Cerebral malaria in children. by Newton, C

Plasma and cerebrospinal proteomes from children with cerebral malaria differ from those of children with other encephalopathies. by Gitau, E, Kokwaro, G, Karanja, H, Newton, C, Ward, SA

“…Clinical signs and symptoms of cerebral malaria in children are nonspecific and are seen in other common encephalopathies in malaria-endemic areas. …”

Intravenous fluids for seriously ill children. by Maitland, K, Newton, C, English, M

The challenges and innovations for therapy in children with epilepsy. by Wilmshurst, J, Berg, A, Lagae, L, Newton, C, Cross, J

“…Major advances have been made in the diagnosis, evaluation and management of children with epilepsy over the past 15 years. There has been a marked increase in genetic diagnoses of a number of key childhood-onset epilepsy syndromes, such as Dravet syndrome, which has been linked to mutations in the SCN1A gene. …”

Epileptic seizures and malaria in Kenyan children. by Waruiru, C, Newton, C, Forster, D, New, L, Winstanley, P, Mwangi, I, Marsh, V, Winstanley, M, Snow, R, Marsh, K

“…During this period, 1324 children were studied, of whom 15.8% had seizures as part of their illness. …”

The challenges and innovations for therapy in children with epilepsy by Wilmshurst, J, Berg, A, Lagae, L, Newton, C, Cross, J

“…Major advances have been made in the diagnosis, evaluation and management of children with epilepsy over the past 15 years. There has been a marked increase in genetic diagnoses of a number of key childhood-onset epilepsy syndromes, such as Dravet syndrome, which has been linked to mutations in the SCN1A gene. …”

Management of seizures in children with falciparum malaria. by Ogutu, B, Newton, C

“…Falciparum malaria is the most common cause of convulsions in children admitted to hospital in malaria endemic areas. …”

The challenges of managing children with epilepsy in Africa. by Wilmshurst, J, Kakooza-Mwesige, A, Newton, C

“…Children with epilepsy who reside in the African continent are faced with some of the greatest challenges of receiving adequate care. …”

Hypokalemia in children with severe falciparum malaria. by Maitland, K, Pamba, A, Newton, C, Lowe, B, Levin, M

“…At admission, serum potassium was normal (3-5.5 mmol/L) in 31 (81.6%) and low (<3 mmol/L) in four (11%) children, and three (6.3%) children had hyperkalemia (>5.5 mmol/L). …”

Chloramphenicol pharmacokinetics in African children with severe malaria. by Kokwaro, G, Muchohi, SN, Ogutu, B, Newton, C

“…The objective of this study was to determine if the current dosage regimen for chloramphenicol CAP administered to children with severe malaria SM for presumptive treatment of concomitant bacterial meningitis achieves steady state plasma CAP concentrations within the reported therapeutic range of 10-25 mg/l. …”

Coma scales for children with severe falciparum malaria. by Newton, C, Chokwe, T, Schellenberg, J, Winstanley, P, Forster, D, Peshu, N, Kirkham, F, Marsh, K

“…The Blantyre coma scale (BCS) is used to assess children with severe falciparum malaria, particularly as a criterion for cerebral malaria, but it has not been formally validated. …”

Management of severe falciparum malaria in African children. by Newton, C

Indicators of life-threatening malaria in African children. by Marsh, K, Forster, D, Waruiru, C, Mwangi, I, Winstanley, M, Marsh, V, Newton, C, Winstanley, P, Warn, P, Peshu, N

“… BACKGROUND: About 90 percent of the deaths from malaria are in African children, but criteria to guide the recognition and management of severe malaria have not been validated in them. …”

Seizures in 204 comatose children: incidence and outcome. by Kirkham, F, Wade, A, McElduff, F, Boyd, S, Tasker, R, Edwards, M, Neville, BG, Peshu, N, Newton, C

“…PURPOSE: Seizures are common in comatose children, but may be clinically subtle or only manifest on continuous electroencephalographic monitoring (cEEG); any association with outcome remains uncertain. …”

The management of severe malaria in children: a review. by Murphy, S, English, M, Omar, A, Crawley, J, Waruiru, C, Mwangi, I, Amukoye, E, Peshu, N, Newton, C, Winstanley, P

Intracranial pressure in African children with cerebral malaria. by Newton, C, Kirkham, F, Winstanley, P, Pasvol, G, Peshu, N, Warrell, D, Marsh, K

“…Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. …”

Pentoxifylline as an adjunct therapy in children with cerebral malaria. by Lell, B, Köhler, C, Wamola, B, Olola, C, Kivaya, E, Kokwaro, G, Wypij, D, Mithwani, S, Taylor, T, Kremsner, P, Newton, C

“… BACKGROUND: Pentoxifylline (PTX) affects many processes that may contribute to the pathogenesis of severe malaria and it has been shown to reduce the duration of coma in children with cerebral malaria. This pilot study was performed to assess pharmacokinetics, safety and efficacy of PTX in African children with cerebral malaria. …”

Behavioral problems in children with epilepsy in rural Kenya. by Kariuki, S, Abubakar, A, Holding, P, Mung'ala-Odera, V, Chengo, E, Kihara, M, Neville, BG, Newton, C

“…The aims of this study were to record behavioral problems in children with epilepsy (CWE), compare the prevalence with that reported among healthy children without epilepsy, and investigate the risk factors. …”

Seizures in 204 comatose children: incidence and outcome by Kirkham, F, Wade, A, McElduff, F, Boyd, S, Tasker, R, Edwards, M, Neville, B, Peshu, N, Newton, C

Neurological features of falciparum malaria in African children by Idro, R, Ndiritu, M, Newton, C