Impact of the COVID-19 Pandemic on Iron Overload Assessment by MRI in Patients with Hemoglobinopathies: The E-MIOT Network Experience by Antonella Meloni, Laura Pistoia, Amalia Lupi, Riccardo Righi, Antonino Vallone, Massimiliano Missere, Stefania Renne, Priscilla Fina, Ada Riva, Maria Rita Gamberini, Valerio Cecinati, Francesco Sorrentino, Rosamaria Rosso, Giuseppe Messina, Paolo Ricchi, Vincenzo Positano, Sophie Mavrogeni, Emilio Quaia, Filippo Cademartiri, Alessia Pepe

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Link between Genotype and Multi-Organ Iron and Complications in Children with Transfusion-Dependent Thalassemia by Antonella Meloni, Laura Pistoia, Paolo Ricchi, Maria Caterina Putti, Maria Rita Gamberini, Liana Cuccia, Giuseppe Messina, Francesco Massei, Elena Facchini, Riccardo Righi, Stefania Renne, Giuseppe Peritore, Vincenzo Positano, Filippo Cademartiri

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Setting for “Normal” Serum Ferritin Levels in Patients with Transfusion-Dependent Thalassemia: Our Current Strategy by Anna Spasiano, Antonella Meloni, Silvia Costantini, Emilio Quaia, Filippo Cademartiri, Patrizia Cinque, Alessia Pepe, Paolo Ricchi

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The Link of Pancreatic Iron with Glucose Metabolism and Cardiac Iron in Thalassemia Intermedia: A Large, Multicenter Observational Study by Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Paolo Ricchi, Valerio Cecinati, Francesco Sorrentino, Liana Cuccia, Massimo Allò, Riccardo Righi, Priscilla Fina, Ada Riva, Stefania Renne, Giuseppe Peritore, Stefano Dalmiani, Vincenzo Positano, Emilio Quaia, Filippo Cademartiri, Alessia Pepe

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Multi-Parametric Cardiac Magnetic Resonance for Prediction of Heart Failure Death in Thalassemia Major by Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Paolo Ricchi, Calogera Gerardi, Gennaro Restaino, Riccardo Righi, Vincenzo Positano, Filippo Cademartiri

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Pancreatic T2* Magnetic Resonance Imaging for Prediction of Cardiac Arrhythmias in Transfusion-Dependent Thalassemia by Antonella Meloni, Laura Pistoia, Paolo Ricchi, Vincenzo Positano, Filomena Longo, Zelia Borsellino, Valerio Cecinati, Giuseppe Messina, Elisabetta Corigliano, Rosamaria Rosso, Riccardo Righi, Giuseppe Peritore, Stefania Renne, Antonino Vallone, Filippo Cademartiri

“…We considered 813 TDT patients (36.47 ± 10.71 years, 54.6% females) enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network. MRI was used to measure hepatic, pancreatic, and cardiac iron overload (IO), to assess biventricular function and atrial dimensions, and to detect replacement myocardial fibrosis. …”
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Prognostic Role of Multiparametric Cardiac Magnetic Resonance in Neo Transfusion-Dependent Thalassemia by Antonella Meloni, Laura Pistoia, Paolo Ricchi, Aurelio Maggio, Valerio Cecinati, Filomena Longo, Francesco Sorrentino, Zelia Borsellino, Alessandra Salvo, Vincenza Rossi, Emanuele Grassedonio, Gennaro Restaino, Stefania Renne, Riccardo Righi, Vincenzo Positano, Filippo Cademartiri

“…CMR was used to quantify cardiac iron overload, biventricular function, and atrial dimensions, and to detect left ventricular (LV) replacement fibrosis. …”
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Random Forest Clustering Identifies Three Subgroups of β-Thalassemia with Distinct Clinical Severity by Angela Vitrano, Khaled M. Musallam, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio, International Working Group on Thalassemia (IWG-THAL)

“…Cluster 3 represented patients with early initiation of transfusion and iron chelation, considerable iron overload, and early mortality from heart failure. …”
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Long-term safety and erythroid response with luspatercept treatment in patients with β-thalassemia by Antonio Piga, Filomena Longo, Maria Rita Gamberini, Ersi Voskaridou, Paolo Ricchi, Vincenzo Caruso, Antonello Pietrangelo, Xiaosha Zhang, Jeevan K. Shetty, Kenneth M. Attie, Immacolata Tartaglione

“…Management of anemia with regular blood transfusions is associated with complications including iron overload. Here, we report long-term safety and efficacy results of the first clinical study of luspatercept in β-thalassemia, initiated in 2013, enrolling adults with both nontransfusion-dependent (NTD) and transfusion-dependent (TD) β-thalassemia. …”
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