Decoding the complexity of delayed wound healing following Enterococcus faecalis infection by Celik, Cenk, Lee, Stella Tue Ting, Tanoto, Frederick Reinhart, Veleba, Mark, Kline, Kimberly, Thibault, Guillaume

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T-cell death following immune activation is mediated by mitochondria-localized SARM by Ho, B., Chen, J., Singh, L. P., Selvarajan, V., Ng, S. B., Tan, N. S., Panneerselvam, P., Chng, Wee Joo, Ding, Jeak Ling

“…Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. …”
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Isolation and fermentation of endophytic fungi from Singapore plants followed by isolation of active compounds from fungi extract. by Lim, Russell Tse Jiang.

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A novel strategy for the discrimination of gelatinous Chinese medicines based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detection by Yang, Huan, Shen, Yuping, Xu, Ying, Zheng, Jie, Wu, Qinan, Maqueda, Aida Serra, Tam, James Pingkwan

“…In this study, our efforts to differentiate three gelatinous Chinese medicines, Asini Corii Colla, Cervi Cornus Colla, and Testudinis Carapacis ET Plastri Colla, are presented, and a novel strategy based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detector analysis is proposed herein. …”
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Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy by Reza, Musarrat Maisha, Subramaniyam, Nathiya, Sim, Chu Ming, Ge, Xiaojia, Sathiakumar, Durgalakshmi, McFarlane, Craig, Sharma, Mridula, Kambadur, Ravi

“…In addition, irisin injection rescues loss of skeletal muscle mass following denervation by enhancing satellite cell activation and reducing protein degradation. …”
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A contemporary snapshot of intestinal stem cells and their regulation by Seishima, Ryo, Barker, Nick

“…Recent studies have also shown that the ISC niche can reprogram differentiated cells to replenish lost ISCs following tissue injury, accounting for the epithelial cell plasticity within the crypt compartment. …”
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Study on stem cell plasticity in plants. by Seah, Seng Wee.

“…Interestingly, flowers can be reconstituted following killing of cells containing FM. It is postulated that adjacent cells in the vicinity of the FM can take on meristem identity, hence generating multiple ectopic meristem centers. …”
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Multiplex gene array and immunohistochemical analysis with clinical pathological correlation for lung sarcomatoid carcinoma. by Zhuang, Yan.

“…IHC profiling also showed the following markers to be overexpressed in PC: FGFR2 (75%), HGF (63%) and c-Met (13%). …”
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In vitro experimental systems for studying ecological relevance of novel mycelial-like biofilms of legionella pneumophila. by Sze, Chun Chau.

“…This project aimed to establish in vitro systems for the following purposes: (1) Identification and characterization of the genetic regulatory elements - promoters, operators, regulators - involved in the temperature-dependent filamentation of L. pneumophila in biofilms…”
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Matricellular proteins : a sticky affair with cancers by Chong, Han Chung, Tan, Chek Kun, Huang, Royston-Luke, Tan, Nguan Soon

“…Herein, we review the current understanding of the following matricellular proteins and highlight their pivotal and multifacted roles in metastatic progression: angiopoietin-like protein 4 (ANGPTL4), CCN family members cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) and CCN6, osteopontin (OPN), secreted protein acidic and rich in cysteine (SPARC), tenascin C (TNC), and thrombospondin-1 and -2 (TSP1, TSP2). …”
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YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity by Tang, Kai, Wang, Meitian, Feng, Shu, Chen, Yun, Kamada, Katsuhiko, Wang, Han, Gao, Yong-Gui

“…In addition, mass spectrometry data indicated that YoeB cleaves mRNA following the second position at the A-site codon, resulting in a final product with a 3′–phosphate at the newly formed 3′ end. …”
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Plant-like bacterial expansins play contrasting roles in two tomato vascular pathogens by Tancos, Matthew A., Lowe-Power, Tiffany M., Peritore-Galve, F. Christopher, Tran, Tuan Minh, Allen, Caitilyn, Smart, Christine D.

