31P nuclear magnetic resonance in the investigation of renal ischemia during hypotension. by Ratcliffe, P, Moonen, C, Endre, Z, Blackledge, M, Ledingham, J, Radda, G

NUCLEAR MAGNETIC-RESONANCE STUDIES OF RB-87+ TRANSPORT IN PERFUSED RAT-KIDNEY by Endre, Z, Allis, J, Ratcliffe, P, Ledingham, J, Radda, G

A study of patients with alcoholic liver disease by 31P nuclear magnetic resonance spectroscopy. by Angus, P, Dixon, R, Rajagopalan, B, Ryley, N, Simpson, K, Peters, T, Jewell, D, Radda, G

Exercise metabolism in Duchenne muscular dystrophy: a biochemical and [31P]-nuclear magnetic resonance study of mdx mice. by Dunn, J, Tracey, I, Radda, G

INCREASED SENSITIVITY TO RENAL ISCHEMIA DURING HEMORRHAGIC HYPOTENSION DEMONSTRATED IN THE SPONTANEOUSLY HYPERTENSIVE RAT BY P-31 NUCLEAR-MAGNETIC-RESONANCE by Ratcliffe, P, Holloway, P, Moonen, C, Blackledge, M, Ledingham, J, Radda, G

A study of intracellular orthophosphate concentration in human muscle and erythrocytes by 31P nuclear magnetic resonance spectroscopy and selective chemical assay. by Bevington, A, Mundy, K, Yates, A, Kanis, J, Russell, R, Taylor, D, Rajagopalan, B, Radda, G

“…In order to study the relationship between extracellular and intracellular concentrations of orthophosphate (Pi), phosphorus nuclear magnetic resonance spectra were recorded, at rest, from the flexor digitorum superficialis muscle of hypophosphataemic patients with vitamin D-resistant rickets, and patients with Paget's disease of bone before and after they had been made hyperphosphataemic by treatment with the drug ethylidene-1-hydroxy-1,1-bisphosphonate. …”

Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension. by Dudley, C, Taylor, D, Ng, L, Kemp, G, Ratcliffe, P, Radda, G, Ledingham, J

31P nuclear magnetic resonance study of steady-state adenosine 5'-triphosphate levels during graded hypoxia in the isolated perfused rat kidney. by Ratcliffe, P, Endre, Z, Scheinman, S, Tange, J, Ledingham, J, Radda, G

A non-invasive method of measuring concentrations of rubidium in rat skeletal muscle in vivo by 87Rb nuclear magnetic resonance spectroscopy: implications for the measurement of cation transport activity in vivo. by Syme, P, Dixon, R, Allis, J, Aronson, J, Grahame-Smith, D, Radda, G

A mitochondrial encephalomyopathy. A combined 31P magnetic resonance and biochemical investigation. by Hayes, D, Hilton-Jones, D, Arnold, D, Galloway, G, Styles, P, Duncan, J, Radda, G

“…Investigation of her gastrocnemius muscle at rest by phosphorus nuclear magnetic resonance displayed a reduced phosphocreatine concentration with elevated levels of inorganic phosphate and ADP. …”

Plasmodium yoelii: blood oxygen and brain function in the infected mouse. by Krishna, S, Shoubridge, E, White, N, Weatherall, D, Radda, G

“…Despite the severity of terminal infection, the cerebral pH and the relative steady-state concentrations of PCr, ATP and Pi measured in vivo by nuclear magnetic resonance (31P NMR) were normal. Alterations in brain energy status and pH cannot account for cerebral signs or death in this proposed mouse model of cerebral malaria.…”

Acute renal failure in hemorrhagic hypotension: cellular energetics and renal function. by Ratcliffe, P, Moonen, C, Holloway, P, Ledingham, J, Radda, G

“…In male Wistar rats, renal adenosine triphosphate (ATP), inorganic phosphate (Pi) and intracellular pH were measured by 31phosphorus nuclear magnetic resonance (31P NMR) and correlated with renal function before, during, and for one hour after a period of 30 to 40 minutes hemorrhagic hypotension. …”

