Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults by Gaskell, H, Derry, S, Moore, R, McQuay, H, Moore, M

“…Background: Oxycodone is a strong opioid agonist used to treat severe pain. …”

Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. by Gaskell, H, Derry, S, Moore, R, McQuay, H

“…BACKGROUND: Oxycodone is a strong opioid agonist used to treat severe pain. …”

Single dose oral ibuprofen plus oxycodone for acute postoperative pain in adults. by Derry, S, Derry, C, Moore, R

“…For ibuprofen 400 mg alone the proportion was 50%, producing no significant difference between ibuprofen 400 mg + oxycodone 5 mg and ibuprofen 400 mg alone. For oxycodone 5 mg alone the proportion was 23%, giving an NNT for ibuprofen 400 mg + oxycodone 5 mg compared with oxycodone alone of 2.9 (2.3 to 4.0).Ibuprofen + oxycodone resulted in longer times to remedication than with placebo. …”

Opioids for cancer pain - an overview of Cochrane reviews. by Wiffen, P, Wee, B, Derry, S, Bell, R, Moore, R

“…</p> <h4> <p>Reviews on buprenorphine, codeine with or without paracetamol, hydromorphone,methadone, tramadol with or without paracetamol, tapentadol, and oxycodone did not have information about the primary outcome of mild or no pain at 14 days, although that on oxycodone indicated that average pain scores were within that range. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”