Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations. by Dupuis, C, Storr, H, Perry, L, Ho, J, Ahmed, L, Ong, K, Dunger, D, Monson, J, Grossman, AB, Besser, G, Savage, M

“…A4, DHEAS, T, SHBG, LH and FSH did not correlate with midnight cortisol, but A4 and T SDS correlated with ACTH at 09.00 h (both r = 0.51). …”

Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. by Peters, C, Ahmed, M, Storr, H, Davies, K, Martin, L, Allgrove, J, Grossman, AB, Savage, M

“…No relationships were found with midnight cortisol, ACTH, DHEA-S or cortisol suppression during the low-dose dexamethasone suppression test. …”

Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy. by Chan, L, Storr, H, Plowman, P, Perry, L, Besser, G, Grossman, AB, Savage, M

“…Out of 12, 11 patients were cured by RT (cure interval 0.13-2.86 years) defined by mean serum cortisol of <150 nmol/l on 5-point day curve and midnight sleeping cortisol of <50 nmol/l. Long-term data are available for six male patients, who received RT at the age of 7.0-17.6 years. …”

Bone mineral density at diagnosis and following successful treatment of pediatric Cushing's disease. by Scommegna, S, Greening, J, Storr, H, Davies, K, Shaw, N, Monson, J, Grossman, AB, Savage, M

“…L2-L4 vBMD Z-score values correlated negatively with midnight cortisol (p < 0.05). In Group 2, mean L2-L4 vBMD was -0.38 (-1.0-0.13); and in 7/11, mean femoral neck (FN) areal (a)BMD Z-score was 0.14 (-1.62-2.46). …”

Clinical features, diagnosis, treatment and molecular studies in paediatric Cushing's syndrome due to primary nodular adrenocortical hyperplasia. by Storr, H, Mitchell, H, Swords, F, Main, K, Hindmarsh, P, Betts, P, Shaw, N, Johnston, D, Clark, A, Reznek, R, Grossman, AB, Savage, M

“…The diagnosis of CS was based on elevation of sleeping midnight serum cortisol and urinary free cortisol excretion, and impaired suppression of cortisol on both low- and high-dose dexamethasone suppression tests (DST). …”

Cushing's disease in childhood: presentation, investigation, treatment and long-term outcome. by Savage, M, Lienhardt, A, Lebrethon, M, Johnston, L, Huebner, A, Grossman, AB, Afshar, F, Plowman, P, Besser, G

“…Cushing's disease was confirmed by detectable serum ACTH, median 28 ng/l (range 12-99, NR <10-50) (n = 15); loss of cortisol circadian rhythm values at midnight ranging from 216 to 1,080 nmol/l (NR <50) (n = 15); lack of cortisol suppression (NV < 50 nmol/l) during low-dose dexamethasone suppression test (LDDST) (0.5 mg 6-hourly x 8) (n = 14); and >50% suppression of cortisol compared with the basal value during high-dose dexamethasone suppression test (HDDST) (2 mg 6-hourly x 8) (n = 14). …”