White matter abnormalities in major depression. by Tham, Leonard Ming Wei.

“…Of late, there is more focus on understanding the white matter changes in psychiatric disorders including Major Depressive Disorder (MDD). Such studies can investigate white matter pathology along several fronts, namely understanding the brain white matter volume changes, connectivity disruptions, as well as genetic factors underpinning MDD. …”
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Substrate-binding glycine residues are major determinants for hydrolase and ligase activity of plant legumains by Hemu, Xinya, Chan, Ning-Yu, Liew, Heng Tai, Hu, Side, Zhang, Xiaohong, Serra, Aida, Lescar, Julien, Liu, Chuan-Fa, Tam, James P.

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Absolute quantitation of major human tear proteins using multiple reaction monitoring (MRM)-based mass spectrometry by Hu, Weishan

“…In this study, stable isotope-labeled standard peptides and LC-MRM/MS were used to develop method for absolute quantitation of major human tear proteins. Triplicate Global Control (GC) tear samples were prepared to evaluate on the reproducibility of their peak area and retention time. …”
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The unique C-terminal extension of mycobacterial F-ATP synthase subunit α is the major contributor to its latent ATP hydrolysis activity by Wong, Chui-Fann, Grüber, Gerhard

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Great tits (Parus major) flexibly learn that herbivore-induced plant volatiles indicate prey location : an experimental evidence with two tree species by Sam, Katerina, Kovarova, Eliska, Freiberga, Inga, Uthe, Henriette, Weinhold, Alexander, Jorge, Leonardo R., Sreekar, Rachakonda

“…When searching for food, great tits (Parus major) can use herbivore-induced plant volatiles (HIPVs) as an indicator of arthropod presence. …”
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Construction sites as an important driver of dengue transmission: implications for disease control by Tang, Choon-Siang, Rajarethinam, Jayanthi, Koo, Carmen, Liang, Shaohong, Hapuarachchi, Hapuarachchige Chanditha, Chong, Chee-Seng, Ng, Lee-Ching, Yap, Grace

“…We explored the odds of construction site-associated clusters growing into major clusters and determined whether clusters seeded in construction sites demonstrated a higher tendency to expand into major clusters. …”
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The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors by Selkrig, Joel, Mohammad, Farhan, Ng, Soon Hwee, Chua, Jia Yi, Tumkaya, Tayfun, Ho, Joses, Chiang, Yin Ning, Rieger, Dirk, Pettersson, Sven, Helfrich-Förster, Charlotte, Yew, Joanne Y., Claridge-Chang, Adam

“…We proposed the hypothesis that the microbiome has a major influence on the behavior of the vinegar fly (Drosophila melanogaster), a major invertebrate model organism. …”
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Extracellular protein isolation from the matrix of anammox biofilm using ionic liquid extraction by Wong, Lan Li, Natarajan, Gayathri, Boleij, Marissa, Thi, Sara Swa, Winnerdy, Fernaldo Richtia, Mugunthan, Sudarsan, Lu, Yang, Lee, Jong-Min, Lin, Yuemei, van Loosdrecht, Mark, Law, Yingyu, Kjelleberg, Staffan, Seviour, Thomas

“…Ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate and N,N-dimethylacetamide (EMIM-Ac/DMAc) mixture was applied to extract the major structural proteins. Further treatment by anion exchange chromatography isolated homologous serine (S)- and threonine (T)-rich proteins BROSI_A1236 and UZ01_01563, which were major components of the extracted proteins, and sequentially highly similar to putative anammox extracellular proteins KUSTD1514 and WP_070066018.1 of Ca. …”
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Fungal Secretome for Biorefinery: Recent Advances in Proteomic Technology by Adav, Sunil S., Sze, Siu Kwan

“…Therefore, in this review, we reviewed more commonly used different proteomic techniques for profiling fungal secretome with a major focus on two dimensional gel electrophoresis, liquid chromatography-based quantitative mass spectrometry for global protein identification and quantification. …”
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Understanding missing proteins : a functional perspective by Zhou, Longjian, Wong, Limsoon, Goh, Wilson Wen Bin

“…We assert that informatics-driven solutions would have a major role in resolving the MP problem (MPP).…”
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Transcriptional levels of calcium handling genes in atrial cells of heart failure patients. by Wong, Ying Lei.

