Ischemic Brain Neurodegeneration by Ryszard Pluta

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Neuroinflammation in Post-Ischemic Neurodegeneration of the Brain: Friend, Foe, or Both? by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

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Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

“…Thus, the knowledge of new neurodegenerative mechanisms that cause neurodegeneration of the hippocampus after ischemia, resembling Alzheimer’s disease proteinopathy, will provide the most important therapeutic development goals to date.…”
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The Dual Role of Autophagy in Postischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy by Ryszard Pluta

“…In addition, the importance of autophagy in neurodegeneration after cerebral ischemia has been highlighted. …”
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Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia by Marzena Ułamek-Kozioł, Stanisław J. Czuczwar, Sławomir Januszewski, Ryszard Pluta

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Myricetin as a Promising Molecule for the Treatment of Post-Ischemic Brain Neurodegeneration by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

“…The available drug therapy for post-ischemic neurodegeneration of the brain is symptomatic. This review provides an evaluation of possible dietary therapy for post-ischemic neurodegeneration with myricetin. …”
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Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia by Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J. Czuczwar

“…We present the latest data that Alzheimer’s disease-related proteins and their genes play a crucial role in postischemic neurodegeneration. Understanding the underlying processes of linking Alzheimer’s disease-related proteins and their genes in development of postischemic neurodegeneration will provide the most significant goals to date for therapeutic development.…”
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The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type by Ryszard Pluta, Stanisław J. Czuczwar, Sławomir Januszewski, Mirosław Jabłoński

“…Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology. …”
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Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Possible Therapeutic Role of Curcumin by Ryszard Pluta, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Stanisław J. Czuczwar

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Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease by Ryszard Pluta, Liang Ouyang, Sławomir Januszewski, Yang Li, Stanisław J. Czuczwar

“…In this review, we summarize protein alterations associated with Alzheimer's disease and their gene expression (<i>amyloid protein precursor</i> and <i>tau protein</i>) after cerebral ischemia, as well as their roles in post-ischemic hippocampus neurodegeneration. In recent years, multiple studies aimed to elucidate the post-ischemic processes in the development of hippocampus neurodegeneration. …”
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Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids by Ryszard Pluta, Barbara Miziak, Stanisław J. Czuczwar

“…Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. …”
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Ischemia-Reperfusion Programming of Alzheimer’s Disease-Related Genes—A New Perspective on Brain Neurodegeneration after Cardiac Arrest by Ryszard Pluta, Stanisław J. Czuczwar

“…Finally, the results clearly indicate that changes in the expression of the presented genes play an important role in acute and secondary brain damage and the development of post-ischemic brain neurodegeneration with the Alzheimer’s disease phenotype. …”
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Post-Ischemic Permeability of the Blood–Brain Barrier to Amyloid and Platelets as a Factor in the Maturation of Alzheimer’s Disease-Type Brain Neurodegeneration by Ryszard Pluta, Barbara Miziak, Stanisław J. Czuczwar

“…The aim of this review is to present evidence of the impact of ischemic changes in the blood–brain barrier on the maturation of post-ischemic brain neurodegeneration with features of Alzheimer’s disease. …”
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Cross-Talk between Amyloid, Tau Protein and Free Radicals in Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy by Ryszard Pluta, Jacek Kiś, Sławomir Januszewski, Mirosław Jabłoński, Stanisław J. Czuczwar

“…Finally, we hypothesize that modified amyloid and the tau protein, along with the oxidative stress generated, are new key elements in the vicious circle important in the development of post-ischemic neurodegeneration in a type of Alzheimer’s disease proteinopathy.…”
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Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality? by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

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<i>Trans</i>- and <i>Cis</i>-Phosphorylated Tau Protein: New Pieces of the Puzzle in the Development of Neurofibrillary Tangles in Post-Ischemic Brain Neurodegeneration of the Alzheimer’s Disease-like Type by Ryszard Pluta, Stanisław J. Czuczwar

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Melatonin: A Potential Candidate for the Treatment of Experimental and Clinical Perinatal Asphyxia by Ryszard Pluta, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Agata Tarkowska

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Alzheimer’s Disease Associated <i>Presenilin 1</i> and <i>2</i> Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia by Agata Tarkowska, Wanda Furmaga-Jabłońska, Jacek Bogucki, Janusz Kocki, Ryszard Pluta

“…We believe that the expression of <i>presenilin</i> genes in lymphocytes could be a potential biomarker to determine the severity of the post-asphyxia neurodegeneration or to identify the underlying factors for brain neurodegeneration and get information about the time they occurred. …”
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Anti-Epileptogenic Effects of Antiepileptic Drugs by Barbara Miziak, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, Stanisław J. Czuczwar

“…Two questions thus arise: (1) Are AEDs able to inhibit SE-induced neurodegeneration? and (2) if so, can a probable neuroprotective potential of particular AEDs stop epileptogenesis? …”
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Preservation of Biomarkers Associated with Alzheimer’s Disease (Amyloid Peptides 1-38, 1-40, 1-42, Tau Protein, Beclin 1) in the Blood of Neonates after Perinatal Asphyxia by Agata Tarkowska, Wanda Furmaga-Jabłońska, Jacek Bogucki, Janusz Kocki, Ryszard Pluta

“…We decided to evaluate serum biomarkers of neuronal injury characteristic for Alzheimer’s disease such as amyloid peptides (1-38, 1-40 and 1-42), tau protein and beclin 1, which can predict the progression of brain neurodegeneration in future. In this paper, we report for the first time the significant changes in the above molecules in the blood after asphyxia compared to healthy controls during the 1–7, 8–14 and 15+ days ELISA test.…”
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