A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block by Tomek, J, Bueno-Orovio, A, Passini, E, Zhou, X, Minchole, A, Britton, O, Bartolucci, C, Severi, S, Shrier, A, Virag, L, Varro, A, Rodriguez, B

“…These insights enable the reformulation of L-type calcium current, as well as replacement of the hERG current model.…”

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities by Trovato, C, Passini, E, Nagy, N, Varro, A, Abi-Gerges, N, Severi, S, Rodriguez, B

“…Simulations demonstrate the human Purkinje Trovato2020 model is the first one to yield: (i) all key AP features consistent with human Purkinje recordings; (ii) Automaticity with funny current up-regulation (iii) EADs at slow pacing and with 85% hERG block; (iv) DADs following fast pacing; (v) conduction velocity of 160 cm/s in a Purkinje fibre, as reported in human. …”

Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block by Paci, M, Hyttinen, J, Rodriguez, B, Severi, S

“…Their combination was recently proposed as a potential replacement for the present hERG-based QT study for pharmacological safety assessments. …”