The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. by Müller, P, Schulz, R, Maretto, S, Costello, I, Srinivas, S, Bikoff, E, Robertson, E

BMP4 substitutes for loss of BMP7 during kidney development. by Oxburgh, L, Dudley, A, Godin, R, Koonce, C, Islam, A, Anderson, D, Bikoff, E, Robertson, E

“…BMP4-deficient embryos display mesodermal patterning defects at early post-implantation stages, whereas loss of BMP7 selectively disrupts kidney and eye morphogenesis. Whether these distinct phenotypes simply reflect differences in expression domains, or alternatively intrinsic differences in the signaling properties of these ligands remains unknown. …”

The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development by I. Ahmed, M, Elias, S, Mould, A, Bikoff, E, Robertson, E

“…Mammary gland morphogenesis depends on a tight balance between cell proliferation, differentiation and apoptosis, to create a defined functional hierarchy within the epithelia. …”

Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy by Nelson, A, Mould, A, Bikoff, E, Robertson, E

“…Our experiments provide new insights into the functionally distinct cell types present at the maternal-foetal interface and advance our knowledge of dynamic gene expression patterns controlling placental morphogenesis and vascular mimicry.…”

Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. by Mould, A, Morgan, M, Li, L, Bikoff, E, Robertson, E

“…In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TGCs and defines a lineage-restricted progenitor cell population contributing to placental growth and morphogenesis.…”

Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life by Elias, S, Morgan, M, Bikoff, E, Robertson, E

“…The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly understood. …”

Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. by Maretto, S, Müller, P, Aricescu, A, Cho, K, Bikoff, E, Robertson, E

“…Collectively these experiments demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo.…”

The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. by Vincent, S, Dunn, N, Sciammas, R, Shapiro-Shalef, M, Davis, M, Calame, K, Bikoff, E, Robertson, E

“…Rather, loss of Blimp1 expression disrupts morphogenesis of the caudal branchial arches and leads to a failure to correctly elaborate the labyrinthine layer of the placenta. …”

Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. by Arnold, S, Maretto, S, Islam, A, Bikoff, E, Robertson, E

“…Thus, as for Smad1 and Smad5 mutant embryos, Smad1+/-:Smad5+/- double heterozygotes die by E10.5 and display defects in allantois morphogenesis, cardiac looping and primordial germ cell (PGC) specification. …”

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. by Prall, O, Menon, M, Solloway, M, Watanabe, Y, Zaffran, S, Bajolle, F, Biben, C, McBride, J, Robertson, B, Chaulet, H, Stennard, F, Wise, N, Schaft, D, Wolstein, O, Furtado, M, Shiratori, H, Chien, K, Hamada, H, Black, B, Saga, Y, Robertson, E, Buckingham, M, Harvey, R

“…Our findings demonstrate that Nkx2-5 orchestrates the transition between periods of cardiac induction, progenitor proliferation, and OFT morphogenesis via a Smad1-dependent negative feedback loop, which may be a frequent molecular target in CHD.…”

Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species. by Adams, D, Karolak, M, Robertson, E, Oxburgh, L

“…Bmp7 is expressed in numerous tissues throughout development and is required for morphogenesis of the eye, hindlimb and kidney. In this study we show that the majority if not all of the cis-regulatory sequence governing expression at these anatomical sites during development is present in approximately 20 kb surrounding exon 1. …”

The roles of Flrt2 and Flrt3 cell surface proteins during mouse development by Salman, A

“…<p>Embryos morphogenesis relies on the interactions between different tissues and their constituent cells. …”