HLA-B27-RESTRICTED PEPTIDE PRESENTATION TO CYTOTOXIC T-CELLS IN REACTIVE ARTHRITIS by Bowness, P, Allen, R, Mcmichael, A, Edmunds, S, Hall, M, Bowman, S, Wordsworth, B

T-CELL RECEPTOR USAGE OF SYNOVIAL LYMPHOCYTES FROM A PATIENT WITH REACTIVE ARTHRITIS by Bowness, P, Wordsworth, B, Moss, P, Mcmichael, A, Bell, J

Homocysteine modification of HLA antigens and its immunological consequences. by Gao, X, Wordsworth, P, Mcmichael, A, Kyaw, M, Seifert, M, Rees, D, Dougan, G

“…Homocysteine-treated cells can be specifically lysed by cytotoxic T lymphocytes (CTL) identifiable in patients with ankylosing spondylitis and reactive arthritis. Sensitization of target cells involves disulfide bonding and the interaction between homocysteine and HLA antigens occurs in a pre-Golgi compartment in the cells. …”

Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes. by Tan, L, Mowat, A, Fazou, C, Rostron, T, Roskell, H, Dunbar, P, Tournay, C, Romagné, F, Peyrat, M, Houssaint, E, Bonneville, M, Rickinson, AB, Mcmichael, A, Callan, M

“…RESULTS: The first group of 15 patients included 10 patients with RA, one patient with reactive arthritis, one patient with psoriatic arthritis and three patients with osteoarthritis. …”