Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling by Adav, Sunil Shankar, Sze, Siu Kwan

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Modulation of sphingolipids, cholesterol and saturated fatty acids interact with the neurodegeneration in the Drosophila blue cheese mutant. by Boo, George.

“…To elucidate the association between aberrant metabolism of lipids and age-related neurodegeneration, we study the Drosophila neurodegenerative blue cheese (bchs) mutant. bchs is associated with lysosomal trafficking and autophagosomal degradation of aggregated proteins. …”
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Liver's influence on the brain through the action of bile acids by Yeo, Xin Yi, Tan, Li Yang, Chae, Woo Ri, Lee, Dong-Yup, Lee, Yong-An, Wuestefeld, Torsten, Jung, Sangyong

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Uncovering Neurodegenerative Protein Modifications via Proteomic Profiling by Gallart-Palau, Xavier, Serra, Aida, Sze, Siu Kwan

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Genetic programs of neuronal degeneration in dendrite arborisation neurons. by Lee, Hui Min.

“…The identification of genes involved in dendrite pruning aided our understanding of the molecular mechanism of neurodegeneration as well as proving that RNAi can be an efficient way to identify novel genes involved in dendrite pruning.…”
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Spinal cord organoids add an extra dimension to traditional motor neuron cultures by Winanto, Khong, Zi-Jian, Hor, Jin-Hui, Ng, Shi-Yan

“…Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. …”
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Brain site-specific proteome changes in aging-related dementia by Manavalan, Arulmani, Mishra, Manisha, Feng, Lin, Sze, Siu Kwan, Akatsu, Hiroyasu, Heese, Klaus

“…Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain site-specific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. …”
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Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR by Gallart-Palau, Xavier, Serra, Aida, Sze, Siu Kwan

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Genome-wide studies of neuronal degeneration in dendrite arborization neurons. by Toh, Jia Yi.

“…Neuronal pruning is a widely observed phenomenon important for the development and refinement of neural circuits to ensure precise and functional connections. Developmental neurodegeneration, a process common to both mammals and Drosophila melanogaster resembles neuronal degeneration in states of neuronal injury and neuronal disorder morphologically. …”
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Chaperone-mediated autophagy : roles in disease and aging by Cuervo, Ana Maria, Wong, Esther

“…Here, we describe recent advances in the understanding of the molecular dynamics, regulation and physiology of CMA and discuss the evidences in support of the contribution of CMA dysfunction to severe human disorders such as neurodegeneration and cancer.…”
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Analyzing roles of sphingolipid in neurodegenerative blue cheese mutants in drosophila by Ishtapran Sahoo

“…We are interested in the involvement of sphingolipids in neurodegeneration in Drosophila. To look at this, we study animals deficient in Blue cheese, a BEACH domain protein involved in autophagy and lysosomal transport, and highly expressed in the nervous system. …”
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The BEACH domain is critical for blue cheese function in a spatial and epistatic autophagy hierarchy by Sim, Joan, Osborne, Kathleen Amy, García, Irene Argudo, Matysik, Artur Stanislaw, Kraut, Rachel

“…Drosophila blue cheese (bchs) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and p62. bchs mutations lead to age-dependent accumulation of ubiquitinated inclusions and progressive neurodegeneration in the fly brain, but neither the influence of autophagy on bchs-related degeneration, nor bchs’ placement in the autophagic hierarchy have been shown. …”
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The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade by Zhao, Lina, Jia, Xueen, Shankar, S K, Olofsson, Anders, Brännström, Thomas, Mu, Yuguang, Gräslund, Astrid, Morozova-Roche, Ludmilla A, Jarvet, Jüri, Wang, Chao, Klechikov, Alexey G, Gharibyan, Anna L, Wärmländer, Sebastian K T S

“…Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific mechanisms of action in Alzheimer’s disease (AD). …”
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iTRAQ Quantitative Clinical Proteomics Revealed Role of Na+K+ -ATPase and Its Correlation with Deamidation in Vascular Dementia by Adav, Sunil S., Qian, Jingru, Ang, Yi Lin, Kalaria, Raj N., Lai, Mitchell K. P., Chen, Christopher P., Sze, Siu Kwan

“…Spontaneous protein deamidation of labile asparagines, generating abnormal l-isoaspartyl residues, is associated with cell aging and dementia due to Alzheimer’s disease and may be a cause of neurodegeneration. As ion channel proteins play important roles in cellular signaling processes, alterations in their function by deamidation may lead to perturbations in membrane excitability and neuronal function. …”
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Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues by Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James Pingkwan, Sze, Siu Kwan

“…Conclusion: UC-coupled proteomics revealed that brain amyloidal plaques are enriched in deamidated proteins, and suggested that altered charge state and calcium-binding capacity of S100A9 may enhance protein aggregation and promote neurodegeneration in the human brain.…”
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Phase separation in biology and disease; current perspectives and open questions by Boeynaems, Steven, Chong, Shasha, Gsponer, Jörg, Holt, Liam, Milovanovic, Dragomir, Mitrea, Diana M., Mueller-Cajar, Oliver, Portz, Bede, Reilly, John F., Reinkemeier, Christopher D., Sabari, Benjamin R., Sanulli, Serena, Shorter, James, Sontag, Emily, Strader, Lucia, Stachowiak, Jeanne, Weber, Stephanie C., White, Michael, Zhang, Huaiying, Zweckstetter, Markus, Elbaum-Garfinkle, Shana, Kriwacki, Richard

“…Further, condensates formed through aberrant phase transitions have been associated with numerous human diseases, prominently including neurodegeneration and cancer. While in some cases, rigorous evidence supports links between formation of biomolecular condensates through phase separation and biological functions, in many others such links are less robustly supported, which has led to rightful scrutiny of the generality of the roles of phase separation in biology and disease.4-7 During a week-long workshop in March 2022 at the Telluride Science Research Center (TSRC) in Telluride, Colorado, ∼25 scientists addressed key questions surrounding the biomolecular condensates field. …”
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Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants by Papan, Cyrus, Osborne, Kathleen Amy, Torta, Federico, Shevchenko, Andrej, Schwudke, Dominik, Kraut, Rachel, Hebbar, Sarita, Sahoo, Ishtapran, Matysik, Artur, Garcia, Irene Argudo, Narayanaswamy, Pradeep, Fun, Xiu Hui, Wenk, Markus R

“…Drosophila blue cheese mutants neurodegenerate due to perturbations in autophagic flux, and consequent accumulation of ubiquitinated aggregates. …”
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