GENERAL PRINCIPLES OF TREATMENT FOR MUSCULOSKELETAL PAIN: INTERDISCIPLINARY CONSENSUS by E. L. Nasonov, N. N. Yakhno, A. E. Karateev, L. I. Alekseeva, A. N. Barinov, A. E. Barulin, O. S. Davydov, A. B. Danilov, M. V. Zhuravleva, B. V. Zavodovsky, S. S. Kopenkin, M. L. Kukishkin, V. A. Parfenov, M. A. Strakhov, V. P. Tyurin, N. V. Chichasova, S. A. Chorbinskaya

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Therapy for locomotor apparatus diseases: Efficiency and safety by N. V. Chichasova

“…Requirements for long-term drug therapy that can reduce the degree of inflammation and pain are determined by the magnitude of the analgesic and anti-inflammatory effect and safety of drugs. …”
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Treatment in patients with osteoarthritis at different sites: Place of slow-acting drugs by N. V. Chichasova, G. R. Imametdinоva

“…The main goal of osteoarthritis (OA) treatment is to perform rational analgesic and anti-inflammatory therapy, to slow down the progression of the disease, and to preserve quality of life in patients. …”
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Intra-articular glucocorticoid injection site: best practice guidelines by N. V. Chichasova, A. M. Lila

“…The mechanisms of action of locally administered glucocorticoids leading to anti-inflammatory and analgesic effects are described. The comparative characteristics of locally administered glucocorticoids with different duration of action according to their effectiveness and safety are presented. …”
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MODERN OSTEOARTHRITIS THERAPY: ALFLUTOP IN CLINICAL PRACTICE, EXPERIMENTAL AND CLINICAL DATA by N. V. Chichasova

“…The data of numerous clinical studies (including the double blind placebo-controlled) show that it has an expressed analgesic effect, developing in the first weeks after administration in osteoarthritis patients, including with periarthrites, osteochondrosis, with back pain of different genesis, and the existence of the anti-inflammatory effect and a positive impact on the quality of life of osteoarthritis patients. …”
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NEW ASPECTS OF TREATING CHRONIC PAIN: MULTICENTER, OPEN-LABEL CLINICAL TRIAL OF MEDICATION KETONAL DUO IN PATIENTS WITH DEGENERATIVE JOINT DISEASES by N. V. Chichasova, R. G. Kamalova, T. V. Plaksina, A. A. Popov

“…The medication demonstrated a reliable analgesic effect and good tolerance; adverse events were observed in 4.7% of patients. …”
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The 2014 guidelines for the management of osteoarthritis: Place of hyaluronic acid preparations by N. V. Chichasova, G. R. Imametdinova

“…The paper demonstrates benefits in surviving the analgesic effect of hylan G-F 20 versus intraarticular administration of glucocorticoids.…”
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The problem in the evaluation of the efficacy and safety of nonsteroidal anti-inflammatory drugs by N. V. Chichasova

“…The members of the International Consensus Group concluded that nimesulide, if properly used, remained a valuable and safe drug for the treatment of various conditions, characterized by the presence of acute inflammatory pain, by virtue of the rapid onset of analgesic action and an evidence-based positive benefit/risk profile. …”
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Modern approaches to the treatment of osteoarthritis by N. V. Chichasova

“…Ability of Alflutop to supress the mediators of inflammation, such as interleukins 6 and 8, and degradations at osteoarthritis, as well as to stimulate the proliferation and renewal of chondrocytes is shown according to the results of an international experimental study, explaining its ability to cause a quick analgesic and anti-inflammatory effect. Alflutop inhibits in vitro extracellular release of the pro-inflammatory cytokine interleukin 6 (IL-6) for 16 per cent and chemokine IL-8 for 35 per cent, inhibits pro-angiogenic factor VEGF for 56 per cent, has an antioxidant effect, which contributes to the synthesis of cartilage macromolecules, a decrease in the activity of matrix metalloproteases (MMPs), a decrease in the concentration of prostaglandins and leukotrienes, and a decrease in chondrocyte apoptosis. …”
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Safe therapy of osteoarthritis: place of topical nonsteroidal anti-inflammatory drugs by N. V. Chichasova, G. R. Imametdinova, A. M. Lila

“…The article discusses the social significance of osteoarthritis as a widespread disease that develops mainly in older people, which makes it difficult to carry out anti-inflammatory and analgesic therapy due to the frequent combination of osteoarthritis with other diseases at this age, the need to treat comorbid conditions, which is often poorly combined with systemic therapy with non-steroidal anti-inflammatory drugs. …”
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Alflutop in osteoarthritis therapy by G. V. Lukina, J A Sigidin, N. V. Chichasova, G. R. Imametdinova, T. B. Lobzanidse, O. V. Pushkova, M. V. Severinova, E S Mach, D. V. Reshetnyak

“…Combined Im and AT administration provides anti-inflammatory, analgesic and possible chondroprotective effect in OA pts.…”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…The drug is shown to have a rapid analgesic and anti-inflammatory effect, as well as a positive influence on all clinical manifestations of OA.…”
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Clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice» by A. E. Karateev, E. L. Nasonov, N. N. Yakhno, V. T. Ivashkin, N. V. Chichasova, L. I. Alekseeva, Yu. A. Karpov, M. A. Evseev, M. L. Kukushkin, A. B. Danilov, O. V. Vorobyeva, A. V. Amelin, D. S. Novikova, O. M. Drapkina, S. S. Kopenkin, G. R. Abuzarova

“…The paper presents the new version of the clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice » prepared by the Association of Rheumatologists of Russia, the Russian Pain Society, the Russian Gastroenterological Association, the Russian Society of Cardiology, the Association of Traumatologists and Orthopedists of Russia, the Association of Interdisciplinary Medicine, and the Russian Association of Palliative Medicine.In our country, NSAIDs are the most important and most popular class of analgesics. Unlike global practice, Russian physicians rather rarely recommend paracetamol as a first-line drug to relieve moderate or severe pain, by giving preference to NSAIDs; the use of opioid analgesics for noncancers is minimized because of tight legal restrictions.NSAIDs are effective and easy-to-use; however, they are far from safe; the administration of these medications may lead to serious gastrointestinal, cardiovascular, renal, and other complications in a number of cases. …”
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