Hematopoietic stem cell development and regulatory signaling in zebrafish by Zhang, C, Patient, R, Liu, F

“…Background: Hematopoietic stem cells (HSCs) are a population of multipotent cells that can self-renew and differentiate into all blood lineages. …”

ETS transcription factors in hematopoietic stem cell development by Ciau-Uitz, A, Wang, L, Patient, R, Liu, F

“…Hematopoietic stem cells (HSCs) are essential for the maintenance of the hematopoietic system. …”

ETS transcription factors in hematopoietic stem cell development by Ciau-Uitz, A, Wang, L, Patient, R, Liu, F

“…Hematopoietic stem cells (HSCs) are essential for the maintenance of the hematopoietic system. …”

Hematopoietic stem cell development and regulatory signaling in zebrafish. by Zhang, C, Patient, R, Liu, F

“… BACKGROUND: Hematopoietic stem cells (HSCs) are a population of multipotent cells that can self-renew and differentiate into all blood lineages. …”

Origins and programming of hematopoietic stem cells in fish and frog embryos. by Ciau-Uitz, A, Walmsley, M, Gering, M, Loose, M, Patient, R

Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification. by Leung, A, Ciau-Uitz, A, Pinheiro, P, Monteiro, R, Zuo, J, Vyas, P, Patient, R, Porcher, C

“…VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. …”

Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification by Leung, A, Ciau-Uitz, A, Pinheiro, P, Monteiro, R, Zuo, J, Vyas, P, Patient, R, Porcher, C

“…VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. …”

Fev regulates hematopoietic stem cell development via ERK signaling. by Wang, L, Liu, T, Xu, L, Gao, Y, Wei, Y, Duan, C, Chen, G, Lin, S, Patient, R, Zhang, B, Hong, D, Liu, F

“…However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors has not yet been achieved. …”

Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification. by Swiers, G, Patient, R, Loose, M

“…Feed-forward motifs with autoregulation generate forward momentum and also control its rate, which is at its lowest in hematopoietic stem cells (HSCs). The simultaneous requirement for multiple regulators in multi-input motifs (MIMs) provides tight control over expression of target genes. …”

Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta. by Wilkinson, R, Pouget, C, Gering, M, Russell, A, Davies, S, Kimelman, D, Patient, R

“…Hematopoietic stem cells (HSCs) are first detected in the floor of the embryonic dorsal aorta (DA), and we investigate the signals that induce the HSC program there. …”

Ablood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos by Wang, L, Zhang, P, Wei, Y, Gao, Y, Patient, R, Liu, F

A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. by Wang, L, Zhang, P, Wei, Y, Gao, Y, Patient, R, Liu, F

Notch in the niche. by Gering, M, Patient, R

“…Notch signaling is essential for hematopoietic stem cell (HSC) formation during embryogenesis, and hitherto it was also thought to be required for HSC maintenance. …”

Transcriptional networks regulating hematopoietic cell fate decisions. by Loose, M, Swiers, G, Patient, R

“…PURPOSE OF REVIEW: We provide a summary of the temporal cascade of transcriptional networks giving rise to the hematopoietic stem cell (HSC) and controlling differentiation of the erythroid lineage from it. …”

Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. by Gering, M, Patient, R

“…Here we show that zebrafish embryos mutant in the Hh pathway or treated with the Hh signaling inhibitor cyclopamine display defects in adult hematopoietic stem cell (HSC) formation but not in primitive hematopoiesis. …”

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex. by El Omari, K, Hoosdally, S, Tuladhar, K, Karia, D, Vyas, P, Patient, R, Porcher, C, Mancini, E

“…The LIM only protein 2 (LMO2) is a key regulator of hematopoietic stem cell development whose ectopic expression in T cells leads to the onset of acute lymphoblastic leukemia. …”

Distinct origins of adult and embryonic blood in Xenopus. by Ciau-Uitz, A, Walmsley, M, Patient, R

“…The first adult hematopoietic stem cells (HSCs) are thought to form in association with the floor of the dorsal aorta, and we have detected such aortic clusters in Xenopus using hematopoietic markers. …”

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. by Luc, S, Luis, T, Boukarabila, H, Macaulay, I, Buza-Vidas, N, Bouriez-Jones, T, Lutteropp, M, Woll, P, Loughran, S, Mead, A, Hultquist, A, Brown, J, Mizukami, T, Matsuoka, S, Ferry, H, Anderson, K, Duarte, S, Atkinson, D, Soneji, S, Domanski, A, Farley, A, Sanjuan-Pla, A, Carella, C, Patient, R, de Bruijn, M

“…The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. …”

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential by Luc, S, Luis, T, Boukarabila, H, Macaulay, I, Buza-Vidas, N, Bouriez-Jones, T, Lutteropp, M, Woll, P, Loughran, S, Mead, A, Hultquist, A, Brown, J, Mizukami, T, Matsuoka, S, Ferry, H, Anderson, K, Duarte, S, Atkinson, D, Soneji, S, Domanski, A, Farley, A, Sanjuan-Pla, A, Carella, C, Patient, R, De Bruijn, M

“…The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. …”

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. by Patterson, L, Gering, M, Patient, R

“…We conclude that scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium.…”