Decreased GLUT4 translocation underlies the cardiomyopathy associated with Duchenne muscular dystrophy by Sang, A, Bia, B, Wilding, JR, Radda, G, Davies, K, Clarke, K

PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. by Panagia, M, Gibbons, G, Radda, G, Clarke, K

“…We conclude that elevated plasma free fatty acids are associated with increased injury during ischemia due to decreased cardiac glucose uptake resulting from lower cardiac GLUT-4 protein levels, the levels of GLUT-4 being regulated, probably indirectly, through PPAR-alpha activation.…”

Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart. by Murray, A, Lygate, C, Cole, M, Carr, C, Radda, G, Neubauer, S, Clarke, K

“…Here, we tested whether there is a link between insulin resistance and ischemic damage in the chronically infarcted Wistar rat heart, postulating that the heart would have decreased insulin sensitivity, with lower GLUT4 glucose transporter protein levels due to high circulating free fatty acid (FFA) concentrations. …”

Uncoupling proteins in human heart. by Murray, A, Anderson, R, Watson, G, Radda, G, Clarke, K

“…When plasma free-fatty-acid concentrations were raised, cardiac mitochondrial uncoupling proteins (UCP) increased (isoform UCP2, p<0.0001; isoform UCP3, p=0.0036) and those of glucose transporter (GLUT4) protein decreased (cardiac, p=0.0001; skeletal muscle, p=0.0006). …”

Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart. by Desrois, M, Sidell, R, Gauguier, D, King, L, Radda, G, Clarke, K

“…CONCLUSION: We conclude that decreased insulin receptor beta, IRS-1 and GLUT4 proteins are associated with insulin resistance in type 2 diabetic rat hearts.…”

Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart. by Desrois, M, Sidell, R, Gauguier, D, Davey, C, Radda, G, Clarke, K

“…Glucose transporter (GLUT) 1 protein levels were the same in all hearts, but GLUT4 protein levels were 28% lower (P < 0.01) in all GK rat hearts compared with their sex-matched controls. …”