Contributions of HERG K+ current to repolarization of the human ventricular action potential. by Fink, M, Noble, D, Virag, L, Varro, A, Giles, W

“…For these reasons we and others have attempted to define the functional role for HERG-mediated K+ currents in repolarization of the action potential in the human ventricle. …”

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk by Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D

“…While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold of their hERG inhibitory concentration 50% (IC50) values has been suggested, there are drugs that are exceptions to this rule: hERG inhibitors that do not cause TdP, and drugs that can cause TdP but are not strong hERG inhibitors. …”

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. by Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D

“…While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold of their hERG inhibitory concentration 50% (IC(50)) values has been suggested, there are drugs that are exceptions to this rule: hERG inhibitors that do not cause TdP, and drugs that can cause TdP but are not strong hERG inhibitors. …”

Investigation of the cellular pharmacological mechanism and clinical evidence of the multi-herbal antiarrhythmic chinese medicine Xin Su Ning by Ma, Y-L, Hu, R-M, Yang, X, Wang, T, Noble, PJ, Wilkins, R, Ellory, C, Carr, C, Noble, D

“…In conclusion, XSN is an effective multicomponent antiarrhythmic medicine to treat PVC without adverse effect in patients, which is convincingly supported by its class I & III pharmacological antiarrhythmic mechanism of blocking hERG potassium channels and hNaV1.5 sodium channel reported in our earlier publication and prolongs AP duration both in ventricular myocytes and with computational simulation of human AP presented in this report.…”