Ibuprofen with or without an antiemetic for acute migraine headaches in adults by Rabbie, R, Derry, S, Moore, R

“…For ibuprofen 400 mg versus placebo, NNTs for 2-hour pain-free (26% versus 12% with placebo), 2-hour headache relief (57% versus 25%) and 24-hour sustained headache relief (45% versus 19%) were 7.2, 3.2 and 4.0, respectively. …”

Ibuprofen with or without an antiemetic for acute migraine headaches in adults. by Rabbie, R, Derry, S, Moore, R, McQuay, H

“…For ibuprofen 400 mg versus placebo, NNTs for 2-hour pain-free (26% versus 12% with placebo), 2-hour headache relief (57% versus 25%) and 24-hour sustained headache relief (45% versus 19%) were 7.2, 3.2 and 4.0, respectively. …”

Aspirin with or without an antiemetic for acute migraine headaches in adults. by Kirthi, V, Derry, S, Moore, R, McQuay, H

“…For all efficacy outcomes, all active treatments were superior to placebo, with NNTs of 8.1, 4.9 and 6.6 for 2-hour pain-free, 2-hour headache relief, and 24-hour headache relief with aspirin alone versus placebo, and 8.8, 3.3 and 6.2 with aspirin plus metoclopramide versus placebo. …”

Aspirin with or without an antiemetic for acute migraine headaches in adults. by Kirthi, V, Derry, S, Moore, R

“…For all efficacy outcomes, all active treatments were superior to placebo, with NNTs of 8.1, 4.9 and 6.6 for 2-hour pain-free, 2-hour headache relief, and 24-hour headache relief with aspirin alone versus placebo, and 8.8, 3.3 and 6.2 with aspirin plus metoclopramide versus placebo. …”

Aspirin with or without an antiemetic for acute migraine headaches in adults. by Kirthi, V, Derry, S, Moore, R

“…For all efficacy outcomes, all active treatments were superior to placebo, with NNTs of 8.1, 4.9 and 6.6 for 2-hour pain-free, 2-hour headache relief, and 24-hour headache relief with aspirin alone versus placebo, and 8.8, 3.3 and 6.2 with aspirin plus metoclopramide versus placebo. …”

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. by Derry, S, Moore, R, McQuay, H

“…Nausea, photophobia and phonophobia were reduced more with paracetamol than with placebo at 2 hours (NNTs of 7 to 11); more individuals were free of any functional disability at 2 hours with paracetamol (NNT 10); and fewer participants needed rescue medication over 6 hours (NNT 6).Paracetamol 1000 mg plus metoclopramide 10 mg was not significantly different from oral sumatriptan 100 mg for 2-hour headache relief; there were no 2-hour pain-free data. …”

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. by Derry, S, Moore, R

“…For all efficacy outcomes paracetamol was superior to placebo, with NNTs of 12 (19% response with paracetamol, 10% with placebo), 5.0 (56% response with paracetamol, 36% with placebo) and 5.2 (39% response with paracetamol, 20% with placebo) for 2-hour pain-free and 2- and 1-hour headache relief, respectively, when medication was taken for moderate to severe pain.Paracetamol 1000 mg plus metoclopramide 10 mg was not significantly different from oral sumatriptan 100 mg for 2-hour headache relief; there were no 2-hour pain-free data.Adverse event rates were similar between paracetamol and placebo, and between paracetamol plus metoclopramide and sumatriptan. …”

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. by Derry, S, Moore, R

“…For all efficacy outcomes paracetamol was superior to placebo, with NNTs of 12 (19% response with paracetamol, 10% with placebo), 5.0 (56% response with paracetamol, 36% with placebo) and 5.2 (39% response with paracetamol, 20% with placebo) for 2-hour pain-free and 2- and 1-hour headache relief, respectively, when medication was taken for moderate to severe pain.Paracetamol 1000 mg plus metoclopramide 10 mg was not significantly different from oral sumatriptan 100 mg for 2-hour headache relief; there were no 2-hour pain-free data.Adverse event rates were similar between paracetamol and placebo, and between paracetamol plus metoclopramide and sumatriptan. …”

Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. by Derry, C, Derry, S, Moore, R

