Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study by Fedirko, V, Tran, H, Gewirtz, A, Stepien, M, Trichopoulou, A, Aleksandrova, K, Olsen, A, Tjønneland, A, Overvad, K, Carbonnel, F, Boutron-Ruault, M, Severi, G, Kühn, T, Kaaks, R, Boeing, H, Bamia, C, Lagiou, P, Grioni, S, Panico, S, Palli, D, Tumino, R, Naccarati, A, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Castaño, J, Barricarte, A, Sánchez, M, Dorronsoro, M, Quirós, J, Agudo, A, Sjöberg, K, Ohlsson, B, Hemmingsson, O, Werner, M, Bradbury, K, Khaw, K, Wareham, N, Tsilidis, K, Aune, D, Scalbert, A, Romieu, I, Riboli, E, Jenab, M

“…</p><p>METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. …”

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. by Grote, V, Kaaks, R, Nieters, A, Tjønneland, A, Halkjær, J, Overvad, K, Skjelbo Nielsen, MR, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodríguez, L, Duell, E, Sánchez, M

“…METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. …”

Exposure to ambient air pollution and the risk of inflammatory bowel disease: a European nested case-control study by Opstelten, J, Beelen, R, Leenders, M, Hoek, G, Brunekreef, B, van Schaik, F, Siersema, P, Eriksen, K, Raaschou-Nielsen, O, Tjønneland, A, Overvad, K, Boutron-Ruault, M, Carbonnel, F, de Hoogh, K, Key, T, Luben, R, Chan, S, Hart, A, Bueno-de-Mesquita, H, Oldenburg, B

Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort by Fortner, RT, Sarink, D, Schock, H, Johnson, T, Tjønneland, A, Olsen, A, Overvad, K, Affret, A, His, M, Boutron-Ruault, MC, Boeing, H, Trichopoulou, A, Naska, A, Orfanos, P, Palli, D, Sieri, S, Mattiello, A, Tumino, R, Ricceri, F, Bueno-de-Mesquita, HB, Peeters, PH, Van Gils, CH, Weiderpass, E, Lund, E, Quirós, JR, Agudo, A, Sánchez, MJ, Chirlaque, MD, Ardanaz, E, Dorronsoro, M, Key, T, Khaw, KT, Rinaldi, S, Dossus, L, Gunter, M, Merritt, MA, Riboli, E, Kaaks, R

“…Circulating OPG and breast cancer risk has been examined in only one prior study.A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study. by Fedirko, V, Duarte-Salles, T, Bamia, C, Trichopoulou, A, Aleksandrova, K, Trichopoulos, D, Trepo, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Kvaskoff, M, Kühn, T, Lukanova, A, Boeing, H, Buijsse, B, Klinaki, E, Tsimakidi, C, Naccarati, A, Tagliabue, G, Panico, S, Tumino, R, Palli, D, Bueno-de-Mesquita, H

“…Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

KIM-1 as a blood-based marker for early detection of kidney cancer: a prospective nested case–control study by Scelo, G, Muller, DC, Riboli, E, Johansson, M, Cross, AJ, Vineis, P, Tsilidis, KK, Brennan, P, Boeing, H, Peeters, PHM, Vermeulen, RCH, Overvad, K, Bueno-De-Mesquita, HB, Severi, G, Perduca, V, Kvaskoff, M, Trichopoulou, A, La Vecchia, C, Karakatsani, A, Palli, D, Sieri, S, Panico, S, Weiderpass, E, Sandanger, TM, Nøst, TH, Agudo, A, Quirós, JR, Rodríguez-Barranco, M, Chirlaque, M-D, Key, TJ, Khanna, P, Bonventre, JV, Sabbisetti, VS, Bhatt, RS

“…</p> <p><strong>Experimental Design:</strong> KIM-1 concentrations were measured in prediagnostic plasma from 190 RCC cases and 190 controls nested within a population-based prospective cohort study. …”

Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. by James, R, Lukanova, A, Dossus, L, Becker, S, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Engel, P, Clavel-Chapelon, F, Chang-Claude, J, Vrieling, A, Boeing, H, Schütze, M, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Rodríguez, L, Buckland, G

“…In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. …”

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Prediagnostic serum vitamin D levels and the risk of Crohn’s disease and ulcerative colitis in European populations: a nested case-control study by Opstelten, J, Chan, S, Hart, A, Van Schaik, F, Siersema, P, Lentjes, E, Khaw, K, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Peeters, P, Verschuren, W, Witteman, B, Oldenburg, B

