Galanin and the endocrine pancreas. by Ahrén, B, Rorsman, P, Berggren, P

Hematopoietic engraftment without beta cell differentiation in the pancreas of bone marrow transplanted normal and diabetic mice by Rosengren, A, Taneera, J, Renstrom, E, Nygren, J, Serup, P, Rorsman, P, Jacobsen, S

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. by Gustavsson, N, Wei, S, Hoang, D, Lao, Y, Zhang, Q, Radda, G, Rorsman, P, Südhof, T, Han, W

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. by Taneera, J, Rosengren, A, Renstrom, E, Nygren, J, Serup, P, Rorsman, P, Jacobsen, SE

“…Herein, adopting the same and alternative approaches to deliver and fate map-transplanted bone marrow cells in the pancreas of normal as well as diabetic mice, we further investigated the potential of bone marrow transplantation as an alternative approach for beta-cell replacement. …”

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. by Rorsman, P, Berggren, P, Bokvist, K, Ericson, H, Möhler, H, Ostenson, C, Smith, P

“…The endocrine part of the pancreas plays a central role in blood-glucose regulation. …”

miR-375 maintains normal pancreatic alpha- and beta-cell mass. by Poy, M, Hausser, J, Trajkovski, M, Braun, M, Collins, S, Rorsman, P, Zavolan, M, Stoffel, M

“…Altered growth and development of the endocrine pancreas is a frequent cause of the hyperglycemia associated with diabetes. …”

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet by Kellard, J, Rorsman, N, Hill, T, van der Bunt, M, Armour, S, Rorsman, P, Knudsen, J, Briant, L

“…Glucagon secretion from isolated islets and in the perfused mouse pancreas was elevated under both hypo- and hyperglycaemic conditions. …”

Type 2 diabetes mellitus: not quite exciting enough? by Ashcroft, F, Rorsman, P

“…We postulate that the electrical activity of the insulin-secreting beta-cells of the pancreas acts to integrate the genetic and environmental factors that predispose to disease risk. …”

DIRECT DETERMINATION OF MANGANESE IN MICROGRAM AMOUNTS OF PANCREATIC TISSUE BY ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROMETRY by Rorsman, P, Berggren, P

“…At the most sensitive wavelength (279.5 nm), down to 0.2 pmol of manganese can be measured in the perifusion medium as well as the endogenous manganese in the endocrine and exocrine parts of the pancreas. The latter values were 0.08 ± 0.01 and 0.16 ± 0.01 mmol Mn kg-1 (dry wt.), respectively. …”

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. by Rorsman, P, Bokvist, K, Ammälä, C, Arkhammar, P, Berggren, P, Larsson, O, Wåhlander, K

“…Insulin is produced and secreted by the B cells in the endocrine pancreas. In vivo, insulin secretion is under the control of a number of metabolic, neural and hormonal substances. …”

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes by Kim, A, Knudsen, J, Madara, J, Benrick, A, Hill, T, Abdul Kadir, L, Kellard, J, Mellander, L, Miranda, C, Lin, H, James, T, Suba, K, Spigelman, A, Wu, Y, MacDonald, P, Wenstedt Asterholm, I, Magnussen, T, Christensen, M, Visboll, T, Salem, V, Knop, F, Rorsman, P, Lowell, B, Briant, L

“…Varying glucose over the range of concentrations that occur physiologically between the fed and fuel-deprived states (8 to 4 mM) has no significant effect on glucagon secretion in the perfused mouse pancreas or in isolated mouse islets (in vitro), and yet associates with dramatic increases in plasma glucagon. …”

Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. by Collins, S, Hoppa, M, Walker, J, Amisten, S, Abdulkader, F, Bengtsson, M, Fearnside, J, Ramracheya, R, Toye, A, Zhang, Q, Clark, A, Gauguier, D, Rorsman, P

“…Insulin secretion in vitro was studied using static incubations and a perfused pancreas preparation. Membrane currents, electrical activity, and exocytosis were examined by patch-clamp technique measurements. …”

Manganese accumulation in pancreatic beta-cells and its stimulation by glucose. by Rorsman, P, Berggren, P, Hellman, B

“…The islet content of endogenous manganese was 80 mumol/kg dry wt., which is about half as much as found in the exocrine pancreas. The initial uptake was characterized by two components, with approximate Km values of 35 microM and 3.7 microM respectively. …”