A 31P-NMR study of muscle exercise metabolism in mdx mice: evidence for abnormal pH regulation. by Dunn, J, Tracey, I, Radda, G

“…We have studied exercise metabolism in vivo in the mdx mouse model of Duchenne muscular dystrophy with 31P-nuclear magnetic resonance spectroscopy. Intracellular pH, ratios of phosphocreatine (PCr) to ATP and PCr to inorganic phosphate (P(i)) expressed as PCr/ATP and PCr/(PCr+P(i)) as well as tension generated at the Achilles tendon were measured during sciatic nerve stimulation. …”

A 31P-NMR study of muscle exercise metabolism in mdx mice: evidence for abnormal pH regulation. by Dunn, J, Tracey, I, Radda, G

“…We have studied exercise metabolism in vivo in the mdx mouse model of Duchenne muscular dystrophy with 31P-nuclear magnetic resonance spectroscopy. Intracellular pH, ratios of phosphocreatine (PCr) to ATP and PCr to inorganic phosphate (P(i)) expressed as PCr/ATP and PCr/(PCr+P(i)) as well as tension generated at the Achilles tendon were measured during sciatic nerve stimulation. …”

Evidence for increased in vivo Na(+)-H+ antiporter activity and an altered skeletal muscle contractile response in the spontaneously hypertensive rat. by Syme, P, Arnolda, L, Green, Y, Aronson, J, Grahame-Smith, D, Radda, G

“…We have assessed the in vivo activity of the Na(+)-H+ antiporter skeletal muscle in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls using phosphorus (31P) nuclear magnetic resonance spectroscopy to measure changes in cytosolic acid concentrations during isometric contraction. …”

Timing of the onset of changes in renal energetics in relation to blood pressure and glomerular filtration in haemorrhagic hypotension in the rat. by Ratcliffe, P, Moonen, C, Ledingham, J, Radda, G

“…The timing and circumstances of changes in renal energetics during the gradual induction of haemorrhagic hypotension were studied in anaesthetised rats by phosphorus-31 nuclear magnetic resonance. Animals were bled at a constant rate of 0.1 ml/min via the femoral artery. …”

An unusual metabolic myopathy: a malate-aspartate shuttle defect. by Hayes, D, Taylor, D, Bore, P, Hilton-Jones, D, Arnold, D, Squier, M, Gent, A, Radda, G

“…Phosphorous nuclear magnetic resonance (NMR) spectroscopy studies of gastrocnemius and flexor digitorum superficialis muscles showed no abnormalities at rest. …”

Evidence for increased in vivo sodium-potassium pump activity and potassium efflux in skeletal muscle of spontaneously hypertensive rats. by Syme, P, Dixon, R, Aronson, J, Grahame-Smith, D, Radda, G

“…We have used 87Rb nuclear magnetic resonance spectroscopy (NMR) to study in vivo rubidium kinetics in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls, using rubidium as a marker for potassium. …”

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. by Scheuermann-Freestone, M, Madsen, P, Manners, D, Blamire, A, Buckingham, R, Styles, P, Radda, G, Neubauer, S, Clarke, K

“…Cardiac high-energy phosphate metabolites were measured at rest using 31P nuclear magnetic resonance spectroscopy (MRS). Skeletal muscle high-energy phosphate metabolites, intracellular pH, and oxygenation were measured using 31P MRS and near infrared spectrophotometry, respectively, before, during, and after exercise. …”

Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart. by Murray, A, Lygate, C, Cole, M, Carr, C, Radda, G, Neubauer, S, Clarke, K

“…Compared with controls, chronically infarcted hearts had 46% lower total glucose uptake and three-fold faster ATP hydrolysis rates, measured using phosphorus-31 nuclear magnetic resonance spectroscopy, during 32-min ischemia at 0.4 ml/min/gww. …”