Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment by Francesco Buonfiglio, Norbert Pfeiffer, Adrian Gericke

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Twenty-Years of Experience in Childhood Glaucoma Surgery by Felix Mathias Wagner, Alexander Karl-Georg Schuster, Franz Grehn, Lukas Urbanek, Norbert Pfeiffer, Julia Verena Stingl, Esther Maria Hoffmann

Subjects: “…glaucoma…”
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Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways by Nadine Auler, Henrik Tonner, Norbert Pfeiffer, Franz H. Grus

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A generalizable deep learning regression model for automated glaucoma screening from fundus images by Ruben Hemelings, Bart Elen, Alexander K. Schuster, Matthew B. Blaschko, João Barbosa-Breda, Pekko Hujanen, Annika Junglas, Stefan Nickels, Andrew White, Norbert Pfeiffer, Paul Mitchell, Patrick De Boever, Anja Tuulonen, Ingeborg Stalmans

“…Abstract A plethora of classification models for the detection of glaucoma from fundus images have been proposed in recent years. …”
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A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma by Henrik Tonner, Selina Hunn, Nadine Auler, Carsten Schmelter, Vanessa M. Beutgen, Harald D. von Pein, Norbert Pfeiffer, Franz H. Grus

Subjects: “…glaucoma…”
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Long-term success after trabeculectomy in open-angle glaucoma: results of a retrospective cohort study by Norbert Pfeiffer, Alexander K Schuster, Julia Stingl, Esther M Hoffmann, Felix Mathias Wagner, Keywan Kianusch

“…Objective To evaluate the long-term outcomes of trabeculectomy (TE) surgery in a large cohort with a minimum follow-up of 3 years.Design Retrospective cohort study.Setting University Eye Hospital, Germany.Participants Three hundred and seventy-nine patients with open-angle glaucoma underwent TE with mitomycin C (MMC) between January 2013 and February 2017 with a minimal follow-up of 3 years. …”
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Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma by Henrik Tonner, Selina Hunn, Nadine Auler, Carsten Schmelter, Norbert Pfeiffer, Franz H. Grus

Subjects: “…glaucoma…”
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Influence of different primary surgical techniques on long-term intraocular pressure and medication in glaucoma after congenital cataract surgery. by Alicja Strzalkowska, Piotr Strzalkowski, Julia V Stingl, Norbert Pfeiffer, Alexander K Schuster, Esther M Hoffmann

“…<h4>Purpose</h4>To assess long-time results of primary surgical treatment in children with glaucoma after congenital cataract surgery.<h4>Methods</h4>A retrospective study of 37 eyes from 35 children with glaucoma after congenital cataract surgery, who underwent surgery between 2011 and 2021 at the Childhood Glaucoma Center, University Medical Center Mainz, Germany. …”
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Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1 by Kristian Nzogang Fomo, Carsten Schmelter, Joshua Atta, Vanessa M. Beutgen, Rebecca Schwarz, Natarajan Perumal, Gokul Govind, Thomas Speck, Norbert Pfeiffer, Franz H. Grus

Subjects: “…glaucoma…”
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Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A) by Carsten Schmelter, Kristian Nzogang Fomo, Alina Brueck, Natarajan Perumal, Sascha D. Markowitsch, Gokul Govind, Thomas Speck, Norbert Pfeiffer, Franz H. Grus

Subjects: “…glaucoma…”
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Muscarinic Acetylcholine Receptors in the Retina—Therapeutic Implications by Yue Ruan, Andreas Patzak, Norbert Pfeiffer, Adrian Gericke

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Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases? by Francesco Buonfiglio, Elsa Wilma Böhm, Norbert Pfeiffer, Adrian Gericke

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Short-Term Omega-3 Supplementation Modulates Novel Neurovascular and Fatty Acid Metabolic Proteome Changes in the Retina and Ophthalmic Artery of Mice with Targeted <i>Cyp2c44</i>... by Natarajan Perumal, Anna Herfurth, Norbert Pfeiffer, Caroline Manicam

“…The potential adjunct use of ω-3 PUFA for glaucoma therapy needs further investigation.…”
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Methods to measure blood flow and vascular reactivity in the retina by Elsa Wilma Böhm, Norbert Pfeiffer, Felix Mathias Wagner, Adrian Gericke

“…Disturbances of retinal perfusion are involved in the onset and maintenance of several ocular diseases, including diabetic retinopathy, glaucoma, and retinal vascular occlusion. Hence, knowledge on ocular vascular anatomy and function is highly relevant for basic research studies and for clinical judgment and treatment. …”
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Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases by Elsa Wilma Böhm, Nils F. Grauhan, Norbert Pfeiffer, Adrian Gericke

“…Abnormal retrobulbar hemodynamics have been linked to the development of various ocular diseases, including glaucoma, age-related macular degeneration, and diabetic retinopathy. …”
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Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Networks in Retinal Tissues by Carsten Schmelter, Kristian Nzogang Fomo, Natarajan Perumal, Norbert Pfeiffer, Franz H. Grus

“…In accordance with this, our group verified in a recent study that the synthetic peptide ASGYTFTNYGLSWVR, encoding the hypervariable sequence part of an antibody, showed a high affinity for the target protein HTRA2 and triggered neuroprotection in an in vitro organ culture model for glaucoma. To unravel this neuroprotective mechanism, the present study showed for the first time that the synthetic CDR1 peptide significantly (<i>p</i> < 0.01) inhibited the proteolytic activity of HTRA2 up to 50% using a specific protease function assay. …”
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