Paracetamol and infant immunisation by Ford, K, Pollard, A, Diggle, L, Yu, L

Inappropriate prescribing of promethazine in infants. by Pollard, A, Rylance, G

The influence of maternally derived antibody and infant age at vaccination on infant vaccine responses: an individual participant meta-analysis by Voysey, M, Kelly, D, Fanshawe, T, Sadarangani, M, O'Brien, K, Perera, R, Pollard, A

“…Importance: The design of infant immunization schedules requires an understanding of the factors that determine the immune response to each vaccine antigen. …”

Lymphocyte subpopulations in premature infants: an observational study by Kent, A, Scorrer, T, Pollard, A, Snape, M, Clarke, P, Few, K, Menson, E, Varghese, A, Hughes, S, Ladhani, L, Heath, P

“… <h3>Background and objectives</h3> <p>The infant's immune system evolves over the first months and years of life. …”

Schedules for pneumococcal vaccination of preterm infants: an RCT by Kent, A, Ladhani, S, Andrews, N, Scorrer, T, Pollard, A, Clarke, P, Hughes, S, Heal, C, Menson, E, Chang, J, Satodia, P, Collinson, A, Faust, S, Goldblatt, D, Miller, E, Heath, P, PUNS Study Group

“…BACKGROUND AND OBJECTIVE: Premature infants have a higher risk of invasive pneumococcal disease and are more likely to have lower vaccine responses compared with term infants. …”

Parental views on the introduction of an infant pneumococcal vaccine. by Chantler, T, Newton, S, Lees, A, Diggle, L, Mayon-White, R, Pollard, A, Fitzpatrick, R

“…A heptavalent pneumococcal conjugate vaccine (PnC7) is licensed for use and could prevent the majority of infant invasive pneumococcal infections. A recent announcement confirmed its inclusion into the U.K. childhood immunisation programme. …”

Humoral and cellular immunity to RSV in infants, children and adults by Green, C, Sande, C, De Lara, C, Thompson, A, Silva-Reyes, L, Napolitano, F, Pierantoni, A, Capone, S, Vitelli, A, Klenerman, P, Pollard, A

“…</p> <p><strong>Results</strong> Serum G-specific antibody titres were significantly lower in infants and children than adults. However, serum titres of F-specific and RSV-neutralising antibody and IFNγ-producing T-cell frequencies were low or absent in the infants, but comparable between children and adults. …”

Maternal antibody interference, immunisation schedules, and protective antibody levels in infants by Voysey, M

“…</p> <p>In this thesis I explore the waning of maternal transplacental antibody, its effect on the immunogenicity of infant vaccines, and the timing and spacing of infant doses. …”

Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infants. by Collins, C, Ruggeberg, J, Balfour, G, Tighe, H, Archer, M, Bowen-Morris, J, Diggle, L, Borrow, R, Balmer, P, Buttery, J, Moxon, E, Pollard, A, Heath, P

“…CONCLUSIONS: MCC vaccine is immunogenic and primes for immunologic memory in preterm infants. The decreased memory responses in these preterm infants in conjunction with waning clinical efficacy data for all U.K. infants suggest a role for a routine booster dose of vaccine in all infants receiving MCC, especially those born preterm.…”

Strategies to improve detection and management of human parechovirus infection in young infants by Kadambari, S, Harvala, H, Simmonds, P, Pollard, A, Sadarangani, M

“…These infections are most frequently seen in infants younger than 90 days. Clinical manifestations include encephalitis, meningitis, myocarditis, and sepsis, which can lead to serious neurodevelopmental sequelae in young infants. …”

Four component meningococcal capsular Group B vaccine in preterm infants. by Sadarangani, M, Barlow, S, Anthony, M, Pollard, A

“…Preterm infants are immunized at the same chronological age and same schedule as term infants but have higher rates of post-immunization adverse events (AEs), particularly those infants born at &lt;28 weeks gestation who are hospitalized in the neonatal unit when immunized [3]. …”

An epidemiological study of pneumonia in migrant infants and children on the Thai-Myanmar border by Burgoine, K, Dr Kathy Burgoine

“…Of these 59% were male and half were infants (48%). The median age at presentation was 7.5 months (IQR 3 to 13). …”

Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial by Diggle, L, Deeks, J, Pollard, A

“…Participants: 696 healthy infants vaccinated at 2, 3, and 4 months of age, with follow-up to 5 months of age. …”

Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. by Diggle, L, Deeks, J, Pollard, A

“…PARTICIPANTS: 696 healthy infants vaccinated at 2, 3, and 4 months of age, with follow-up to 5 months of age. …”

Evaluation of haemophilus influenzae type b vaccine for routine immunization in Nepali infants. by Metz, J, Hanieh, S, Pradhan, R, Joshi, A, Shakya, D, Shrestha, L, Shrestha, A, Upadhyay, B, Kelly, S, John, T, Maharjan, B, Yu, L, Omar, O, Borrow, R, Findlow, J, Kelly, D, Thorson, S, Adhikari, N, Murdoch, DR, Pollard, A

“…We determined the immunogenicity of HibCV in Nepali infants, before its introduction into the routine immunization schedule. …”

Immunogenicity and immune memory of a nonadjuvanted quadrivalent meningococcal glycoconjugate vaccine in infants. by Perrett, K, Snape, MD, Ford, K, John, T, Yu, L, Langley, J, McNeil, S, Dull, P, Ceddia, F, Anemona, A, Halperin, SA, Dobson, S, Pollard, A

“…METHODS: One hundred eighty infants (90 in Canada and 90 in the United Kingdom) received 2 doses of MenACWY-CRM at 2 and 4 months of age administered concomitantly with routine infant vaccines. …”

Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency. by Pollard, A, Heale, J, Tsang, A, Massing, B, Speert, D

“…In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins.…”

Production of low-avidity antibody by infants after infection with serogroup B meningococci. by Pollard, A, Levin, M

“…Infants produced specific antibody of lower average avidity than older children--a finding that correlates with absence of serum bactericidal activity in the serum samples of the same infants.…”

Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants by Ruggeberg, J, Collins, C, Clarke, P, Johnson, N, Sinha, R, Everest, N, Chang, J, Stanford, E, Balmer, P, Borrow, R, Martin, S, Robinson, M, Moxon, E, Pollard, A, Heath, P

“…Data on the immunogenicity and memory induction of pneumococcal conjugate vaccines in very preterm infants is limited. We vaccinated 69 full term and 68 preterm infants (median gestational age (GA) 30 weeks) with a 7-valent pneumococcal conjugate vaccine (PCV7) at 2/3/4 months of age, followed by a plain polysaccharide booster at 12 months of age. …”

Outcomes beyond hospital discharge in infants and children with viral meningitis: A systematic review by Hudson, J, Broad, J, Martin, N, Sadarangani, M, Galal, U, Kelly, D, Pollard, A, Kadambari, S

“…A US study of 16 cases demonstrated subtle language difficulties at 3‐year follow‐up in infants in contrast to an Australian study, which revealed no impairment in language. …”