Effects of smoking on oral cancer transcriptome by Zain, R.B., Karen-Ng, L.P., Cheong, S.C., Anwar, A., Mustaffa, W.M.W., Prepagaran, N., Zaini, Z., Merican, A.F., Abraham, M.T., Tay, K.K., Rahman, Z.A.A., Jallaludin, A.

“…Introduction: Oral cancer is a debilitating disease and the survival rates for these patients have not improved over the past decades. …”
Get full text
Get full text

High throughput mutational profiling of signaling molecules in oral cancer by Zanaruddin, S.N.S., Cheong, S.C., Rahman, Z.A.A., Abd Ghani, W.M.N.W., Mustafa, W.M.W., Zain, R.B., Kong, Y.H., Hor, S.Y., Teo, S.H.

Get full text
Get full text

Dietary pattern and oral cancer risk - a factor analysis study by Helen-Ng, L.C., Razak, I.A., Ghani, W.M.N., Marhazlinda, J., Norain, A.T., Jallaludin, R.L.R., Rahman, Z.A.A., Abdullah, N., Zain, R.B.

“…This study aims to determine the association of dietary patterns with oral cancer risk. Methods A total of 306 matched cases and controls were recruited in this study. …”
Get full text

PD.185 Oral cancer and precancer researchin Malaysia — the database and tissue resource bank by Zain, R.B., Latifah, R.J.R., Razak, I.A., Ismail, S.M., Samsuddin, A.R., Atiya, S.A., Hashim, B.Y., Jallaludin, A., Nasir, W.M., Cheong, S.C., Bustam, A.Z., Mahadzir, W.M.W., Abraham, M.T., Rahman, Z.A.A., Krishnan, G., Kipli, N.P., Norma, J., Tay, K.K., Yuen, K.M., Mocri Team, Members

“…Introduction: Uncoordinated data collection by different research groups prompted the initiation of Malaysian oral cancer Research Initiative (MOCRI) group. Objectives: To coordinate and standardize data and tissue collection and storage, develop a minimum dataset on risk factors, intervention techniques and quality of life of oral cancer patients. …”
Get full text

An oral cancer biobank initiative: a platform for multidisciplinary research in a developing country by Zain, R.B., Athirajan, V., Ghani, W.M.N., Razak, I.A., Raja Latifah, R.J., Ismail, S.M., Sallam, A.A., Bustam, A.Z., Rahman, Z.A.A., Hussien, A., Talib, N., Cheong, S.C., Jallaludin, A.

“…Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. …”
Get full text

Promoting oral cancer awareness and early detection using a mass media approach by Saleh, A., Yang, Y.H., Ghani, W.M.N.W.A., Abdullah, N., Doss, J.G., Navonil, R., Rahman, Z.A.A., Ismail, S.M., Abu Talib, N., Zain, R.B., Cheong, S.C.

“…Background and Aim: Less than 50 of oral cancer cases are diagnosed at early stages of the disease and this is in part due to poor awareness and lack of knowledge on the signs and symptoms of oral cancer. …”
Get full text
Get full text

An oral cancer biobank initiative: a platform for multidisciplinary research in a developing country by Zain, R.B., Athirajan, V., Ghani, W.M.N., Razak, I.A., Latifah, R.J.R., Ismail, S.M., Sallam, A.A., Bustam, A.Z., Rahman, Z.A.A., Hussien, A., Talib, N., Cheong, S.C., Jallaludin, A.

“…Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. …”
Get full text
Get full text

Selected transcriptome profiles of oral cancer suggestive of field cancerisation using second generation sequencing by Zain, R.B., Anwar, A., Karen-Ng, L.P., Cheong, S.C., Zaini, Z., Prepagaran, N., Hercus, R., Idris, N.M., Saidin, A., Chia, J.Y., Merican, A.F., Abraham, M.T., Tay, K.K., Mustaffa, W.M.W., Norain, A.T., Rahman, Z.A.A., Jallaludin, A.

“…Objectives: To characterize differential gene expression between oral cancerous tissues and the normal mucosal tissues of oral cancer patients and oral mucosal tissues of cancer free patients using second generation sequencing. …”
Get full text

High serum level of retinol and alpha-Tocopherol affords protection against oral cancer in a multiethnic population by Athirajan, V., Razak, I.A., Thurairajah, N., Ghani, W.M.N., Ching, H.N.L., Yi, H.Y., Peng, K.N.L., Rahman, Z.A.A., Mustafa, W.M.W., Abraham, M.T., Kiong, T.K., Mun, Y.K., Jalil, N., Zain, R.B.

