and controls. …”

Walking performance and its recovery in chronic stroke in relation to extent of lesion overlap with the descending motor tract. by Dawes, H, Enzinger, C, Johansen-Berg, H, Bogdanovic, M, Guy, C, Collett, J, Izadi, H, Stagg, C, Wade, D, Matthews, P

“…Lesion volumes were manually defined on high resolution T1-weighted 3T-MRI scans and a probabilistic map of the corticospinal tract created using diffusion tensor imaging data collected previously in healthy subjects. …”

Abnormal connectivity of the sensorimotor network in patients with MS: a multicenter fMRI study. by Rocca, M, Absinta, M, Valsasina, P, Ciccarelli, O, Marino, S, Rovira, A, Gass, A, Wegner, C, Enzinger, C, Korteweg, T, Sormani, M, Mancini, L, Thompson, A, De Stefano, N, Montalban, X, Hirsch, J, Kappos, L, Ropele, S, Palace, J, Barkhof, F, Matthews, P, Filippi, M

“…In a subgroup of subjects, diffusion tensor (DT) MRI metrics of the corpus callosum and the left corticospinal tract (CST) were also assessed. …”

Model-free characterization of brain functional networks for motor sequence learning using fMRI. by Tamás Kincses, Z, Johansen-Berg, H, Tomassini, V, Bosnell, R, Matthews, P, Beckmann, C

“…Subjects practiced a 10-digit, visually cued, fixed motor sequence during 15 consecutive 30 s practice blocks interleaved with similarly cued random sequence blocks. Tensor Independent Component Analysis (TICA) decomposed the data into statistically independent spatio-temporal processes. …”

Discordant white matter N-acetylasparate and diffusion MRI measures suggest that chronic metabolic dysfunction contributes to axonal pathology in multiple sclerosis. by Cader, S, Johansen-Berg, H, Wylezinska, M, Palace, J, Behrens, T, Smith, S, Matthews, P

“…We found a strong correlation between callosal size and both mean FA (r=0.68, p<0.005) (related specifically to changes in the radial tensor component) and mean inter-hemispheric motor tract connectivity probability (r=0.74, p<0.001). …”