Resistance to the mTOR Inhibitor Temsirolimus Alters Adhesion and Migration Behavior of Renal Cell Carcinoma Cells through an Integrin α5– and Integrin β3–Dependent Mechanism by Eva Juengel, Jasmina Makarević, Michael Reiter, Jens Mani, Igor Tsaur, Georg Bartsch, Axel Haferkamp, Roman A. Blaheta

“…The physiological relevance of the integrins was then determined by blocking studies and small interfering RNA knockdown. …”
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CXCR4 Chemokine Receptor Mediates Prostate Tumor Cell Adhesion through α5 and β3 Integrins by Tobias Engl, Boma Relja, Dana Marian, Christa Blumenberg, Iris Müller, Wolf-Dietrich Beecken, Jon Jones, Eva M. Ringel, Jürgen Bereiter-Hahn, Dietger Jonas, Roman A. Blaheta

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Integrin α2 and β1 Cross-Communication with mTOR/AKT and the CDK-Cyclin Axis in Hepatocellular Carcinoma Cells by Mazen A. Juratli, He Zhou, Elsie Oppermann, Wolf O. Bechstein, Andreas Pascher, Felix K.-H. Chun, Eva Juengel, Jochen Rutz, Roman A. Blaheta

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Insulin-like Growth Factor-1 Influences Prostate Cancer Cell Growth and Invasion through an Integrin α3, α5, αV, and β1 Dependent Mechanism by Carolin Siech, Jochen Rutz, Sebastian Maxeiner, Timothy Grein, Marlon Sonnenburg, Igor Tsaur, Felix K.-H. Chun, Roman A. Blaheta

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Bladder Cancer Metastasis Induced by Chronic Everolimus Application Can Be Counteracted by Sulforaphane In Vitro by Saira Justin, Jochen Rutz, Sebastian Maxeiner, Felix K.-H. Chun, Eva Juengel, Roman A. Blaheta

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Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro by Hui Xie, Jochen Rutz, Sebastian Maxeiner, Timothy Grein, Anita Thomas, Eva Juengel, Felix K.-H. Chun, Jindrich Cinatl, Axel Haferkamp, Igor Tsaur, Roman A. Blaheta

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HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression by Jasmina Makarević, Jochen Rutz, Eva Juengel, Sebastian Maxeiner, Jens Mani, Stefan Vallo, Igor Tsaur, Frederik Roos, Felix K.-H. Chun, Roman A. Blaheta

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Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carcinoma Metastatic Behavior in Vitros by Jochen Rutz, Sebastian Maxeiner, Saira Justin, Beatrice Bachmeier, August Bernd, Stefan Kippenberger, Nadja Zöller, Felix K.-H. Chun, Roman A. Blaheta

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Mechanisms behind Temsirolimus Resistance Causing Reactivated Growth and Invasive Behavior of Bladder Cancer Cells In Vitro by Eva Juengel, Iyad Natsheh, Ramin Najafi, Jochen Rutz, Igor Tsaur, Axel Haferkamp, Felix K.-H. Chun, Roman A. Blaheta

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Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation by Eva Juengel, Jochen Rutz, Moritz Meiborg, Sascha D. Markowitsch, Sebastian Maxeiner, Timothy Grein, Anita Thomas, Felix K.-H. Chun, Axel Haferkamp, Igor Tsaur, Olesya Vakhrusheva, Roman A. Blaheta

“…Alterations in CD44 expression were not homogeneous but rather depended on the extract and the cell line. Integrin α3 was, likewise, differently modified. Integrin α5 was diminished in RT112 and UMUC3 cells (significantly) and TCCSup (trend) by <i>Populi</i> and <i>Salicis</i>. …”
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Amygdalin Exerts Antitumor Activity in Taxane-Resistant Prostate Cancer Cells by Igor Tsaur, Anita Thomas, Michelle Monecke, Marion Zugelder, Jochen Rutz, Timothy Grein, Sebastian Maxeiner, Hui Xie, Felix K.-H. Chun, Florian Rothweiler, Jindrich Cinatl, Martin Michaelis, Axel Haferkamp, Roman A. Blaheta

“…A moderate influence of amygdalin on tumor cell adhesion and chemotaxis was observed as well, paralleled by modifications of cytoskeletal proteins and the integrin β1 expression level. Amygdalin may, therefore, block tumor growth and disseminative characteristics of taxane-resistant PCa cells. …”
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Deciphering the Molecular Machinery—Influence of sE-Cadherin on Tumorigenic Traits of Prostate Cancer Cells by Igor Tsaur, Anita Thomas, Eva Juengel, Sebastian Maxeiner, Timothy Grein, Quynh Chi Le, Veronika Muschta, Jochen Rutz, Felix K. H. Chun, Roman A. Blaheta

“…Western blot was applied to investigate expression of α3 and β1 integrins as well as cytoskeletal and adhesion proteins. …”
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Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation by Jochen Rutz, Aicha Benchellal, Wajdi Kassabra, Sebastian Maxeiner, August Bernd, Stefan Kippenberger, Nadja Zöller, Felix K.-H. Chun, Eva Juengel, Roman A. Blaheta

“…Phosphorylation of CDK1 decreased and expression of the counter-receptors cyclin A and B was diminished. Integrin α and β subtypes were also reduced, compared to controls. …”
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