“…Background: A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, alpha-tocopherol and beta-carotene with the risk of oral cancer. …”
Get full text

Aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase M1 (GSTM1) polymorphisms in relation to oral cancer risk among Malaysians by Karen-Ng, L.P., Ghani, W.M.N., Vimmitra, A., Yuen, K.M., Tan, H.S., Lim, S.J., Abraham, M.T., Rahman, Z.A.A., Tay, K.K., Mustafa, W.M.W., Jalil, N., Norlida, A., Cheong, S.C., Zain, R.B.

“…This study aims to determine ALDH2 and GSTM1 polymorphisms and its association with oral cancer risk. Method: An unmatched case-control study was conducted using 163 oral cancer patients and 87 non-cancer subjects selected from the OCRCC database. …”
Get full text
Get full text

Combined effects of isothiocyanates (ITCs) intake, glutathione S-transferases (GSTs) polymorphism and risk habits on oral squamous cell carcinoma (OSCC) associated with earlier age... by Karen-Ng, L.P., Marhazlinda, J., Rahman, Z.A.A., Abraham, M.T., Cheong, S.C., Zain, R.B.

“…This study suggests that combinatory effects between dietary ITCs, GSTP1 polymorphism and risk habits may be associated with risk of oral cancer and modulate the age of disease onset.…”
Get full text
Get full text

Histopathologic findings and assessment of cervical lymph node metastasis in oral squamous cell carcinoma of Malaysian patients by Ismail, S.B., Zain, R.B., Kipli, N.P., Abraham, T., Ismail, M.S., Rahman, Z.A.A., Prepageran, N., Jalaludin, M.A.B.

“…Where there is no neck resection, the clinical nodal status was obtained from the Oral Cancer database maintained at the University of Malaya Oral Cancer Research and Coordinating Centre (UM-OCRCC) while the histopathologic data were obtained from examination of the resected specimens of patients whose records were extracted from the UM-OCRCC. …”
Get full text

Genome wide profiling of tongue and cheek cancer using high resolution array based CGH by Vincent-Chong, V.K., Rahman, Z.A.A., Zakaria, Z., Tay, K.K., Ismail, S.M., Zain, R.B.

“…In order to understand these behaviors, there is a need to look into the chromosomal alterations and gene pathways that maybe associated with oral cancer at these sites. Therefore, the objective of this study is to determine the differences in chromosomal aberrations and gene pathways involved in tongue and cheek cancer using high resolution array CGH. …”
Get full text
Get full text

Oral mucosal lesions in Indigenous people of Sarawak and their related habits by Rahman, Z.A.A., Zain, R.B., Abang, Z., Ikeda, N., Razak, I.A., Fukano, H., Abdullah, F., Hii, M.

“…The Malaysian nationwide survey on oral mucosal lesions (OML) in 1993/94 showed a low prevalence of OML in particular oral cancer and precancer (OPC) among the Malays as compared to the Indians and the Indigenous people of Sabah and Sarawak. …”
Get full text

Oral mucosal lesions in Malay quid and non-quid chewers in Kelantan by Raman, R.A., Rahman, Z.A.A., Zain, R.B., Samsuddin, A.R., Razak, I.A., Abdullah, F., Venugopal, I.

“…The Malaysian nationwide survey on oral mucosal lesions (OML) in 1993/94 showed a low prevalence of OML in particular oral cancer and precancer (OPC) among Malays as compared to the Indians and the Indigenous people of Sabah and Sarawak. …”
Get full text

Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9 by Vincent-Chong, V.K., Anwar, A., Karen-Ng, L.P., Cheong, S.C., Yang, Y.H., Pradeep, P.J., Rahman, Z.A.A., Ismail, S.M., Zaini, Z.M., Prepageran, N., Kallarakkal, T.G., Ramanathan, A., Mohayadi, N.A.B.M, Rosli, N.S.B.M., Mustafa, W.M.W., Abraham, M.T., Tay, K.K., Zain, R.B.

“…A major drawback in diagnosis and treatment of OSCC is the lack of knowledge relating to how genetic instability in oral cancer genomes affects oral carcinogenesis. Hence, the key aim of this study was to identify copy number alterations (CNAs) that may be cancer associated in OSCC using high-resolution array comparative genomic hybridization (aCGH). …”
Get full text