Population pharmacokinetics of mefloquine in patients with acute falciparum malaria. by Simpson, J, Price, R, ter Kuile, F, Teja-Isavatharm, P, Nosten, F, Chongsuphajaisiddhi, T, Looareesuwan, S, Aarons, L, White, N

“…OBJECTIVE: To construct a population pharmacokinetic model for mefloquine in the treatment of falciparum malaria. …”

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. by Miotto, O, Almagro-Garcia, J, Manske, M, Macinnis, B, Campino, S, Rockett, K, Amaratunga, C, Lim, P, Suon, S, Sreng, S, Anderson, J, Duong, S, Nguon, C, Chuor, C, Saunders, D, Se, Y, Lon, C, Fukuda, M, Amenga-Etego, L, Hodgson, A, Asoala, V, Imwong, M, Takala-Harrison, S, Nosten, F, Su, X

“…We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. …”

Postpartum thiamine deficiency in a Karen displaced population. by Mcgready, R, Simpson, J, Cho, T, Dubowitz, L, Changbumrung, S, Böhm, V, Munger, R, Sauberlich, H, White, N, Nosten, F

Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria. by Tarning, J, Zongo, I, Somé, F, Rouamba, N, Parikh, S, Rosenthal, P, Hanpithakpong, W, Jongrak, N, Day, N, White, N, Nosten, F, Ouedraogo, J, Lindegardh, N

“…Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling. The population pharmacokinetics of piperaquine were described accurately by a two-transit-compartment absorption model and a three-compartment distribution model. …”

Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria by Tarning, J, Zongo, I, Somé, F, Rouamba, N, Parikh, S, Rosenthal, P, Hanpithakpong, W, Jongrak, N, Day, N, White, N, Nosten, F, Ouedraogo, J, Lindegardh, N

“…Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling. The population pharmacokinetics of piperaquine were described accurately by a two-transit-compartment absorption model and a three-compartment distribution model. …”

Human Plasmodium vivax diversity, population structure and evolutionary origin by Rougeron, V, Elguero, E, Arnathau, C, Acuña Hidalgo, B, Durand, P, Houze, S, Berry, A, Zakeri, S, Haque, R, Alam, MS, Nosten, F, Severini, C, Woldearegai, TG, Mordmüller, B, Kremsner, PG, González-Cerón, L, Fontecha, G, Gamboa, D, Musset, L, Legrand, E, Noya, O, Pumpaibool, T, Harnyuttanakorn, P, Lekweiry, KM, Albsheer, MM, Hamid, MMA, Boukary, AOMS, Trape, J-F, Renaud, F, Prugnolle, F

“…We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. …”

Population pharmacokinetic and pharmacodynamic modeling of artemisinin resistance in Southeast Asia by Lohy Das, J, Dondorp, A, Nosten, F, Phyo, A, Hanpithakpong, W, Ringwald, P, Lim, P, White, N, Karlsson, M, Bergstrand, M, Tarning, J

Extreme neonatal hyperbilirubinaemia in refugee and migrant populations: retrospective cohort by Wouda, EMN, Thielemans, L, Darakamon, MC, Nge, AA, Say, W, Khing, S, Hanboonkunupakarn, B, Ngerseng, T, Landier, J, van Rheenen, PF, Turner, C, Nosten, F, McGready, R, Carrara, VI

“…<br></br> Setting Special care baby unit in a refugee camp and clinics for migrant populations at the Thailand–Myanmar border with phototherapy facilities but limited access to exchange transfusion (ET). …”

Population genetic correlates of declining transmission in a human pathogen. by Nkhoma, S, Nair, S, Al-Saai, S, Ashley, E, Mcgready, R, Phyo, A, Nosten, F, Anderson, T

“…Pathogen control programs provide a valuable, but rarely exploited, opportunity to directly examine the relationship between population decline and population genetics. We investigated the impact of an ~12-fold decline in transmission on the population genetics of Plasmodium falciparum infections (n = 1731) sampled from four clinics on the Thai-Burma border over 10 years and genotyped using 96 genome-wide SNPs. …”

The epidemiology of malaria in a Karen population on the western border of Thailand. by Luxemburger, C, Thwai, K, White, N, Webster, H, Kyle, D, Maelankirri, L, Chongsuphajaisiddhi, T, Nosten, F

“…From November 1991 to November 1992 a prospective, descriptive study of malaria epidemiology was conducted in a Karen population on the western border of Thailand. Two study groups were selected at random and more than 80% of the subjects were followed for one year. …”

Determinants of preterm birth, small for gestational age and foetal growth in a marginalized populations on Thai-Myanmar border: a 30 year population cohort study by Min, AM

“…As these findings emerged from this thesis three strategies have been implemented in the population: i) avoiding repeat teenage pregnancy after childbirth, ii) aspirin and calcium for prevention of pre-eclampsia and iii) most recently screening all women for gestational diabetes using a two-step approach. …”

Population pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants by Wattanakul, T, Gilder, ME, McGready, R, Hanpithakpong, W, Day, NPJ, White, NJ, Nosten, F, Tarning, J, Hoglund, RM

POPULATION PHARMACOKINETICS OF ANTIMALARIAL DRUGS IN THE TREATMENT OF PREGNANT WOMEN WITH UNCOMPLICATED MALARIA by Tarning, J, Hoglund, R, Chotsiri, P, Hanpithakpong, W, Pyo, A, Jullien, V, Lindegardh, N, Rijken, M, Adam, I, Nosten, F

Linking international clinical research with stateless populations to justice in global health. by Pratt, B, Zion, D, Lwin, K, Cheah, P, Nosten, F, Loff, B

“…These insights allowed us to extend the framework to consider external research actors' obligations to stateless populations. Data analysis then showed that framework requirements are largely fulfilled in relation to the vivax malaria treatment trial by Wellcome Trust (funder), Oxford University (sponsor), and investigators. …”

Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria. by Tarning, J, Rijken, M, Mcgready, R, Phyo, A, Hanpithakpong, W, Day, N, White, N, Nosten, F, Lindegardh, N

“…The objective of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with uncomplicated malaria. …”

Population Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Malaria by Tarning, J, Rijken, M, McGready, R, Phyo, A, Hanpithakpong, W, Day, N, White, N, Nosten, F, Lindegardh, N

“…The objective of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with uncomplicated malaria. …”

Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria by Klein, K, Aarons, L, Ter Kuile, F, Nosten, F, White, N, Edstein, MD, Teja-Isavadharm, P

“…Aims To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. …”

Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria. by Klein, K, Aarons, L, Ter Kuile, F, Nosten, F, White, N, Edstein, MD, Teja-Isavadharm, P

“…AIMS: To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. …”

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda. by Kloprogge, F, Jullien, V, Piola, P, Dhorda, M, Muwanga, S, Nosten, F, Day, N, White, N, Guerin, P, Tarning, J

“…Plasma samples were collected daily and at frequent intervals after the first and last doses. A population pharmacokinetic model for quinine was developed accounting for different disposition, absorption, error and covariate models. …”

Population Pharmacokinetics and Antimalarial Pharmacodynamics of Piperaquine in Patients With Plasmodium vivax Malaria in Thailand. by Tarning, J, Thana, P, Phyo, A, Lwin, K, Hanpithakpong, W, Ashley, E, Day, N, Nosten, F, White, N

“…The objective of this study was to evaluate the population pharmacokinetics and pharmacodynamics of piperaquine in patients with P. vivax malaria in Thailand after a standard regimen of dihydroartemisinin-piperaquine to determine whether residual piperaquine prevents or delays the emergence of P. vivax relapse. …”