Thalamic neurodegeneration in multiple sclerosis. by Cifelli, A, Arridge, M, Jezzard, P, Esiri, M, Palace, J, Matthews, P

Inflammation versus neurodegeneration: consequences for treatment. by Palace, J

“…Inflammation is assumed to be the main driver of neurodegeneration in multiple sclerosis. However there is evidence that questions this hypothesis: Data from pathological studies and from imaging have shown that neuronal/axonal damage occurs early in lesion formation and at the earliest clinical stage of the disease. …”

Thalamic neurodegeneration in relapsing-remitting multiple sclerosis. by Wylezinska, M, Cifelli, A, Jezzard, P, Palace, J, Alecci, M, Matthews, P

Thalamic neurodegeneration in relapsing: Remitting multiple sclerosis by Cifelli, A, Wylezinska, M, Jezzard, P, Palace, J, Alecci, M, Matthews, P

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex by Yates, R, Esiri, M, Palace, J, Jacobs, B, Perera, R, De Luca, G

“…The aim of this study was to investigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship with neurodegeneration. METHODS: A post-mortem cohort of pathologically confirmed MS (n=47) and control (n=10) cases was used. …”

AMILORIDE TREATMENT AMELIORATES MRI SURROGATE MARKERS OF NEURODEGENERATION IN PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS by Arun, T, Sbdarella, E, Ruiter, M, Tomassini, V, Leite, M, Craner, M, Fugger, L, Jenkinson, M, Palace, J

Age-related small vessel disease: A potential contributor to neurodegeneration in multiple sclerosis by Geraldes, R, Esiri, M, DeLuca, G, Palace, J

“…Several lines of evidence suggest that an interaction between MS and SVD may influence MS-related neurodegeneration. SVD may contribute to hypoperfusion, reduced vascular reactivity and tissue hypoxia, features seen in MS. …”

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology. by Kolasinski, J, Stagg, C, Chance, SA, Deluca, G, Esiri, M, Chang, E, Palace, J, McNab, J, Jenkinson, M, Miller, K, Johansen-Berg, H

“…One hypothesis is that anatomical connectivity influences the spread of neurodegeneration. This predicts that measures of neurodegeneration will correlate most strongly between interconnected structures. …”

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology by Kolasinski, J, Stagg, C, Chance, S, DeLuca, G, Esiri, M, Chang, E, Palace, J, McNab, J, Jenkinson, M, Miller, K, Johansen-Berg, H

“…One hypothesis is that anatomical connectivity influences the spread of neurodegeneration. This predicts that measures of neurodegeneration will correlate most strongly between interconnected structures. …”

Targeting ASIC1 in primary progressive multiple sclerosis: Evidence of neuroprotection with amiloride by Arun, T, Tomassini, V, Sbardella, E, De Ruiter, M, Matthews, L, Leite, M, Gelineau-Morel, R, Cavey, A, Vergo, S, Craner, M, Fugger, L, Rovira, A, Jenkinson, M, Palace, J

“…Neurodegeneration is the main cause for permanent disability in multiple sclerosis. …”

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride. by Arun, T, Tomassini, V, Sbardella, E, de Ruiter, M, Matthews, L, Leite, M, Gelineau-Morel, R, Cavey, A, Vergo, S, Craner, M, Fugger, L, Rovira, A, Jenkinson, M, Palace, J

“…Neurodegeneration is the main cause for permanent disability in multiple sclerosis. …”

Novel imaging biomarkers for the diagnosis and study of Neuromyelitis optica by Matthews, LAE

“…</li><li>NMO is not associated with diffuse global neurodegeneration in the non-lesioned CNS tissue over a one-year period as determined by serial MRI.…”

Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy. by Palace, J

“…The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identified to date, appear to play only a moderate role. …”

Anterior optic pathway pathology in CNS demyelinating diseases by Pisa, M, Pansieri, J, Yee, S, Ruiz, J, Leite, IM, Palace, J, Comi, G, Esiri, MM, Leocani, L, DeLuca, GC

“…Our findings suggest that chronic inflammation is frequent and leads to neurodegeneration in multiple sclerosis and neuromyelitis optica, regardless of disease stage. …”

Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy. by Blamire, A, Cader, S, Lee, M, Palace, J, Matthews, P

“…Combining MRI and MRS may therefore give a more complete picture of neurodegeneration in the spinal cord.…”

Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT) by Samadzadeh, S, Adnan, R, Berglova, P, Barzegar, M, Debrabant, B, Roikjaer, SG, Levy, M, Petzold, A, Palace, J, Flanagan, EP, Mariotto, S, Skou, ST, Froelich, A, Lotan, I, Messina, S, Geraldes, R, Asseyer, S, Stiebel-Kalish, H, Oertel, FC, Shaygannejad, V, Sahraian, MA, Kim, HJ, Bennett, JL, Böttcher, C

“…In consecutive samples we will analyze levels of inflammation and neurodegeneration markers in both fluid and cellular compartments of the peripheral blood and cerebrospinal fluid (CSF) using multiple state-of-the-art technologies, including untargeted proteomics and targeted ultrasensitive ELISA assays and quantitative reverse transcription polymerase chain reaction (RT-qPCR) as well as high-dimensional single-cell technologies i.e., mass cytometry and single-cell RNA sequencing. …”

The influence of HLA-DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter by Yates, RL, Pansieri, J, Li, Q, Bell, JS, Yee, SA, Palace, J, Esiri, MM, DeLuca, GC

“…In the current study, we sought to examine the influence of HLA-DRB1*15 on relationships between inflammation and neurodegeneration in MS. Human post-mortem MS cases (n = 47) and controls (n = 10) were used. …”