Comparative Evaluation of Quetiapine Plus Lamotrigine Versus Quetiapine Monotherapy in Bipolar Depression: A Randomized Placebo Controlled Trial (CEQUEL) by Geddes, J, Hinds, C, Rendell, J, Gardiner, A, Voysey, M, Attenburrow, M, Goodwin, G

Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial. by Geddes, J, Gardiner, A, Rendell, J, Voysey, M, Tunbridge, E, Hinds, C, Yu, L, Hainsworth, J, Attenburrow, M, Simon, J, Goodwin, G, Harrison, P

“…The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. …”

CEQUEL: A Comparative Evaluation of QUEtiapine-Lamotrigine combination versus quetiapine monotherapy, (and folic acid versus placebo) in people with bipolar depression: a 2x2 factorial randomised trial by Gardiner, A, Rendell, J, Stephens, W, Hainsworth, J, Yu, L, Brown, S, Goodwin, G, Geddes, J

Comparative efficacy and acceptability of antimanic drugs in acute mania: A multiple-treatments meta-analysis by Cipriani, A, Barbui, C, Salanti, G, Rendell, J, Brown, R, Stockton, S, Purgato, M, Spineli, L, Goodwin, G, Geddes, J

“…Olanzapine, risperidone, and quetiapine led to significantly fewer discontinuations than did lithium, lamotrigine, placebo, topiramate, and gabapentin. …”

Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. by Cipriani, A, Barbui, C, Salanti, G, Rendell, J, Brown, R, Stockton, S, Purgato, M, Spineli, L, Goodwin, G, Geddes, J

“…Olanzapine, risperidone, and quetiapine led to significantly fewer discontinuations than did lithium, lamotrigine, placebo, topiramate, and gabapentin. …”

Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial by Tunbridge, E, Attenburrow, M, Gardiner, A, Rendell, J, Hinds, C, Goodwin, G, Harrison, P, Geddes, J

“…<p><strong>Objectives</strong> CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double‐blind, randomized, placebo‐controlled, parallel group, 2×2 factorial trial that examined the effect of adding lamotrigine and/or folic acid (FA) to quetiapine in bipolar depression. …”

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder by Cipriani, A, Barbui, C, Rendell, J, Geddes, J

“…Results: Six placebo-controlled trials comparing aripiprazole, olanzapine, quetiapine and ziprasidone were found in the FDA website. …”

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder. by Cipriani, A, Barbui, C, Rendell, J, Geddes, J

“…RESULTS: Six placebo-controlled trials comparing aripiprazole, olanzapine, quetiapine and ziprasidone were found in the FDA website. …”