Opioid Analgesic as a Positive Allosteric Modulator of Acid-Sensing Ion Channels by Dmitry I. Osmakov, Lyudmila V. Onoprienko, Aleksandr P. Kalinovskii, Sergey G. Koshelev, Vasiliy N. Stepanenko, Yaroslav A. Andreev, Sergey A. Kozlov

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Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone <i>Heteractis magnifica</i> by Irina N. Gladkikh, Anna A. Klimovich, Rimma S. Kalina, Yulia V. Kozhevnikova, Timur A. Khasanov, Dmitry I. Osmakov, Sergey G. Koshelev, Margarita M. Monastyrnaya, Yaroslav A. Andreev, Elena V. Leychenko, Sergey A. Kozlov

“…In open field and elevated plus maze tests, Hmg 1b-2 had more of an excitatory effect and Hmg 1b-4 had more of an anxiolytic effect on mouse behavior. The analgesic activity of peptides was similar and comparable to diclofenac activity in an acid-induced muscle pain model. …”
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Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds by Yaroslav A. Andreev, Dmitry I. Osmakov, Sergey G. Koshelev, Ekaterina E. Maleeva, Yulia A. Logashina, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Sergey A. Kozlov

“…The bell-shaped dependence of the analgesic effect was observed for APETx2 in the acetic acid-induced writhing test, as well as for sevanol and peptide Ugr9-1 in the thermal hyperalgesia test. …”
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First Anti-Inflammatory Peptide AnmTX Sco 9a-1 from the Swimming Sea Anemone <i>Stomphia coccinea</i> by Rimma S. Kalina, Irina N. Gladkikh, Anna A. Klimovich, Yulia V. Kozhevnikova, Aleksandra N. Kvetkina, Eugene A. Rogozhin, Sergey G. Koshelev, Sergey A. Kozlov, Elena V. Leychenko

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Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia by Yaroslav A. Andreev, Sergey A. Kozlov, Yuliya V. Korolkova, Igor A. Dyachenko, Dmitrii A. Bondarenko, Denis I. Skobtsov, Arkadii N. Murashev, Polina D. Kotova, Olga A. Rogachevskaja, Natalia V. Kabanova, Stanislav S. Kolesnikov, Eugene V. Grishin

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New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties by Yulia A. Logashina, Runar Gjerp Solstad, Konstantin S. Mineev, Yuliya V. Korolkova, Irina V. Mosharova, Igor A. Dyachenko, Victor A. Palikov, Yulia A. Palikova, Arkadii N. Murashev, Alexander S. Arseniev, Sergey A. Kozlov, Klara Stensvåg, Tor Haug, Yaroslav A. Andreev

“…Ueq 12-1 is a unique peptide potentiator of the TRPA1 receptor that produces analgesic and anti-inflammatory effects in vivo. The antinociceptive properties allow us to consider Ueq 12-1 as a potential analgesic drug lead with antibacterial properties.…”
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Sevanol and Its Analogues: Chemical Synthesis, Biological Effects and Molecular Docking by Olga A. Belozerova, Dmitry I. Osmakov, Andrey Vladimirov, Sergey G. Koshelev, Anton O. Chugunov, Yaroslav A. Andreev, Victor A. Palikov, Yulia A. Palikova, Elvira R. Shaykhutdinova, Artem N. Gvozd, Igor A. Dyachenko, Roman G. Efremov, Vadim S. Kublitski, Sergey A. Kozlov

“…Sevanol, a natural lignan isolated from <i>Thymus armeniacus</i>, inhibits the activity of ASIC1a and ASIC3 isoforms, and has a significant analgesic and anti-inflammatory effect. In this work, we described the efficient chemical synthesis scheme of sevanol and its analogues, which allows us to analyze the structure–activity relationships of the different parts of this molecule. …”
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Retinoic Acid-Differentiated Neuroblastoma SH-SY5Y Is an Accessible In Vitro Model to Study Native Human Acid-Sensing Ion Channels 1a (ASIC1a) by Aleksandr P. Kalinovskii, Dmitry I. Osmakov, Sergey G. Koshelev, Kseniya I. Lubova, Yuliya V. Korolkova, Sergey A. Kozlov, Yaroslav A. Andreev

“…This approach can improve the characterization of modulators for the development of new neuroprotective and analgesic drugs.…”
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Dual Modulator of ASIC Channels and GABA_A Receptors from Thyme Alters Fear-Related Hippocampal Activity by Aleksandr P. Kalinovskii, Anton P. Pushkarev, Anastasia D. Mikhailenko, Denis S. Kudryavtsev, Olga A. Belozerova, Vladimir I. Shmygarev, Oleg N. Yatskin, Yuliya V. Korolkova, Sergey A. Kozlov, Dmitry I. Osmakov, Alexander Popov, Yaroslav A. Andreev

“…Sevanol was reported previously as a naturally-occurring ASIC inhibitor from thyme with favorable analgesic and anti-inflammatory activity. Using electrophysiological methods, we found that in the high micromolar range, the compound effectively inhibited homomeric ASIC1a and, in sub- and low-micromolar ranges, positively modulated the currents of α1β2γ2 GABA_A receptors. …”
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Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals by Yanina V. Burgart, Natalia A. Elkina, Evgeny V. Shchegolkov, Olga P. Krasnykh, Galina F. Makhaeva, Galina A. Triandafilova, Sergey Yu. Solodnikov, Natalia P. Boltneva, Elena V. Rudakova, Nadezhda V. Kovaleva, Olga G. Serebryakova, Mariya V. Ulitko, Sophia S. Borisevich, Natalia A. Gerasimova, Natalia P. Evstigneeva, Sergey A. Kozlov, Yuliya V. Korolkova, Artem S. Minin, Anna V. Belousova, Evgenii S. Mozhaitsev, Artem M. Klabukov, Victor I. Saloutin

“…Most of the 4-AHPs exhibited a pronounced analgesic effect in a hot plate test in vivo at and above the diclofenac and metamizole levels except for the ones with two chlorine atoms in the aryl group. …”
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