Optogenetic control of heart rhythm by selective stimulation of cardiomyocytes derived from Pnmt+ cells in murine heart by Wang, Y, Lin, W, Crawford, W, Ni, H, Bolton, E, Khan, H, Shanks, J, Bub, G, Wang, X, Paterson, D, Zhang, H, Galione, A, Ebert, S, Terrar, D, Lei, M

“…Pnmt+ cell derived cells) within the heart. Here, we show that Pnmt+ cells predominantly localized to the left side of the adult heart. …”

Endothelial nitric oxide synthase and heart rate. by Herring, N, Paterson, D

The Cardiac Physiome: at the heart of coupling models to measurement. by Smith, N, Hunter, P, Paterson, D

Tetrahydrobiopterin regulates vagal control of heart rate by Adlam, D, Danson, E, Khoo, J, Alp, N, Paterson, D, Channon, K

Organization of ventricular fibrillation in the human heart: experiments and models. by ten Tusscher, K, Mourad, A, Nash, M, Clayton, R, Bradley, C, Paterson, D, Hren, R, Hayward, M, Panfilov, A, Taggart, P

“…This number is approximately fivefold fewer compared with that observed during VF in dog and pig hearts, which are of comparable size to human hearts. …”

Mammalian γ2 AMPK regulates intrinsic heart rate by Yavari, A, Herring, N, Steeples, V, Ghaffari, S, Puliyadi, R, Beglov, Y, Kelly, M, Gehmlich, K, Douglas, G, Ferguson, D, Channon, K, Cornall, R, Paterson, D, Redwood, C, Watkins, H, Ashrafian, H

“…Humans bearing activating mutations in the γ2 subunit exhibit a phenotype including unexplained slowing of heart rate (bradycardia). Here we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (If) and ryanodine receptor-derived diastolic local subsarcolemmal Ca2+ releases. …”

Electrophysiological and proarrhythmic effects of hydroxychloroquine challenge in guinea-pig hearts by Wang, G, Lu, C-J, Trafford, AW, Tian, X, Flores, HM, Maj, P, Zhang, K, Niu, Y, Wang, L, Du, Y, Ji, X, Xu, Y, Wu, L, Li, D, Herring, N, Paterson, D, Huang, CL-H, Zhang, H, Lei, M, Hao, G

“…Effects of μM-HCQ were studied in isolated perfused guinea-pig hearts by multielectrode, optical RH237 voltage, and Rhod-2 mapping. …”

Cholinergic control of heart rate by nitric oxide is site specific. by Herring, N, Danson, E, Paterson, D

“…Parasympathetic control of heart rate involves the exocytotic release of acetylcholine and muscarinic receptor regulation of pacemaking currents. …”

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease by Habecker, B, Anderson, M, Birren, S, Fukuda, K, Herring, N, Hoover, D, Kanazawa, H, Paterson, D, Ripplinger, C

NO-cGMP dependent pathway and the modulation of vagal control of heart rate by Herring, N, Golding, S, Paterson, D

The Cardiac Physiome: At the heart of coupling models to measurement: Experimental Physiology - Introduction by Smith, N, Hunter, P, Paterson, D

PHYSICAL-TRAINING REDUCES EXERCISE-INDUCED HYPERKALEMIA IN CHRONIC HEART-FAILURE by Barlow, C, Qayyum, M, Davey, P, Conway, J, Paterson, D, Robbins, P, Sleight, P

Nitric oxide and autonomic control of heart rate: a question of specificity. by Paton, J, Kasparov, S, Paterson, D

“…There are several plausible mechanisms that might account for this specificity in the context of autonomic regulation of heart rate. NO acts at distinct levels within the autonomic nervous system to control cardiac rate, with opposing effects at different sites. …”

Targeting arterial chemoreceptor over-activity in heart failure with a gas. by Paterson, D

Differential role of nNOS in heart rate regulation between rest and exercise by Adlam, D, de Bono, J, Casadei, B, Paterson, D, Channon, K

Controlling the heart via the brain: a potential new therapy for orthostatic hypotension. by Green, A, Wang, S, Owen, S, Paterson, D, Stein, J, Aziz, T

“…Postoperatively, we continuously recorded blood pressure and heart rate with stimulation off and on and in both sitting and standing positions. …”

Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans. by Thornton, J, Aziz, T, Schlugman, D, Paterson, D

“…We studied the effects on heart rate (HR) and mean arterial blood pressure (MAP) of electrically stimulating the thalamus and basal ganglia in awake humans undergoing neurosurgery for movement disorders (n = 13 Parkinson's disease, n = 1 myoclonic dystonia, n = 1 spasmodic torticollis). …”

Ventral periaqueductal grey stimulation alters heart rate variability in humans with chronic pain. by Pereira, E, Lu, G, Wang, S, Schweder, P, Hyam, J, Stein, J, Paterson, D, Aziz, T, Green, A

“…METHODS AND RESULTS: 16 patients undergoing DBS of the rostral PAG for chronic neuropathic pain were investigated post-operatively to determine whether PAG stimulation would alter HRV, and the subjects' perception of pain. Mean heart rate together with HRV, time and frequency domain measures, low frequency (LF) and high frequency (HF) power components of heart rate and the ratio of LF to HF were calculated before and during DBS. …”

Role of nNOS in the automatic control of cardiac excitability in cardiac physiological and pathophysiological states by Heaton, D, Heaton, Daniel Anthony

Subjects:

Coronary sinus neuropeptide y levels and adverse outcomes in patients with stable chronic heart failure by Ajijola, O, Chatterjee, N, Gonzales, M, Gornbein, J, Liu, K, Li, D, Paterson, D, Shivkumar, K, Singh, J, Herring, N

“…</p> <p><strong>Main Outcomes and Measures:</strong> Chronic heart failure hospitalization, death, orthotopic heart transplantation, and ventricular assist device placement.…”