Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake. by Glitsch, M, Bakowski, D, Parekh, A

“…Store-operated Ca(2+) channels, which are activated by the emptying of intracellular Ca(2+) stores, provide one major route for Ca(2+) influx. …”

Characterisation of store-operated calcium entry in a vascular endothelial cell line and impact on the production of nitric oxide by Batchelor, H

“…Depletion of endoplasmic reticulum (ER) calcium stores initiates STIM-1 translocation to defined ER-plasma membrane puncta, and subsequent Orai-STIM interaction and opening of Orai. …”

Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria. by Singaravelu, K, Nelson, C, Bakowski, D, Brito, d, Ng, S, Di Capite, J, Powell, T, Scorrano, L, Parekh, A

“…Store-operated Ca2+ channels in the plasma membrane (PM) are activated by the depletion of Ca2+ from the endoplasmic reticulum (ER) and constitute a widespread and highly conserved Ca2+ influx pathway. …”

The allergen Der p3 from house dust mite stimulates store-operated Ca2+ channels and mast cell migration through PAR4 receptors by Lin, Y, Nelson, J, Kramer, H, Parekh, A

“…Here, we show that house dust mite extract activates store-operated Ca2+ channels, a common signaling module in numerous cell types in the lung. …”

Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1. by Kar, P, Samanta, K, Kramer, H, Morris, O, Bakowski, D, Parekh, A

“…By contrast, Orai3 interacts less well with AKAP79 after store depletion, rendering it ineffective in activating NFAT. …”

Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels. by Ng, S, di Capite, J, Singaravelu, K, Parekh, A

“…Inositol trisphosphate raises cytoplasmic Ca2+ concentration by releasing Ca2+ from intracellular stores. This Ca2+ release phase is accompanied by sustained Ca2+ influx through store-operated Ca2+ release-activated Ca2+ (CRAC) channels. …”

Endoplasmic reticulum-mitochondria coupling: local Ca²⁺ signalling with functional consequences. by Bakowski, D, Nelson, C, Parekh, A

“…Plasma membrane store-operated Ca²⁺ release-activated Ca²⁺ (CRAC) channels are a widespread and conserved Ca²⁺ influx pathway, driving activation of a range of spatially and temporally distinct cellular responses. …”

Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes. by Di Capite, J, Shirley, A, Nelson, C, Bates, G, Parekh, A

“…LTC(4), the parent compound, is secreted from mast cells following Ca(2+) influx through store-operated calcium release-activated calcium (CRAC) channels. …”

Decoding of cytoplasmic Ca(2+) oscillations through the spatial signature drives gene expression. by Di Capite, J, Ng, S, Parekh, A

“…Nevertheless, only oscillations with accompanying Ca(2+) entry through store-operated CRAC channels triggered gene expression. …”

The whole‐cell Ca2+ release‐activated Ca2+ current, ICRAC, is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na+ by Samanta, K, Bakowski, D, Amin, N, Parekh, A

“…Ca2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels plays a central role in activation of a range of cellular responses over broad spatial and temporal bandwidths. …”

Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression. by Ng, S, Bakowski, D, Nelson, C, Mehta, R, Almeyda, R, Bates, G, Parekh, A

“…Physiological concentrations of the receptor agonist leukotriene C(4) (LTC(4)) evoke repetitive cytoplasmic Ca(2+) oscillations, reflecting regenerative Ca(2+) release from stores, which is sustained by Ca(2+) entry through store-operated calcium-release-activated calcium (CRAC) channels. …”

Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses. by Parekh, A

“…Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels controls a disparate array of key cellular responses. …”

Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. by Ng, S, Nelson, C, Parekh, A

“…Here, we show that in mast cells, Ca(2+) microdomains from store-operated Ca(2+) release-activated Ca(2+) channels activate expression of the transcription factor c-fos. …”

Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. by Kar, P, Bakowski, D, Di Capite, J, Nelson, C, Parekh, A

“…Although oscillations arise from regenerative Ca(2+) release, they are sustained by store-operated Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels. …”

Selective activation of the transcription factor NFAT1 by calcium microdomains near Ca2+ release-activated Ca2+ (CRAC) channels. by Kar, P, Nelson, C, Parekh, A

“…Here, we visualize NFAT1 movement in and out of the nucleus in response to transient activation of store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels in nonexcitable cells. …”

Calcium signalling in mast cells by Alswied, A

“…Inositol trisphosphate transiently increases cytosolic calcium levels by releasing calcium from its internal stores. This transient phase is followed by an influx of external calcium caused by the opening of store-operated calcium release-activated calcium (CRAC) channels in the plasma membrane. …”

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters by Lin, Y, Bakowski, D, Mirams, G, Parekh, A

“…Store-operated Ca2+ entry, involving endoplasmic reticulum Ca2+ sensing STIM proteins and plasma membrane Orai1 channels, is a widespread and evolutionary conserved Ca2+ influx pathway. …”

Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats by Li, D, Lee, C, Buckler, K, Parekh, A, Herring, N, Paterson, D

“…Depleting the endoplasmic reticulum Ca2+ store did not alter the difference of the evoked [Ca2+]i transient and decay time between young SHRs and Wistar-Kyoto rats. …”

Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats by Li, D, Lee, C, Buckler, K, Parekh, A, Herring, N, Paterson, D

“…Depleting the endoplasmic reticulum Ca store did not alter the difference of the evoked [Ca]i transient and decay time between young SHRs and Wistar-Kyoto rats. …”

Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. by Di Capite, J, Nelson, C, Bates, G, Parekh, A

“…RESULTS: Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels in polyps produced LTC(4) in a manner dependent on protein kinase C. …”