“…Heart failure has been a major cause of concern as it is one of the major causes of deaths worldwide. …”
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Cyclic di-AMP oversight of counter-ion osmolyte pools impacts intrinsic cefuroxime resistance in Lactococcus lactis by Pham, Huong Thi, Shi, Wen, Xiang, Yuwei, Foo, Su Yi, Plan, Manuel R., Courtin, Pascal, Chapot-Chartier, Marie-Pierre, Smid, Eddy J., Liang, Zhao-Xun, Marcellin, Esteban, Turner, Mark S.

“…Evidence is also presented showing that they are major osmolytes that enhance osmoresistance and cell lysis. …”
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Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevent host invasion of divergent plasmodial species by Chandramohanadas, Rajesh, Russell, B., Basappa, Liew, K., Yau, Y. H., Chong, A., Min, L., Gunalan, K., Raman, R., Renia, L., Nosten, F., Shochat, S. G., Dao, M., Sasisekharan, R., Suresh, S., Preiser, P.

“…Combining multi-disciplinary approaches, we report the discovery of a small molecule inhibitor, NIC capable of inhibiting host invasion through interacting with a major invasion-related protein, merozoite surface protein-1 (MSP-1). …”
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Heterochromatin Protein 1 Secures Survival and Transmission of Malaria Parasites by Brancucci, Nicolas M.B., Bertschi, Nicole L., Zhu, Lei, Niederwieser, Igor, Chin, Wai Hoe, Wampfler, Rahel, Freymond, Céline, Rottmann, Matthias, Felger, Ingrid, Bozdech, Zbynek, Voss, Till S.

“…These findings show that PfHP1 is centrally involved in clonally variant gene expression and sexual differentiation in P. falciparum and have major implications for developing antidisease and transmission-blocking interventions against malaria.…”
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Commercial processed soy-based food product contains glycated and glycoxidated lunasin proteoforms by Serra, Aida, Gallart-Palau, Xavier, See-Toh, Rachel Su-En, Hemu, Xinya, Sze, Siu Kwan, Tam, James Pingkwan

“…Nutraceuticals have been proposed to exert positive effects on human health and confer protection against many chronic diseases. A major bioactive component of soy-based foods is lunasin peptide, which has potential to exert a major impact on the health of human consumers worldwide, but the biochemical features of dietary lunasin still remain poorly characterized. …”
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Molecular basis of the key regulator WRINKLED1 in plant oil biosynthesis by Qiao, Zhu, Kong, Que, Tee, Wan Ting, Lim, Audrey R. Q., Teo, Miao Xuan, Olieric, Vincent, Low, Pui Man, Yang, Yuzhou, Qian, Guoliang, Ma, Wei, Gao, Yong-Gui

“…Vegetable oils are not only major components of human diet but also vital for industrial applications. …”
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Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model by Obaldía, Nicanor, Da Silva Filho, Joao Luiz, Núñez, Marlon, Glass, Katherine A., Oulton, Tate, Achcar, Fiona, Wirjanata, Grennady, Duraisingh, Manoj, Felgner, Philip, Tetteh, Kevin Ka, Bozdech, Zbynek, Otto, Thomas D., Marti, Matthias

“…The malaria parasite Plasmodium vivax remains a major global public health challenge, and no vaccine is approved for use in humans. …”
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Pseudomonas Aeruginosa Oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis by Chen, Fei, Chen, Gukui, Liu, Yiwei, Jin, Yongxin, Cheng, Zhihui, Liu, Yang, Yang, Liang, Jin, Shouguang, Wu, Weihui

“…In Pseudomonas aeruginosa, it has been demonstrated that Orn plays a major role in the hydrolysis of pGpG, which is required for cyclic-di-GMP homeostasis. …”
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How potassium came to be the dominant biological cation : of metabolism, chemiosmosis, and cation selectivity since the beginnings of life by Korolev, Nikolay

“…In the cytoplasm of practically all living cells, potassium is the major cation while sodium dominates in the media (seawater, extracellular fluids). …”
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Transcriptional regulation during aberrant activation of NF-κB signalling in cancer by Deka, Kamalakshi, Li, Yinghui

“…The NF-κB signalling pathway is a major signalling cascade involved in the regulation of inflammation and innate immunity. …”
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