PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells by Groh, Ann-Christin, Möller-Kerutt, Annika, Gilhaus, Kevin, Höffken, Verena, Nedvetsky, Pavel, Kleimann, Simon, Behrens, Malina, Ghosh, Sujasha, Hansen, Uwe, Krahn, Michael P., Ebnet, Klaus, Pavenstädt, Hermann, Ludwig, Alexander, Weide, Thomas

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Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms by Yap, Karen, Xiao, Yixin, Friedman, Brad A., Je, H. Shawn, Makeyev, Eugene V.

“…In an important example of this scenario, cell polarity gene Cdc42, a combination of polypyrimidine tract-binding, protein-dependent, and constitutive splicing mechanisms ensures a halfway switch from the general (E7) to the neuron-specific (E6) alternative 30-terminal exon during neuronal differentiation. …”
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The mammalian crumbs complex defines a distinct polarity domain apical of epithelial tight junctions by Tan, Benedict, Siti Maryam J. M. Yatim, Peng, Suat, Gunaratne, Jayantha, Hunziker, Walter, Ludwig, Alexander

“…Taken together, our work defines the spatial and molecular organization of the apical-lateral border in mammalian epithelial cells, reveals an intriguing molecular and spatial conservation of invertebrate and vertebrate cell polarity protein domains, and identifies a VMZ-associated protein network implicated in HIPPO signaling and the control of the cortical actin cytoskeleton.…”
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Rho GTPases and regulation of cell migration, polarization and adhesion proteins in wounding assay of human corneal epithelial cells by Gan, Kah Hui

“…This study suggests that Rho proteins influence cell migration through its effect on cell polarization, a critical step in cell movement. Modulation of migration of these cells targeting the Rho proteins has potential therapeutic implications.…”
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X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis by Jain, Neeraj, Tan, Jun Hou, Feng, Shijin, George, Bhawana, Thanabalu, Thirumaran

“…In addition JurkatWASP-KD T cells expressing these two WASP mutants were found to be defective in T cell polarization when stimulated with SDF-1α. WASP exists in a closed conformation in the presence of WIP, however both the mutants (WASPRL46P and WASPRA47D) were found to be in an open conformation as determined in the bi-molecular complementation assay. …”
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