Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods by Rebecca Chamberlain, Hellen Windolf, Simon Geissler, Julian Quodbach, Jörg Breitkreutz

“…The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole for the treatment of Parkinson’s disease. …”
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3D Printed Mini-Floating-Polypill for Parkinson’s Disease: Combination of Levodopa, Benserazide, and Pramipexole in Various Dosing for Personalized Therapy by Hellen Windolf, Rebecca Chamberlain, Jörg Breitkreutz, Julian Quodbach

“…As the disease progresses, therapy must be supplemented with a dopamine agonist (e.g., pramipexole (PDM)). Side effects increase, as do the required dose and dosing intervals. …”
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Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous Quantification of Differently Dosed Active Ingredients during Drug Release by Rebecca Chamberlain, Hellen Windolf, Bjoern B. Burckhardt, Jörg Breitkreutz, Björn Fischer

“…This allowed the low-concentration of pramipexole and the higher concentrations of levodopa and benserazide occurring during drug release to be determined in a single chromatographic run within 22.5 min.…”
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Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of Tablet Geometry by Hellen Windolf, Rebecca Chamberlain, Julian Quodbach

“…Three drug substances were used: pramipexole, levodopa (both BCS I) and praziquantel (BCS II). …”
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