Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort by Fortner, RT, Sarink, D, Schock, H, Johnson, T, Tjønneland, A, Olsen, A, Overvad, K, Affret, A, His, M, Boutron-Ruault, MC, Boeing, H, Trichopoulou, A, Naska, A, Orfanos, P, Palli, D, Sieri, S, Mattiello, A, Tumino, R, Ricceri, F, Bueno-de-Mesquita, HB, Peeters, PH, Van Gils, CH, Weiderpass, E, Lund, E, Quirós, JR, Agudo, A, Sánchez, MJ, Chirlaque, MD, Ardanaz, E, Dorronsoro, M, Key, T, Khaw, KT, Rinaldi, S, Dossus, L, Gunter, M, Merritt, MA, Riboli, E, Kaaks, R

“…Circulating OPG and breast cancer risk has been examined in only one prior study.A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. by James, R, Lukanova, A, Dossus, L, Becker, S, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Engel, P, Clavel-Chapelon, F, Chang-Claude, J, Vrieling, A, Boeing, H, Schütze, M, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Rodríguez, L, Buckland, G

“…In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. …”

Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Travis, R, Crowe, F, Allen, N, Appleby, P, Roddam, A, Tjønneland, A, Olsen, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Dilis, V, Trichopoulos, D, Vineis, P, Palli, D, Tumino, R, Sieri, S, Bueno-de-Mesquita, H, van Duijnhoven, F, Chirlaque, MD, Barricarte, A, Larrañaga, N, González, C, Argüelles, M, Sánchez, M, Stattin, P, Hallmans, G, Khaw, K, Bingham, S, Rinaldi, S, Slimani, N, Jenab, M, Riboli, E, Key, T

“…The authors examined whether vitamin D concentrations were associated with prostate cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (1994-2000). …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Harewood, R, Rothwell, JA, Bešević, J, Viallon, V, Achaintre, D, Gicquiau, A, Rinaldi, S, Wedekind, R, Prehn, C, Adamski, J, Schmidt, JA, Jacobs, I, Tjønneland, A, Olsen, A, Severi, G, Kaaks, R, Katzke, V, Schulze, MB, Prada, M, Masala, G, Agnoli, C, Panico, S, Sacerdote, C, Jakszyn, PG, Sánchez, M-J, Castilla, J, Chirlaque, M-D, Atxega, AA, van Guelpen, B, Heath, AK, Papier, K, Tong, TYN, Summers, SA, Playdon, M, Cross, AJ, Keski-Rahkonen, P, Chajès, V, Murphy, N, Gunter, MJ

“…</p> <p><strong>Methods:</strong>&nbsp;In a case&ndash;control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. …”

Soluble receptor for advanced glycation end-products (sRAGE) and colorectal cancer risk: a case–control study nested within a European prospective cohort by Aglago, EK, Rinaldi, S, Freisling, H, Jiao, L, Hughes, DJ, Fedirko, V, Schalkwijk, CG, Weiderpass, E, Dahm, CC, Overvad, K, Eriksen, AK, Kyrø, C, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Katzke, V, Kühn, T, Schulze, MB, Aleksandrova, K, Masala, G, Krogh, V, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, B, van Gils, CH, Sandanger, TM, Gram, IT, Skeie, G, Quirós, JR, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Ardanaz, E, Johansson, I, Harlid, S, Perez-Cornago, A, Mayén, A-L, Cordova, R, Gunter, MJ, Vineis, P, Cross, AJ, Riboli, E, Jenab, M

“…</p> <p><strong>Methods:</strong> To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Dossus, L, McKay, J, Canzian, F, Wilkening, S, Rinaldi, S, Biessy, C, Olsen, A, Tjønneland, A, Jakobsen, M, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fournier, A, Linseisen, J, Lukanova, A, Boeing, H, Fisher, E, Trichopoulou, A, Georgila, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Quirós, JR

“…We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. …”

Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition. by Travis, R, Key, T, Allen, N, Appleby, P, Roddam, A, Rinaldi, S, Egevad, L, Gann, P, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjønneland, A, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Sieri, S, Vineis, P, Palli, D, Quirós, JR, Ardanaz, E

“…We examined the hypothesis that serum concentrations of circulating androgens and sex hormone binding globulin (SHBG) are associated with risk for prostate cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: Results from the European prospective investigation into cancer and nutr... by Allen, N, Key, T, Appleby, P, Travis, R, Roddam, A, Rinaldi, S, Egevad, L, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjonneland, A, Gronbaek, H, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Berrino, F, Mattiello, A, Sacerdote, C, Palli, D, Quiros, JR

“…Methods: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutr... by Allen, N, Key, T, Appleby, P, Travis, R, Roddam, A, Rinaldi, S, Egevad, L, Rohrmann, S, Linseisen, J, Pischon, T, Boeing, H, Johnsen, N, Tjønneland, A, Grønbaek, H, Overvad, K, Kiemeney, L, Bueno-de-Mesquita, H, Bingham, S, Khaw, K, Tumino, R, Berrino, F, Mattiello, A, Sacerdote, C, Palli, D, Quirós, JR

“…METHODS: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. …”

Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk. by McSorley, M, Alberg, A, Allen, D, Allen, N, Brinton, L, Dorgan, J, Kaaks, R, Rinaldi, S, Helzlsouer, K

“…The aim of this study was to determine the association between prediagnostic levels of follicle stimulating hormone (FSH) and subsequent development of invasive epithelial ovarian cancer. A nested case-control study was conducted using cases and controls drawn from three cohorts: CLUE I and CLUE II of Washington County, MD, and the Island of Guernsey Study, United Kingdom. …”

