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Biological Mechanism(s) Underpinning the Association between Antipsychotic Drugs and Weight Gain
Published 2021-09-01“…The list of genes involved in the lipid pathways that correlated with weight gain was enriched for genes transcriptionally regulated by <i>SREBF1</i> and <i>SREBF2</i>. Furthermore, quetiapine significantly increased the expression of <i>SREBF1</i> and <i>SREBF2</i> in NT-2 cells. …”
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Transcriptional Effects of Psychoactive Drugs on Genes Involved in Neurogenesis
Published 2020-11-01“…Neuronal-like cells (NT2-N) were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), or valproate (0.5 mM) for 24 h. …”
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Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia
Published 2021-07-01“…In this study, neuronal-like NT2 cells were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM), or vehicle control for 24 h. …”
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Effects of Psychotropic Drugs on Ribosomal Genes and Protein Synthesis
Published 2022-06-01“…We treated human neuronal-like (NT2-N) cells with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM) or vehicle control for 24 h. …”
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