New antimalarials. A risk-benefit analysis. by Nosten, F, Price, R

“…Resistance has already emerged in some parts of the world. Halofantrine is also well tolerated and has a rapid antimalarial activity. …”

Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine. by Brockman, A, Price, R, van Vugt, M, Heppner, D, Walsh, D, Sookto, P, Wimonwattrawatee, T, Looareesuwan, S, White, N, Nosten, F

“…The geometric mean 50% inhibitory concentration (IC50) values from primary infections were: dihydroartemisinin 1.2 ng/mL, artesunate 1.6 ng/mL, artemether 4.8 ng/mL, atovaquone 0.4 ng/mL, lumefantrine 32 ng/mL, chloroquine 149 ng/mL, quinine 354 ng/mL, mefloquine 27 ng/mL and halofantrine 4.1 ng/mL. A significant positive correlation was found between the susceptibility in vitro to artesunate and quinine (r = 0.43, P < 0.001), mefloquine (r = 0.46, P < 0.001), and halofantrine (r = 0.51, P < 0.001). …”

The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. by Price, R, Cassar, C, Brockman, A, Duraisingh, M, van Vugt, M, White, N, Nosten, F, Krishna, S

“…This study assessed genetic polymorphisms in the pfmdr1 gene in 54 parasites collected from the western border of Thailand to determine the relationship of pfmdr1 copy number and codon mutations with parasite sensitivities to mefloquine, chloroquine, halofantrine, quinine, and artesunate assessed in vitro. …”

Effects of artemisinin derivatives on malaria transmissibility. by Price, R, Nosten, F, Luxemburger, C, ter Kuile, F, Paiphun, L, Chongsuphajaisiddhi, T, White, N

“…We compared the following antimalarial drugs in relation to subsequent Plasmodium falciparum gametocyte carriage: mefloquine, halofantrine, quinine, and the artemisinin derivatives. …”