e-Cigarette Use and the Cessation of Tobacco Cigarette Smoking: Protocol for an Umbrella Review by Renee O'Leary, Riccardo Polosa

“…In the past 2 years, a dozen or more systematic reviews on ENDS and cigarette smoking cessation have been published that present differing conclusions and recommendations on the use of ENDS. …”
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Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project by Rosalia Emma, Virginia Fuochi, Alfio Distefano, Konstantinos Partsinevelos, Sonja Rust, Fahad Zadjali, Mohammed Al Tobi, Razan Zadjali, Zaina Alharthi, Roberta Pulvirenti, Pio Maria Furneri, Riccardo Polosa, Ang Sun, Massimo Caruso, Giovanni Li Volti, the Replica Project Group

“…As in the original paper, we performed Neutral Red Uptake (NRU) assay for the evaluation of cytotoxicity, Ames test for the evaluation of mutagenesis and In Vitro Micronuclei (IVMN) assay for the evaluation of genotoxicity on cells treated with cigarette smoke or e-cigarette aerosol. The results showed high cytotoxicity, mutagenicity and genotoxicity induced by cigarette smoke, but slight or no cytotoxic, mutagenic and genotoxic effects induced by the e-cigarette aerosol. …”
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Protocol for the “magnitude of cigarette substitution after initiation of e-cigarettes and its impact on biomarkers of exposure and potential harm in dual users” (MAGNIFICAT) study... by Riccardo Polosa, Riccardo Polosa, Riccardo Polosa, Nikola Pluym, Max Scherer, Jonathan Belsey, Christopher Russell, Pasquale Caponnetto, Pasquale Caponnetto, Jakub Weglarz, Davide Campagna, Davide Campagna

Subjects: “…cigarette and e-cigarette smoking…”
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Identifying spin bias of nonsignificant findings in biomedical studies by Renée O’Leary, Giusy Rita Maria La Rosa, Robin Vernooij, Riccardo Polosa

“…Abstract Objective The purpose of this research note is to share a technique for the identification of spin bias that we developed as part of a living systematic review on the cardiovascular testing of e-cigarette substitution for cigarette smoking. While some researchers have remarked on the subjective nature of ascertaining spin bias, our technique objectively documents forms of spin bias arising from the misrepresentation of nonsignificant findings and from the omission of data. …”
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Modeling Aerial Transmission of Pathogens (Including the SARS-CoV-2 Virus) through Aerosol Emissions from E-Cigarettes by Roberto A. Sussman, Eliana Golberstein, Riccardo Polosa

“…Given the lack of empiric evidence on this phenomenon, we consider available evidence on cigarette smoking and respiratory droplet emission from mouth breathing through a mouthpiece as convenient proxies to infer the capacity of vaping to transport pathogens in respiratory droplets. …”
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Smoking Addiction in Patients with Schizophrenia Spectrum Disorders and Its Perception and Intervention in Healthcare Personnel Assigned to Psycho-Rehabilitation Programs: A Qualit... by Pasquale Caponnetto, Marilena Maglia, Marta Mangione, Chiara Vergopia, Graziella Chiara Prezzavento, Riccardo Polosa, Maria Catena Quattropani, Jennifer DiPiazza, Maria Salvina Signorelli

“…The point of view of health personnel (Psychologists, Psychiatrists, Pedagogists, and Nurses) about cigarette smoking in these patients was analyzed, focusing on their implications in disturbance and comparing them with e-cigarettes too. …”
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A Global Health Survey of People Who Vape but Never Smoked: Protocol for the VERITAS (Vaping Effects: Real-World International Surveillance) Study by Jeffrey Zamora Goicoechea, Allison Boughner, Juan José Cirion Lee, Aman Mahajan, Kurt Yeo, Maris Sproga, Tasmin Patel, Claudio Saitta, Christopher Russell, Michael Coughlan, Pasquale Caponnetto, Riccardo Polosa

“…Large prospective studies of well-characterized electronic cigarette users with and without a history of combustible cigarette smoking are warranted to establish the long-term effects of regular vaping on respiratory health. …”
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Changes in Oral Health and Dental Esthetic in Smokers Switching to Combustion-Free Nicotine Alternatives: Protocol for a Multicenter and Prospective Randomized Controlled Trial by Gianluca Conte, Sebastiano Antonio Pacino, Salvatore Urso, Doris Greiling, Pasquale Caponnetto, Eugenio Pedullà, Luigi Generali, Ugo Consolo, Vittorio Checchi, Stefan Gospodaru, Gheorghe Bordeniuc, Valeriu Fala, Jan Kowalski, Maciej Nowak, Renata Górska, Amaliya Amaliya, Iain Chapple, Michael Milward, Robert Maclure, Gianna Maria Nardi, Riccardo Polosa

“…ConclusionsThis will be the first study to provide key insights into oral health benefits or risks associated with using C-F NA in smokers who are seeking alternatives to cigarette smoking. Trial RegistrationClinicalTrials.gov NCT04649645; https://clinicaltrials.gov/ct2/show/NCT04649645 International Registered Report Identifier (IRRID)DERR1-10.2196/53222…”
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E-cigarettes and heated tobacco products impact on dental color parameters by Shipra Gupta, Vaibhav Sahni, Rosalia Emma, Stefan Gospodaru, Gheorghe Bordeniuc, Valeriu Fala, Amaliya Amaliya, Giusy Rita Maria La Rosa, Sebastiano Antonio Pacino, Salvatore Urso, Hasan Guney Yilmaz, Giovanni Zucchelli, Riccardo Polosa

“…Compared with conventional cigarettes, E-cigarettes (ECs) and heated tobacco products (HTPs) may offer substantial reduction in exposure to pigmented tar-like compounds of cigarette smoke. It is possible that improvements in dental color indices may be observed in those who have stopped smoking combustible cigarettes by switching to tar-free nicotine delivery products. …”
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