Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda by Xing-Cheng Li, Xing-Cheng Li, Xing-Cheng Li, Yin-Chen Ma, Yin-Chen Ma, Yin-Chen Ma, Jin Long, Jin Long, Jin Long, Xiang Yan, Xiang Yan, Xiang Yan, Nan-Nan Peng, Nan-Nan Peng, Nan-Nan Peng, Cheng-Hui Cai, Cheng-Hui Cai, Cheng-Hui Cai, Wen-Feng Zhong, Wen-Feng Zhong, Wen-Feng Zhong, Yong-Biao Huang, Yong-Biao Huang, Yong-Biao Huang, Xin Qiao, Xin Qiao, Xin Qiao, Li-Xiang Zhou, Li-Xiang Zhou, Li-Xiang Zhou, Qiu-Chen Cai, Qiu-Chen Cai, Qiu-Chen Cai, Chang-Xu Cheng, Chang-Xu Cheng, Chang-Xu Cheng, Gui-Fang Zhou, Gui-Fang Zhou, Gui-Fang Zhou, Yun-Feng Han, Yun-Feng Han, Yun-Feng Han, Hong-Yu Liu, Hong-Yu Liu, Hong-Yu Liu, Qi Zhang, Qi Zhang, Qi Zhang, Hong-Mei Tang, Hong-Mei Tang, Hong-Mei Tang, Jiang-Hui Meng, Jiang-Hui Meng, Jiang-Hui Meng, Kai-Jun Luo, Kai-Jun Luo, Kai-Jun Luo

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Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization by Qi Zhang, Xiaoyan Huang, Ming Chen, Lun Li, Benlong Yang, Jiong Wu, Shenglin Huang, Rong Guo, Zhi-Ming Shao, Bingqiu Xiu, Liyi Zhang, Weiru Chi, Jingyan Xue, Yayun Chi

“…In contrast, LINC00624 inhibited major histocompatibility complex (MHC) class I antigen presentation and limited CD8+T cell infiltration in the cancer microenvironment, resulting in immune checkpoint blockade inhibition and anti-HER2 treatment resistance mediated through ADAR1.Conclusions In summary, these results suggest that LINC00624 is a cancer immunosuppressive lncRNA and targeting LINC00624 through ASOs in tumors expressing high levels of LINC00624 has great therapeutic potential in future clinical applications.…”
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling by Chenlei Zheng, Junli Wang, Yu Zhou, Yi Duan, Rujia Zheng, Yuting Xie, Xiaobao Wei, Jiangchao Wu, Hang Shen, Mao Ye, Bo Kong, Yun-Hua Liu, Pinglong Xu, Qi Zhang, Tingbo Liang

“…Summary: Pancreatic ductal adenocarcinoma (PDAC) features an immunosuppressive tumor microenvironment (TME) that resists immunotherapy. …”
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Current status of xenotransplantation research and the strategies for preventing xenograft rejection by Qiao Zhou, Qiao Zhou, Qiao Zhou, Ting Li, Kaiwen Wang, Qi Zhang, Zhuowen Geng, Shaoping Deng, Shaoping Deng, Shaoping Deng, Chunming Cheng, Yi Wang

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Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Together, this study presents an IL‐1β‐centered immunosuppressive loop between TAMs and tumor cells, highlighting IL‐1β as a candidate therapeutic target to reverse immunosuppression and potentiate immune checkpoint blockade.…”
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The role of angiogenic growth factors in the immune microenvironment of glioma by Zhengmao Ge, Qi Zhang, Wei Lin, Xiaofan Jiang, Yanyu Zhang

“…AGFs were shown to be upregulated in the glioma microenvironment characterized by extensive angiogenesis and high immunosuppression. AGFs produced by tumor and stromal cells can exert an immunomodulatory role in the glioma microenvironment by interacting with immune cells. …”
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Dynamic profiling of immune microenvironment during pancreatic cancer development suggests early intervention and combination strategy of immunotherapy by Jiaqi Yang, Qi Zhang, Junli Wang, Yu Lou, Zhengtao Hong, Shumei Wei, Ke Sun, Jianing Wang, Yiwen Chen, Jianpeng Sheng, Wei Su, Xueli Bai, Tingbo Liang

“…Findings: Two different stages of immunosuppression with unique features were observed in both mouse model and human specimens. …”
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CAA-derived IL-6 induced M2 macrophage polarization by activating STAT3 by Chongru Zhao, Ning Zeng, Xiaomei Zhou, Yufang Tan, Yichen Wang, Jun Zhang, Yiping Wu, Qi Zhang

“…TAMs usually exhibit an M2 phenotype and promote tumor progression by facilitating immunosuppression. This study aimed to investigate the effect of CAA-derived IL-6 on macrophage polarization in promoting BC progression. …”
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Lactate metabolism-related genes to predict the clinical outcome and molecular characteristics of endometrial cancer by Rui Shi, Haojia Li, Sitian Wei, Zhicheng Yu, Jun Zhang, Qi Zhang, Ting Zhou, Yuwei Yao, Qian Zhang, Tangansu Zhang, Hongbo Wang

“…As an abundant metabolite, lactate has been found to play a critical role in cancer development and immunosuppression of TME. However, the potential role of lactate metabolism-related genes in endometrial cancer (EC) remains obscure. …”
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Perfluorocarbon nanodrug induced oxygen self-enriching sonodynamic therapy improves cancer immunotherapy after insufficient radiofrequency ablation by Tongyi Huang, Wenxin Wu, Jiancong Wu, Yang Tan, Minru Zhang, Haiyi Long, Huanling Guo, Xiaoer Zhang, Wenwen Zhou, Qi Zhang, Xiaoyan Xie, Ming Xu, Chunyang Zhang

