A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture by Imakaev, Maksim Viktorovich, Mirny, Leonid A

“…Chromatin loops and domains have been detected in mouse zygotes by single-nucleus Hi-C (snHi-C), but not bulk Hi-C. …”
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Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition by Flyamer, Ilya M., Gassler, Johanna, Brandão, Hugo B., Ulianov, Sergey V., Razin, Sergey V., Tachibana-Konwalski, Kikuë, Imakaev, Maksim Viktorovich, Abdennur, Nezar Alexander, Mirny, Leonid A

“…Chromatin is reprogrammed after fertilization to produce a totipotent zygote with the potential to generate a new organism. …”
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The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos by Erceg, Jelena, AlHaj Abed, Jumana, Goloborodko, Anton, Lajoie, Bryan R., Fudenberg, Geoffrey, Abdennur, Nezar Alexander, Imakaev, Maksim Viktorovich, McCole, Ruth B., Nguyen, Son C., Saylor, Wren, Joyce, Eric F., Senaratne, T. Niroshini, Hannan, Mohammed A., Nir, Guy, Dekker, Job, Mirny, Leonid A, Wu, C.-ting

“…We also find a significant genome-wide correlation between pairing, transcription during zygotic genome activation, and binding of the pioneer factor Zelda. …”
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MCM complexes are barriers that restrict cohesin-mediated loop extrusion by Dequeker, Bart JH, Scherr, Matthias J, Brandão, Hugo B, Gassler, Johanna, Powell, Sean, Gaspar, Imre, Flyamer, Ilya M, Lalic, Aleksandar, Tang, Wen, Stocsits, Roman, Davidson, Iain F, Peters, Jan-Michael, Duderstadt, Karl E, Mirny, Leonid A, Tachibana, Kikuë

“…Single-nucleus Hi-C (high-resolution chromosome conformation capture) of mouse zygotes reveals that MCM loading reduces CTCF-anchored loops and decreases TAD boundary insulation, which suggests that loop extrusion is impeded before reaching CTCF. …”
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