Blood metabolic signatures of body mass index: a targeted metabolomics study in the EPIC Cohort by Carayol, M, Leitzmann, MF, Ferrari, P, Zamora-Ros, R, Achaintre, D, Stepien, M, Schmidt, JA, Travis, RC, Overvad, K, Tjønneland, A, Hansen, L, Kaaks, R, Kühn, T, Boeing, H, Bachlechner, U, Trichopoulou, A, Bamia, C, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Quirós, JR, Sánchez-Cantalejo, E, Huerta, JM, Ardanaz, E, Arriola, L, Agudo, A, Nilsson, J, Melander, O, Bueno-de-Mesquita, B, Peeters, PH, Wareham, N, Khaw, KT, Jenab, M, Key, TJ, Scalbert, A, Rinaldi, S

“…Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). …”

Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts by Jung, S, Allen, N, Arslan, AA, Baglietto, L, Barricarte, A, Brinton, LA, Egleston, BL, Falk, RT, Fortner, RT, Helzlsouer, KJ, Gao, Y, Idahl, A, Kaaks, R, Krogh, V, Merritt, MA, Lundin, E, Onland-Moret, NC, Rinaldi, S, Schock, H, Shu, X-O, Sluss, PM, Staats, PN, Sacerdote, C, Travis, RC, Tjønneland, A, Trichopoulou, A, Tworoger, SS, Visvanathan, K, Weiderpass, E, Zeleniuch-Jacquotte, A, Dorgan, JF

“…However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. …”

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk by Campa, D, Hüsing, A, McKay, J, Sinilnikova, O, Vogel, U, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, N, Gils, V, Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Quirós, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, R, Key, T, Wareham, N, Khaw, K, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R, Canzian, F

“…<br/><br/> <b>Methods:</b> we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.…”

Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: A cross-sectional study within the EPIC cohort by Rinaldi, S, Kaaks, R, Friedenreich, C, Key, T, Travis, R, Biessy, C, Slimani, N, Overvad, K, Østergaard, J, Tjønneland, A, Olsen, A, Mesrine, S, Fournier, A, Dossus, L, Lukanova, A, Johnson, T, Boeing, H, Vigl, M, Trichopoulou, A, Benetou, V, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F

“…Methods: A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women included as controls in case-control studies on endogenous hormones (steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth factors) levels, and cancer risk nested within European Prospective Investigation into Cancer and Nutrition cohort was performed. …”

Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium by Ose, J, Poole, E, Schock, H, Lehtinen, M, Arslan, A, Zeleniuch-Jacquotte, A, Visvanathan, K, Helzlsouer, K, Buring, J, Lee, I, Tjønneland, A, Dossus, L, Trichopoulou, A, Masala, G, Onland-Moret, N, Weiderpass, E, Duell, E, Idahl, A, Travis, R, Rinaldi, S, Merritt, M, Trabert, B, Wentzensen, N, Tworoger, S, Kaaks, R, Fortner, R

“…We conducted a pooled analysis of 7 nested case-control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens (testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)), sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e. histology, grade, and stage). …”

Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC... by Canzian, F, McKay, J, Cleveland, R, Dossus, L, Biessy, C, Rinaldi, S, Landi, S, Boillot, C, Monnier, S, Chajès, V, Clavel-Chapelon, F, Téhard, B, Chang-Claude, J, Linseisen, J, Lahmann, P, Pischon, T, Trichopoulos, D, Trichopoulou, A, Zilis, D, Palli, D, Tumino, R, Vineis, P, Berrino, F, Bueno-de-Mesquita, H, Gils, v

“…We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. …”

Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition. by Schmidt, J, Allen, N, Almquist, M, Franceschi, S, Rinaldi, S, Tipper, S, Tsilidis, K, Weiderpass, E, Overvad, K, Tjønneland, A, Boutron-Ruault, M, Dossus, L, Mesrine, S, Kaaks, R, Lukanova, A, Boeing, H, Lagiou, P, Trichopoulos, D, Trichopoulou, A, Palli, D, Krogh, V, Panico, S, Tumino, R, Zanetti, R, Bueno-de-Mesquita, H

“…METHODS: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. …”

Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. by Rohrmann, S, Grote, V, Becker, S, Rinaldi, S, Tjønneland, A, Roswall, N, Grønbæk, H, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Teucher, B, Boeing, H, Drogan, D, Dilis, V, Lagiou, P, Trichopoulou, A, Palli, D, Tagliabue, G, Tumino, R, Vineis, P, Mattiello, A, Rodríguez, L, Duell, E, Molina-Montes, E

“…Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. …”

Endometrial cancer risk prediction including serum-based biomarkers: Results from the EPIC cohort by Fortner, R, Hüsing, A, Kühn, T, Konar, M, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Severi, G, Fournier, A, Boeing, H, Trichopoulou, A, Benetou, V, Orfanos, P, Masala, G, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H, Peeters, P, Weiderpass, E, Gram, I, Gavrilyuk, O, Quirós, J, Huerta, J, Ardanaz, E, Larrañaga, N, Lujan-Barroso, L, Sánchez-Cantalejo, E, Butt, S, Borgquist, S, Idahl, A, Lundin, E, Khaw, K, Allen, N, Rinaldi, S, Dossus, L, Gunter, M, Merritt, M, Tzoulaki, I, Riboli, E, Kaaks, R

“…Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. …”