A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block by Tomek, J, Bueno-Orovio, A, Passini, E, Zhou, X, Minchole, A, Britton, O, Bartolucci, C, Severi, S, Shrier, A, Virag, L, Varro, A, Rodriguez, B

“…These insights enable the reformulation of L-type calcium current, as well as replacement of the hERG current model.…”

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities by Trovato, C, Passini, E, Nagy, N, Varro, A, Abi-Gerges, N, Severi, S, Rodriguez, B

“…Simulations demonstrate the human Purkinje Trovato2020 model is the first one to yield: (i) all key AP features consistent with human Purkinje recordings; (ii) Automaticity with funny current up-regulation (iii) EADs at slow pacing and with 85% hERG block; (iv) DADs following fast pacing; (v) conduction velocity of 160 cm/s in a Purkinje fibre, as reported in human. …”

Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias by Passini, E, Trovato, C, Morissette, P, Sannajust, F, Bueno-Orovio, A, Rodriguez, B

“…Due to its dependence on Ca2+‐transient, the EMw was also shown to be more sensitive than AP prolongation in distinguishing between pure hERG blockers and multichannel compounds also blocking the calcium current.…”