LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain by Jun Sung Park, Kamran Saeed, Myeung Hoon Jo, Min Woo Kim, Hyeon Jin Lee, Chan-Bae Park, Gwang Lee, Myeong Ok Kim

“…Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. …”
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Nicotinamide Ameliorates Amyloid Beta-Induced Oxidative Stress-Mediated Neuroinflammation and Neurodegeneration in Adult Mouse Brain by Inayat Ur Rehman, Riaz Ahmad, Ibrahim Khan, Hyeon Jin Lee, Jungsung Park, Rahat Ullah, Myeong Jun Choi, Hee Young Kang, Myeong Ok Kim

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Pharmacological Inhibition of Spleen Tyrosine Kinase Suppressed Neuroinflammation and Cognitive Dysfunction in LPS-Induced Neurodegeneration Model by Min Woo Kim, Kyonghwan Choe, Jun Sung Park, Hyeon Jin Lee, Min Hwa Kang, Riaz Ahmad, Myeong Ok Kim

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Systematic Review of the Common Pathophysiological Mechanisms in COVID-19 and Neurodegeneration: The Role of Bioactive Compounds and Natural Antioxidants by Kyonghwan Choe, Hyun Young Park, Muhammad Ikram, Hyeon Jin Lee, Tae Ju Park, Rahat Ullah, Myeong Ok Kim

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Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment by Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim

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Establishing Co-Culture Blood–Brain Barrier Models for Different Neurodegeneration Conditions to Understand Its Effect on BBB Integrity by Jun Sung Park, Kyonghwan Choe, Amjad Khan, Myeung Hoon Jo, Hyun Young Park, Min Hwa Kang, Tae Ju Park, Myeong Ok Kim

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Lupeol, a Plant-Derived Triterpenoid, Protects Mice Brains against Aβ-Induced Oxidative Stress and Neurodegeneration by Riaz Ahmad, Amjad Khan, Hyeon Jin Lee, Inayat Ur Rehman, Ibrahim Khan, Sayed Ibrar Alam, Myeong Ok Kim

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Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling by Shafiq Ur Rehman, Muhammad Ikram, Najeeb Ullah, Sayed Ibrar Alam, Hyun Young Park, Haroon Badshah, Kyonghwan Choe, Myeong Ok Kim

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Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions by Muhammad Ikram, Myeung Hoon Jo, Kyonghwan Choe, Amjad Khan, Sareer Ahmad, Kamran Saeed, Min Woo Kim, Myeong Ok Kim

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Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ₁–₄₂-Induced Alzheimer’s Disease by Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim

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Antioxidant and Anti-Inflammatory Effects of <i>Citrus</i> Flavonoid Hesperetin: Special Focus on Neurological Disorders by Amjad Khan, Muhammad Ikram, Jong Ryeal Hahm, Myeong Ok Kim

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17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway by Ibrahim Khan, Kamran Saeed, Min Gi Jo, Myeong Ok Kim

“…The study aimed to explain the neuroprotective role of E2 against glutamate-induced ROS production, MAP kinase-dependent neuroinflammation, synaptic dysfunction and neurodegeneration in the cortex and hippocampus of postnatal day 7 rat brain. …”
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Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice by Waqar Ali, Muhammad Ikram, Hyun Young Park, Min Gi Jo, Rahat Ullah, Sareer Ahmad, Noman Bin Abid, Myeong Ok Kim

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Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain by Jong Ryeal Hahm, Myeung Hoon Jo, Rahat Ullah, Min Woo Kim, Myeong Ok Kim

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Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling by Muhammad Ikram, Tae Ju Park, Tahir Ali, Myeong Ok Kim

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Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury by Sayed Ibrar Alam, Min Gi Jo, Tae Ju Park, Rahat Ullah, Sareer Ahmad, Shafiq Ur Rehman, Myeong Ok Kim

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17β-Estradiol Modulates SIRT1 and Halts Oxidative Stress-Mediated Cognitive Impairment in a Male Aging Mouse Model by Mehtab Khan, Rahat Ullah, Shafiq Ur Rehman, Shahid Ali Shah, Kamran Saeed, Tahir Muhammad, Hyun Young Park, Myeung Hoon Jo, Kyonghwan Choe, Bart P.F. Rutten, Myeong Ok Kim

Subjects: “…neuroinflammation neurodegeneration…”
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Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson’s Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment by Abubakar Atiq, Hyeon Jin Lee, Amjad Khan, Min Hwa Kang, Inayat Ur Rehman, Riaz Ahmad, Muhammad Tahir, Jawad Ali, Kyonghwan Choe, Jun Sung Park, Myeong Ok Kim

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Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders by Muhammad Ikram, Rahat Ullah, Amjad Khan, Myeong Ok Kim

“…Years of research have suggested that gintonin has antioxidant and anti-inflammatory effects against different models of neurodegeneration, and these effects may be employed to tackle the neurological changes. …”
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17β-Estradiol Abrogates Oxidative Stress and Neuroinflammation after Cortical Stab Wound Injury by Kamran Saeed, Myeung Hoon Jo, Jun Sung Park, Sayed Ibrar Alam, Ibrahim Khan, Riaz Ahmad, Amjad Khan, Rahat Ullah, Myeong Ok Kim

“…Here, in the current study, we investigated the hypothesis that 17β-estradiol could rescue the mouse brain against apoptotic cell death and neurodegeneration by suppressing deleterious proinflammatory response probably by abrogating metabolic stress and oxidative damage after brain injury. …”
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