“…In contrast, the Rs ΔRsEXLX mutant showed reduced virulence on tomato following root inoculation, but not following direct petiole inoculation, suggesting that the RsEXLX expansin contributes to early virulence at the root infection stage. …”
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Lgr5 marks adult progenitor cells contributing to skeletal muscle regeneration and sarcoma formation by Leung, Carly, Katzrin Bte Ahmad Murad, Tan, Adelyn Liang Thing, Yada, Swathi, Sagiraju, Sowmya, Bode, Peter Karl, Barker, Nick

“…Lgr5 is found to be rapidly upregulated in purified myogenic progenitors following acute cardiotoxin-induced injury. In vivo lineage tracing using our Lgr5-2ACreERT2R26tdTomatoLSL reporter mouse model shows that Lgr5+ cells can reconstitute damaged muscle fibers following muscle injury, as well as replenish the quiescent satellite cell pool. …”
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Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target by Wagner, Matthias Paulus, Formaglio, Pauline, Gorgette, Olivier, Dziekan, Jerzy Michal, Huon, Christèle, Berneburg, Isabell, Rahlfs, Stefan, Barale, Jean-Christophe, Feinstein, Sheldon I., Fisher, Aron B., Ménard, Didier, Bozdech, Zbynek, Amino, Rogerio, Touqui, Lhousseine, Chitnis, Chetan E.

“…Furthermore, inhibition of PRDX6 synergistically reduces the survival of artemisinin-resistant parasites following co-treatment of parasite cultures with artemisinin and Darapladib. …”
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How histone modifications change nucleosome stability : FRET studies on single molecules and in bulk by Langowski, Jörg, Tóth, Katalin, Gansen, Alexander, Hetey, Szabolcs, Székvölgyi, Loránd, Nordenskiöld, Lars

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Control of Ras/Erk signalling pathway by the brahma chromatin-remodelling complex. by Siti Nur Ain Roesley.

“…Analysis of components in this pathway at both the transcriptional and protein levels following overexpression of wild-type Brahma in Drosophila S2 cells, demonstrated that Brahma may affect EGFR mRNA expression and Ras protein level. …”
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Genetic and epigenetic responses of normal and cancer cells to Panax notoginseng. by Wang, Meiling.

“…Genetic and Epigenetic differences were also detected in MRC5 (non-transformed lung cells), following steamed PNG water extract treatment. RAPD profiles of chicken embryonic fibroblasts (McrBC digested) also revealed epigenetic changes in a dose-dependent response for high concentrations of steamed water and methanol PNG extracts. …”
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Relationship between the benthic communities in southern islands of Singapore. by Lim, Elton Wenxiong.

“…Understanding the factors that affect settlement and recruitment of corals is of great importance as these processes are critical in the persistence and recovery of reefs following disturbances. In this study, five reef sites were chosen along the southern islands of Singapore to (1) examine seasonal differences in settlement of benthic organisms during the northeast monsoon and during the two main coral spawning periods, (2) compare the relationship between algal cover and coral recruit abundance during the coral spawning periods, and (3) provide insights on the impact on the benthic assemblages within Singapore coastal waters. …”
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The use of nuclear magnetic resonance in study of structurally dynamic membrane proteins by Phillips, Margaret

“…In particular our focus was on the following proteins: human Stromal Interaction Molecule 1 (hSTIM1), human Presenilin Enhancer-2 (hPEN-2) and E.coli water channel Aquaporin Z (AqpZ).…”
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The combination of Chinese and Western Medicine in the management of rheumatoid arthritis: a real-world cohort study across China by Zhong, Linda Lidan, Wang, Rongsheng, Lam, Wai Ching, Zhu, Qi, Du, Peipei, Cao, Peihua, Jiang, Ting, Zhang, Yuanyuan, Shen, Jie, Su, Xiao, Xue, Luan, Mao, Jianchun, Fang, Yongfei, Gao, Mingli, Hu, Chunrong, Peng, Jiangyun, Gu, Ying, Wei, Qianghua, Huang, Runyue, Lyu, Aiping, Liu, Hongxia, He, Dongyi

“…Results: A total of 3195 patients with RA received IM (n = 1379, 43.2%) or WM (n = 1816, 56.8%). Following 1:1 propensity score matching, 1,331 eligible patients prescribed IM were compared to 1,331 matched patients prescribed WM. …”
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