“…Residual lesions and undetectable metastasis after insufficient radiofrequency ablation (iRFA) are associated with earlier new metastases and poor survival in cancer patients, for induced aggressive tumor phenotype and immunosuppression. Programmed cell death protein 1(PD-1) blockade has been reported to enhance the radiofrequency ablation-elicited antitumor immunity, but its ability to eliminate incompletely ablated residual lesions has been questioned. …”
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Safety and efficacy of radiotherapy/chemoradiotherapy combined with immune checkpoint inhibitors for non-small cell lung cancer: A systematic review and meta-analysis by Jing Wu, Tingting Ni, Rong Deng, Yan Li, Qin Zhong, Fei Tang, Qi Zhang, Chunju Fang, Yingbo Xue, Yan Zha, Yu Zhang, Yu Zhang

“…However, RT is a double-edged sword that not only enhances systemic antitumor immune response, but also promotes immunosuppression to some extent. Nevertheless, many aspects regarding the efficacy and safety of this combination therapy remain unknown. …”
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Recombinant oncolytic adenovirus armed with CCL5, IL-12, and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors by Lin Fang, Sen Yuan, Meng Wang, Chen Zhang, Xueyan Wang, Hailong Li, Jie Yang, Wanjing Li, Nan Sun, Qi Zhang, Yuxin Zhang, Dafei Chai, Huizhong Li, Junnian Zheng, Gang Wang

“…Therefore, OAVs armored with cytokines could be developed as a bioenhancer to defeat the immunosuppressive microenvironment and improve therapeutic efficacy of CAR-T in solid tumors.…”
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Reprogramming of Treg cells in the inflammatory microenvironment during immunotherapy: a literature review by Xinyan Wu, Xinyan Wu, Zhigang Zhou, Qiang Cao, Qiang Cao, Yuquan Chen, Junling Gong, Qi Zhang, Yi Qiang, Yanfeng Lu, Guangzhu Cao

“…This work will provide a foundation for downregulating the immunosuppressive role of Treg in the inflammatory environment in future tumor immunotherapy.…”
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UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer by Jun Xiao, Fei Sun, Ya-Nan Wang, Bo Liu, Peng Zhou, Fa-Xi Wang, Hai-Feng Zhou, Yue Ge, Tian-Tian Yue, Jia-Hui Luo, Chun-Liang Yang, Shan-Jie Rong, Ze-Zhong Xiong, Sheng Ma, Qi Zhang, Yang Xun, Chun-Guang Yang, Yang Luan, Shao-Gang Wang, Cong-Yi Wang, Zhi-Hua Wang

“…Together, our results demonstrate that ablation of UBC9 could reverse the immunosuppressive phenotype of TAMs by promoting STAT4-mediated macrophage activation and macrophage–CD8+ T cell crosstalk, which provides valuable insights to halt the pathogenic process of tumorigenesis.…”
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Upper gastrointestinal tract immune‐related adverse events: Two cases of obstructive complications occurred in immune consolidation therapy after sequential chimeric antigen recept... by Qi Zhang, Chunrui Li, Yang Cao, Na Wang, Liang Huang, Zhen Shang, Jue Wang, Lifang Huang, Jinhuan Xu, Min Xiao, Liting Chen, Xiaojian Zhu, Yicheng Zhang, Yi Xiao

“…During the entire treatment progression for such patients, the correct differential diagnosis of adverse effects and the use of immunosuppressive agents such as glucocorticoids are essential to facilitate early prevention and intervention of irAEs.…”
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TRIM21-mediated Sohlh2 ubiquitination suppresses M2 macrophage polarization and progression of triple-negative breast cancer by Ruihong Zhang, Ying Shen, Qi Zhang, Xiaoning Feng, Xuyue Liu, Xiaoning Huo, Jinhao Sun, Jing Hao

“…Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive activity, and play a pro-tumor role in TNBC lung metastasis. …”
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Establishment of an endoplasmic reticulum stress-related signature predicting outcomes of gastric adenocarcinoma patients by Meiyuan Gong, Jingtao Wang, Wenfang Gao, Qian Liu, Jiaxing Chen, Guojun Wang, Qi Zhang

“…In addition, gene set enrichment and immune infiltration analyses showed that the ER stress-related signature is associated with cancer-related pathway activation and an immunosuppressive tumor microenvironment in GAC.Conclusion: In the current study, we established an ER stress-related signature. …”
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Analysis of Tumor Glycosylation Characteristics and Implications for Immune Checkpoint Inhibitor’s Efficacy for Breast Cancer by Wenchang Lv, Honghao Yu, Mei Han, Yufang Tan, Min Wu, Jun Zhang, Yiping Wu, Qi Zhang

“…Additionally, the Gene Set Enrichment Analysis (GSEA) and immunologic infiltration analysis were adopted and indicated that there was a more immunosuppressive state in the high-risk group than that in the low-risk group. …”
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A dynamic nomogram to predict invasive fungal super-infection during healthcare-associated bacterial infection in intensive care unit patients: an ambispective cohort study in Chin... by Peng Li, Yan Li, Youjian Zhang, Shichao Zhu, Yongju Pei, Qi Zhang, Junping Liu, Junzhe Bao, Mingjie Sun

“…Compared with LASSO-model that included five predictors (combination of priority antimicrobials, immunosuppressant, MDRO, aCCI and S.aureus), the discriminability of stepwise-model was improved by 6.8% after adding two more predictors of COVID-19 and microbiological test before antibiotics use (P<0.01).And the stepwise-model showed similar discriminability in the derivation (the area under curve, AUC=0.87) and external validation cohorts (AUC=0.84, P=0.46). …”
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Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability by Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji

“…Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome these roadblocks have been unsatisfactory. …”
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