Imaging analysis of human metapneumovirus-infected cells provides evidence for the involvement of F-actin and the raft-lipid microdomains in virus morphogenesis by Jumat, Muhammad Raihan, Nguyen Huong, Tra, Wong, Puisan, Loo, Liat Hui, Tan, Boon Huan, Fenwick, Fiona, Toms, Geoffrey L., Sugrue, Richard J.

“…The similarity between HMPV morphogenesis and the closely related human respiratory syncytial virus suggests that involvement of F-actin and lipid-raft microdomains in virus morphogenesis may be a common feature of the Pneumovirinae.…”
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An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis. by Torres, Jaume.

“…All coronaviruses encode a small hydrophobic envelope (E) protein, which mediates viral assembly and morphogenesis by an unknown mechanism. When E proteins are synthesized alone, they reconfigure intracellular membranous organelles or induce secretion of exosomal vesicles when overexpressed. …”
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Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly by Ravi, Laxmi Iyer, Huan, Tan Boon, Ludwig, Alexander, Nguyen, Tra Huong, Leong, Daniel, Sandin, Sara, Sugrue, Richard J.

“…Respiratory syncytial virus (RSV) is an enveloped virus that assembles into filamentous virus particles on the surface of infected cells. Morphogenesis of RSV is dependent upon cholesterol-rich (lipid raft) membrane microdomains, but the specific role of individual raft molecules in RSV assembly is not well defined. …”
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Expression and purification of coronavirus envelope proteins using a modified β-barrel construct by Pervushin, Konstantin, Torres, Jaume, Parthasarathy, Krupakar, Lu, Huang, Surya, Wahyu, Vararattanavech, Ardcharaporn

“…These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. …”
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Quantitative proteomic analysis of secretome of microbial consortium during saw dust utilization by Ravindran, Anita, Cheow, Esther Sok Hwee, Sze, Siu Kwan, Adav, Sunil S.

“…The functional classification of the secretory proteins by individual culture and co-culture demonstrated 36.77% cellulolytic proteins, 13.06% hemicellulases, 14.09% ligninolytic proteins, 19.59% proteolytic enzymes. 7.22% hypothetical proteins and 6.87% cell morphogenesis proteins. The abundance of the proteins by individual cultures and co-cultured fungal consortium revealed that co-culturing of Phanerochaete chrysosporium with Trichoderma reesei QM6a and Trichoderma reesei Rut C30 induced the production of cellulolytic proteins and stimulated expression of hemicellulolytic enzymes. …”
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Trimerization of the N-terminal tail of Zika virus NS4A protein : a potential in vitro antiviral screening assay by To, Janet, Torres, Jaume

“…The nonstructural (NS) protein NS4A in flaviviruses is a membrane protein that is critical for virulence, and, among other roles, it participates in membrane morphogenesis. In dengue virus (DENV), the NS4A hydrophilic N–terminal tail, together with the first transmembrane domain, is involved in both homo-oligomerization and hetero–oligomerization with NS4B. …”
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Cellular senescence: mechanisms and therapeutic potential by Liao, Zehuan, Yeo, Han Lin, Wong, Siaw Wen, Zhao, Yan

“…While phenotypically diverse, characteristics of senescence include the expression of the senescence-associated secretory phenotype, cell cycle arrest factors, senescence-associated β-galactosidase, morphogenesis, and chromatin remodelling. Persistent senescence is associated with pathologies such as aging, while transient senescence is associated with beneficial programmes, such as limb patterning. …”
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Hypoxia activated EGFR signaling induces epithelial to mesenchymal transition (EMT) by Misra, Ashish, Pandey, Chhiti, Sze, Siu Kwan, Thanabalu, Thirumaran

“…EMT is essential during embryonic morphogenesis and has been implicated in the progression of primary tumors towards metastasis. …”
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Virus-induced activation of the rac1 protein at the site of respiratory syncytial virus assembly is a requirement for virus particle assembly on infected cells by Ravi, Laxmi Iyer, Tan, Timothy J., Tan, Boon Huan, Sugrue, Richard J.

“…RSV infection led to increased rac1 protein activation, and using the rac1 protein inhibitor NS23766 we provided evidence that the increased rac1 activation occurred at the site of RSV assembly and facilitated F-actin remodeling during virus morphogenesis. A non-infectious virus-like particle (VLP) assay showed that the RSV VLPs formed in lipid-raft microdomains containing the rac1 protein, together with F-actin and filamin-1 (cell proteins associated with virus filaments). …”
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Cpk2, a Catalytic Subunit of Cyclic AMP-PKA, Regulates Growth and Pathogenesis in Rice Blast by Naqvi, Naweed Isaak, Selvaraj, Poonguzhali, Shen, Qing, Yang, Fan

“…Our studies indicate that CpkA and Cpk2 share overlapping functions, but also play distinct roles during pathogenesis-associated signaling and morphogenesis in the rice blast fungus.…”
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Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity by Chng, Song Hui, Kundu, Parag, Dominguez-Brauer, Carmen, Teo, Wei Ling, Mak, Tak Wah, Pettersson, Sven, Kawajiri, Kaname, Fujii-Kuriyama, Yoshiaki

“…Here, we report that Cre-mediated deletion of AhR in CD11c-expressing cells in C57/BL6 mice is associated with altered intestinal epithelial morphogenesis in vivo. Moreover, when co-cultured with AhR-deficient DCs ex vivo, intestinal organoids showed reduced SRY (sex determining region Y)-box 9 and increased Mucin 2 expression, which correlates with reduced Paneth cells and increased goblet cell differentiation, similar to the data obtained in vivo. …”
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The cytoplasmic N-terminal tail of Zika virus NS4A protein forms oligomers in the absence of detergent or lipids by Surya, Wahyu, Liu, Yiting, Torres, Jaume

“…The non-structural (NS) NS4A protein in flaviviruses has three predicted transmembrane domains, is critical for virulence and participates in membrane morphogenesis. In Dengue virus (DENV), both hydrophylic N-terminal tail and its first transmembrane domain participate in the formation of oligomers which are important for pathogenicity. …”
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The mammalian crumbs complex defines a distinct polarity domain apical of epithelial tight junctions by Tan, Benedict, Siti Maryam J. M. Yatim, Peng, Suat, Gunaratne, Jayantha, Hunziker, Walter, Ludwig, Alexander

“…The AJC is composed of tight junctions (TJ) and adherens junctions (AJ) and plays fundamental roles in epithelial morphogenesis and plasticity. However, the molecular composition and precise sub-junctional organization of the AJC and its associated polarity regulators are not well defined. …”
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The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration by Wong, Darren Chen Pei, Pan, Catherine Qiurong, Er, Shi Yin, Thivakar, T., Tan, Rachel Zi Yi, Seah, Sock Hong, Chua, Pei Jou, Jiang, Tingting, Chew, Ti Weng, Chaudhuri, Parthiv Kant, Mukherjee, Somsubhro, Salim, Agus, Aye, Thike Aye, Koh, Cheng Gee, Lim, Chwee Teck, Tan, Puay Hoon, Bay, Boon Huat, Ridley, Anne J., Low, Boon Chuan

“…Rho GTPases regulate cell morphogenesis and motility under the tight control of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). …”
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