“…For sumatriptan 6 mg versus placebo the NNTs were 2.9, 2.3, 2.2, and 2.1 for pain-free at one and two hours, and headache relief at one and two hours, respectively, and 6.1 for sustained pain-free at 24 hours. …”

Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. by Toms, L, Derry, S, Moore, R, McQuay, H

“…Time to use of rescue medication was over four hours with paracetamol plus codeine and two hours with placebo. …”

Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. by Toms, L, Derry, S, Moore, R, McQuay, H

“…Time to use of rescue medication was over four hours with paracetamol plus codeine and two hours with placebo. …”

Oral morphine for cancer pain. by Wiffen, P, Wee, B, Moore, R

“…Fourteen studies compared Mm/r in different strengths; six of these included 24-hour modified release products. Fifteen studies compared Mm/r with other opioids. …”

Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibupro... by Moore, R, Straube, S, Paine, J, Derry, S, McQuay, H

“…Etoricoxib 120 mg (NNT for ≥50% maximum 6-hour pain relief 1.7) and ibuprofen 200/400 mg plus paracetamol 500/1000 mg (NNTs 1.5 and 1.6, respectively) produced the lowest (best) NNTs in the dental pain model. …”

Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen/paracetamol... by Moore, R, Straube, S, Paine, J, Derry, S, McQuay, H

“…Etoricoxib 120 mg (NNT for ≥ 50% maximum 6-hour pain relief 1.7) and ibuprofen 200/400 mg plus paracetamol 500/1000 mg (NNTs 1.5 and 1.6, respectively) produced the lowest (best) NNTs in the dental pain model. …”

Sumatriptan (rectal route of administration) for acute migraine attacks in adults. by Derry, C, Derry, S, Moore, R

“…The NNTs for sumatriptan 25 mg versus placebo were 4.2, 3.2, and 2.4 for pain-free at two hours, headache relief at one hour, and headache relief at two hours, respectively.Relief of functional disability was greater with sumatriptan than with placebo, with NNTs of 8.0 and 4.0 for the 12.5 mg and 25 mg doses, respectively. …”

Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review by Barden, J, Edwards, J, McQuay, H, Moore, R

“…Mean time to remedication (weighted by trial size) was >24 hours with valdecoxib 40 mg, 8.7 hours with parecoxib 40 mg IV and 1.7 to 1.8 hours with placebo. …”

Single-dose rofecoxib for acute postoperative pain in adults: a quantitative systematic review by Barden, J, Edwards, J, McQuay, H, Moore, R

“…The weighted mean remedication time was 1.9 hours for placebo (126 patients), 7.4 hours for ibuprofen 400 mg (97 patients) and 13.6 hours for rofecoxib 50 mg (322 patients). …”

Single dose oral diflunisal for acute postoperative pain in adults. by Wasey, J, Derry, S, Moore, R, McQuay, H

“…MAIN RESULTS: Nine studies in dental, orthopedic and gynaecological surgery met the inclusion criteria, testing doses of diflunisal from 125 mg to 1000 mg.For diflunisal 1000 mg, the NNT for at least 50% pain relief over 4 to 6 hours was 2.1 (1.8 to 2.6) (6 studies, 391 participants); the NNT to prevent remedication within 6 hours was 1.9 (1.7 to 2.3), and within 12 hours was 2.2 (1.9 to 2.7) (6 studies, 409 participants). …”

Intravenous or intramuscular parecoxib for acute postoperative pain in adults. by Lloyd, R, Derry, S, Moore, R, McQuay, H

“…Median time to use of rescue medication was 3.1 hours, 6.9 hours and 10.6 hours with parecoxib 10 mg, 20 mg and 40 mg respectively, and 1.5 hours with placebo. …”

Single dose oral lumiracoxib for postoperative pain in adults. by Roy, Y, Derry, S, Moore, R

“…With lumiracoxib 400 mg 50% of participants had at least 50% pain relief over six hours, compared with 8% given placebo; RB 6.9 (95% CI 4.1 to 12), NNT 2.4 (2.1 to 2.8).Median time to onset of analgesia was shorter for lumiracoxib 400 mg (0.6 to 1.5 hours) than placebo (>12 hours). …”