IMGT^® Biocuration and Analysis of the Rhesus Monkey IG Loci by Viviane Nguefack Ngoune, Morgane Bertignac, Maria Georga, Ariadni Papadaki, Alexandre Albani, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida

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IMGT^® Biocuration and Comparative Analysis of <i>Bos taurus</i> and <i>Ovis aries</i> TRA/TRD Loci by Perrine Pégorier, Morgane Bertignac, Viviane Nguefack Ngoune, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida

“…The TR<inline-formula><math display="inline"><semantics><mi>α</mi></semantics></math></inline-formula> locus (TRA) and TR<inline-formula><math display="inline"><semantics><mi>δ</mi></semantics></math></inline-formula> locus (TRD) of bovine (<i>Bos taurus</i>) and the sheep (<i>Ovis aries</i>) have recently been described and annotated by IMGT^® biocurators. The aim of the present study is to present the results of the biocuration and to compare the genes of the TRA/TRD loci among these ruminant species based on the <i>Homo sapiens</i> repertoire. …”
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Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB by Taciana Manso, Anjana Kushwaha, Nika Abdollahi, Patrice Duroux, Véronique Giudicelli, Sofia Kossida

“…The characterization of these antibodies provides a comprehensive understanding of how mAbs work in cancer.MethodsIn depth biocuration taking advantage of the abundant literature data as well as amino acid sequence analyses from mAbs managed in IMGT/2Dstructure-DB, the IMGT® protein database, allowed to define a standardized and consistent description of the MOA of mAbs targeting immune checkpoints in cancer therapy.ResultsA fine description and a standardized graphical representation of the MOA of selected mAbs are integrated within IMGT/mAb-DB highlighting two main mechanisms in cancer immunotherapy, either Blocking or Agonist. …”
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