Primary brain tumours and specific serum immunoglobulin E: A case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort by Schlehofer, B, Siegmund, B, Linseisen, J, Schüz, J, Rohrmann, S, Becker, S, Michaud, D, Melin, B, Bas Bueno-De-Mesquita, H, Peeters, P, Vineis, P, Tjonneland, A, Olsen, A, Overvad, K, Romieu, I, Boeing, H, Aleksandrova, K, Trichopoulou, A, Bamia, C, Lagiou, P, Sacerdote, C, Palli, D, Panico, S, Sieri, S, Tumino, R

“…Methods: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. …”

Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort. by Schlehofer, B, Siegmund, B, Linseisen, J, Schüz, J, Rohrmann, S, Becker, S, Michaud, D, Melin, B, Bas Bueno-de-Mesquita, H, Peeters, P, Vineis, P, Tjonneland, A, Olsen, A, Overvad, K, Romieu, I, Boeing, H, Aleksandrova, K, Trichopoulou, A, Bamia, C, Lagiou, P, Sacerdote, C, Palli, D, Panico, S, Sieri, S, Tumino, R

“…METHODS: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. …”

Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. by Leufkens, A, van Duijnhoven, F, Woudt, S, Siersema, P, Jenab, M, Jansen, E, Pischon, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V

“…This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). …”

Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition by Crowe, F, Allen, N, Appleby, P, Overvad, K, Aardestrup, I, Johnsen, N, Tjønneland, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Zavitsanou, A, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Agnoli, C, Kiemeney, L, Bueno-de-Mesquita, H, Chirlaque, M, Ardanaz, E, Larrañaga, N, Quirós, JR, Sánchez, M

“…Objective: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. Design: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. by Crowe, F, Allen, N, Appleby, P, Overvad, K, Aardestrup, I, Johnsen, N, Tjønneland, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Zavitsanou, A, Trichopoulos, D, Sacerdote, C, Palli, D, Tumino, R, Agnoli, C, Kiemeney, L, Bueno-de-Mesquita, H, Chirlaque, MD, Ardanaz, E, Larrañaga, N, Quirós, JR, Sánchez, M

“…OBJECTIVE: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. DESIGN: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Soluble receptor for advanced glycation end-products (sRAGE) and colorectal cancer risk: a case–control study nested within a European prospective cohort by Aglago, EK, Rinaldi, S, Freisling, H, Jiao, L, Hughes, DJ, Fedirko, V, Schalkwijk, CG, Weiderpass, E, Dahm, CC, Overvad, K, Eriksen, AK, Kyrø, C, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Katzke, V, Kühn, T, Schulze, MB, Aleksandrova, K, Masala, G, Krogh, V, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, B, van Gils, CH, Sandanger, TM, Gram, IT, Skeie, G, Quirós, JR, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Ardanaz, E, Johansson, I, Harlid, S, Perez-Cornago, A, Mayén, A-L, Cordova, R, Gunter, MJ, Vineis, P, Cross, AJ, Riboli, E, Jenab, M

“…</p> <p><strong>Methods:</strong> To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study by Huang, J, Zagai, U, Hallmans, G, Nyrén, O, Engstrand, L, Stolzenberg-Solomon, R, Duell, E, Overvad, K, Katzke, V, Kaaks, R, Jenab, M, Park, J, Murillo, R, Trichopoulou, A, Lagiou, P, Bamia, C, Bradbury, K, Riboli, E, Aune, D, Tsilidis, K, Capellá, G, Agudo, A, Krogh, V, Palli, D, Panico, S, Weiderpass, E, Tjønneland, A, Olsen, A, Martínez, B, Redondo-Sanchez, D, Chirlaque, M, Hm Peeters, P, Regnér, S, Lindkvist, B, Naccarati, A, Ardanaz, E, Larrañaga, N, Boutron-Ruault, M, Rebours, V, Barré, A, Bueno-de-Mesquita, H, Ye, W

“…The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. …”

Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. by Sinilnikova, O, McKay, J, Tavtigian, S, Canzian, F, DeSilva, D, Biessy, C, Monnier, S, Dossus, L, Boillot, C, Gioia, L, Hughes, D, Jensen, M, Overvad, K, Tjonneland, A, Olsen, A, Clavel-Chapelon, F, Chajès, V, Joulin, V, Linseisen, J, Chang-Claude, J, Boeing, H, Dahm, S, Trichopoulou, A, Trichopoulos, D, Koliva, M

“…We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency &gt;5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. …”