The predictive value of renal vascular resistance for late renal allograft loss. by de Vries, A, van Son, W, van der Heide, J, Ploeg, R, Navis, G, de Jong, P, Gans, R, Bakker, S, Gansevoort, RT

“…The renal artery resistance index (RI), assessed by Doppler ultrasonography, was recently identified as a new risk marker for late renal allograft loss. …”

Malignancies after renal transplantation by Bastiaannet, E, Homan-van der Heide, J, Ploeg, R, Hoekstra, H

ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis. by Mulder, G, Melenhorst, W, Celie, J, Kloosterhuis, N, Hillebrands, J, Ploeg, R, Seelen, M, Visser, L, Dijk, v, van Goor, H

“… BACKGROUND: Interstitial fibrosis and tubular atrophy (IF/TA) is an important cause of renal function loss and ischaemia-reperfusion (I/R) injury is considered to play an important role in its pathophysiology. …”

Brain death induced renal injury. by Westendorp, W, Leuvenink, H, Ploeg, R

“…SUMMARY: In this review, we present an overview of the current knowledge of renal injury induced by pathophysiological effects of brain death and its relevance for renal transplant outcome.The better insight in the role of brain death induced renal injury has clearly demonstrated its detrimental effect on outcome but, also, offers new opportunities for donor management and evaluation of new biomarkers to assess kidney graft quality in the brain dead donor. …”

Predictive capacity of pre-donation GFR and renal reserve capacity for donor renal function after living kidney donation. by Rook, M, Hofker, H, van Son, W, Homan van der Heide, J, Ploeg, R, Navis, G

“…Reliable pre-operative estimation of post-donation renal function is essential. We evaluated the predictive potential of pre-donation glomerular filtration rate (GFR) (iothalamate) and renal reserve capacity for post-donation GFR in kidney donors. …”

Determinants of insulin resistance in renal transplant recipients. by Oterdoom, L, de Vries, A, Gansevoort, RT, van Son, W, van der Heide, J, Ploeg, R, de Jong, P, Gans, R, Bakker, S

“… BACKGROUND: Insulin resistance is considered to play an important role in the development of cardiovascular disease, which limits long-term renal transplant survival. Renal transplant recipients are more insulin-resistant compared with healthy controls. …”

Complement and renal transplantation: from donor to recipient. by Damman, J, Schuurs, T, Ploeg, R, Seelen, M

“…However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. …”

Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation. by Damman, J, Nijboer, W, Schuurs, T, Leuvenink, H, Morariu, A, Tullius, S, van Goor, H, Ploeg, R, Seelen, M

“…The aim of this translational study was to investigate the expression of renal acute phase proteins (APPs) following brain death (BD) and to assess the association with renal allograft outcome after transplantation. …”

Renal function equations before and after living kidney donation: a within-individual comparison of performance at different levels of renal function. by Tent, H, Rook, M, Stevens, L, van Son, W, van Pelt, L, Hofker, H, Ploeg, R, van der Heide, J, Navis, G

“… BACKGROUND AND OBJECTIVES: The Modification of Diet in Renal Disease (MDRD) study equation and the Cockcroft-Gault (CG) equation perform poorly in the (near-) normal range of GFR. …”

OVERWEIGHT-ASSOCIATED HYPERFILTRATION DOES NOT AFFECT RECIPIENT RENAL FUNCTION by Giorgi, M, Tent, H, Rook, M, van Son, W, Hofker, S, Ploeg, R, van der Heide, J, Navis, G

ARA290 Protects Against Renal Ischemia/Reperfusion Injury. by van Rijt, G, Ottens, P, Bos, E, van Goor, H, Ploeg, R, Leuvenink, H

Systemic and Local Renal Complement Activation in Brain-Dead Donors by Damman, J, Leuvenink, H, Nijboer, W, van Oeveren, W, Ploeg, R, Seelen, M

SYSTEMIC AND LOCAL RENAL COMPLEMENT ACTIVATION IN BRAIN-DEAD DONORS by Damman, J, Leuvenink, H, Nijboer, W, van Oeveren, W, Ploeg, R, Seelen, M

ARA290 Protects Against Renal Ischemia/Reperfusion Injury in Pigs by Leuvenink, H, Ottens, P, van Rijt, W, van Goor, H, Ploeg, R

Validation of insulin resistance indexes in a stable renal transplant population. by Oterdoom, L, de Vries, A, van Son, W, van der Heide, J, Ploeg, R, Gansevoort, RT, de Jong, P, Gans, R, Bakker, S

“… OBJECTIVE: The purpose of this study was to investigate the validity of established insulin resistance indexes, based on fasting blood parameters, in a stable renal transplant population. RESEARCH DESIGN AND METHODS: Fasting insulin, homeostasis model assessment (HOMA), the quantitative insulin sensitivity check index (QUICKI), and McAuley's index were assessed for correlation and agreement with whole-body glucose uptake (M value) divided by prevailing serum insulin concentrations (I value) assessed during a hyperinsulinemic-euglycemic clamp in 51 stable renal transplant recipients, who were at a median of 7.5 years after transplant. …”

Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury. by Mulder, G, Nijboer, W, Seelen, M, Sandovici, M, Bos, E, Melenhorst, W, Trzpis, M, Kloosterhuis, N, Visser, L, Henning, R, Leuvenink, H, Ploeg, R, Sunnarborg, S, van Goor, H

“…Furthermore, urinary HB-EGF protein excretion was studied after renal transplantation. Finally, HB-EGF KO and WT mice were subjected to IRI to study the role of HB-EGF in renal injury. …”

Signal transduction pathways involved in brain death-induced renal injury. by Bouma, H, Ploeg, R, Schuurs, T

“…Mitogen-activated protein kinases (MAP-kinases) mediate inflammatory responses and together with NF-kappaB they seem to play an important role in brain death induced renal injury. Altering the activation state of MAP-kinases could be a promising drug target for early intervention to reduce cerebral injury related donor kidney damage and improve outcome after transplantation.…”

ARA290 PROTECTS AGAINST RENAL ISCHEMIA/REPERFUSION INJURY IN PIGS by Leuvenink, H, Ottens, P, van Rijt, W, van Goor, H, Ploeg, R

Withdrawal of cyclosporine after renal transplantation: A brisk pace may be detrimental by Munster, J, Van Son, W, Baauw, M, Ploeg, R, Navis, G, Van der Heide, J, Seelen, MAJ

Renal expression of heat shock proteins after brain death induction in rats. by Bos, E, Schuurs, T, Kraan, M, Ottens, P, van den Eijnden, MM, Leuvenink, H, Kampinga, H, van Goor, H, Ploeg, R

“…No changes were observed in renal HSP27 and HSP40 expression after brain death. …”