Effects of streptokinase in patients presenting within 6 hours of prolonged chest pain with ST segment depression. by Collins, R, Baigent, C, Peto, R

Reduction in infarct size, arrhythmias and chest pain by early intravenous beta blockade in suspected acute myocardial infarction. by Yusuf, S, Sleight, P, Rossi, P, Ramsdale, D, Peto, R, Furze, L, Sterry, H, Pearson, M, Motwani, R, Parish, S, Gray, R, Bennett, D, Bray, C

REDUCTION IN INFARCT SIZE, ARRHYTHMIAS AND CHEST PAIN BY EARLY INTRAVENOUS BETA-BLOCKADE IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION by Yusuf, S, Sleight, P, Rossi, P, Ramsdale, D, Peto, R, Furze, L, Sterry, H, Pearson, M, Motwani, R, Parish, S, Gray, R, Bennett, D, Bray, C

REDUCTION IN INFARCT SIZE, ARRHYTHMIAS, CHEST PAIN AND MORBIDITY BY EARLY INTRAVENOUS BETA-BLOCKADE IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION by Yusuf, S, Rossi, P, Ramsdale, D, Peto, R, Furse, L, Motwani, R, Parish, S, Gray, R, Bennett, D, Bray, C, Sleight, P

Early intravenous atenolol treatment in suspected acute myocardial infarction. Preliminary report of a randomised trial. by Yusuf, S, Ramsdale, D, Peto, R, Furse, L, Bennett, D, Bray, C, Sleight, P

“…214 patients were studied in a randomised trial to determine whether administraiton of intravenous atenolol within 12 hours of chest pain reduced eventual infarct size, as estimated by cumulative enzyme release and by ECG changes. 135 patients already had ECG evidence of infarction at entry; 72 received atenolol which significantly decreased subsequent enzyme release (atenolol and control means = 121 IU, SE +/- 10 and 177 IU, SE +/- 17; 2p < 0.005) and enhanced R-wave preservation (atenolol and control means = 46% +/- 3 and 36% +/- 3; 2p < 0.02). 79 patients had no evidence of infarction at entry; 44 did not receive atenolol and 27 of these subsequently developed infarction, whereas only 11 of 35 treated patients infarcted during their hospital stay (2p < 0.01). …”

Early intravenous atenolol treatment in suspected acute myocardial infarction. by Sleight, P, Yusuf, S, Peto, R, Rossi, P, Ramsdale, D, Bennett, D, Bray, C, Furse, L

“…All patients suitable for beta blockade entering the coronary care units at Oxford and Manchester were studied in a randomised trial to determine whether administration of intravenous atenolol within 12 hours of chest pain reduced infarct size and ventricular arrythmias. …”